DE60333004D1 - Antikrebsmittel mit verotoxinvarianten - Google Patents
Antikrebsmittel mit verotoxinvariantenInfo
- Publication number
- DE60333004D1 DE60333004D1 DE60333004T DE60333004T DE60333004D1 DE 60333004 D1 DE60333004 D1 DE 60333004D1 DE 60333004 T DE60333004 T DE 60333004T DE 60333004 T DE60333004 T DE 60333004T DE 60333004 D1 DE60333004 D1 DE 60333004D1
- Authority
- DE
- Germany
- Prior art keywords
- verotoxin
- subunit
- attenuated
- anticrope
- variants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010017898 Shiga Toxins Proteins 0.000 title abstract 6
- 230000002238 attenuated effect Effects 0.000 abstract 3
- 238000001415 gene therapy Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002026577 | 2002-02-04 | ||
| PCT/JP2003/001043 WO2003066854A1 (fr) | 2002-02-04 | 2003-02-03 | Agent anticancereux utilisant des variantes de verotoxines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60333004D1 true DE60333004D1 (de) | 2010-07-29 |
Family
ID=27677819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60333004T Expired - Lifetime DE60333004D1 (de) | 2002-02-04 | 2003-02-03 | Antikrebsmittel mit verotoxinvarianten |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20050163807A1 (de) |
| EP (1) | EP1496116B1 (de) |
| JP (1) | JP4214397B2 (de) |
| AT (1) | ATE471371T1 (de) |
| AU (1) | AU2003208097A1 (de) |
| DE (1) | DE60333004D1 (de) |
| WO (1) | WO2003066854A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070059382A1 (en) * | 2005-09-09 | 2007-03-15 | Board Of Regents, Univ. And Comm. College System Of Nevada... | Medical treatment of breast cancer with boric acid materials |
| EP2207793A2 (de) * | 2007-10-08 | 2010-07-21 | Rutgers, The State University | Nicht toxische shigatoxinmutanten-zusammensetzungen und entsprechende verfahren |
| ES2622840T3 (es) * | 2009-08-28 | 2017-07-07 | The Hospital For Sick Children | Uso de una holotoxina para reducir la degradación asociada al retículo endoplásmico de proteínas mal plegadas |
| CN104411608B (zh) | 2012-06-28 | 2016-09-21 | 环球仪器公司 | 一种装配机械、装配方法及用于装配印刷电路板的拾放机 |
| CA2902324A1 (en) * | 2013-03-12 | 2014-10-09 | Molecular Templates, Inc. | Cd20-binding immunotoxins for inducing cellular internalization and methods using same |
| IL287490B (en) | 2014-01-27 | 2022-08-01 | Molecular Templates Inc | Shiga toxin nonvaccine effector subunit-containing polypeptides for mammalian applications |
| US9955618B2 (en) | 2014-02-07 | 2018-04-24 | Universal Instruments Corporation | Pick and place head with internal vaccum and air pressure supply, system and method |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| JP6935195B2 (ja) * | 2014-03-11 | 2021-09-15 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質 |
| MX2016011821A (es) * | 2014-03-11 | 2017-04-27 | Molecular Templates Inc | Proteinas que comprenden regiones efectoras de subunidad a de toxina shiga proximas a amino terminal y regiones de union de tipo inmunoglobulina de direccionamiento selectivo celular. |
| CN113831416A (zh) | 2014-06-11 | 2021-12-24 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| ES2856457T3 (es) | 2015-02-05 | 2021-09-27 | Molecular Templates Inc | Moléculas de unión a CD20 multivalentes que comprenden regiones efectoras de una subunidad de toxina shiga y composiciones enriquecidas de estas |
| CA2984635A1 (en) | 2015-05-30 | 2016-12-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| EP3325510A2 (de) * | 2015-07-26 | 2018-05-30 | Molecular Templates, Inc. | Gegen zellen gerichtete moleküle mit effektoren der shigatoxin-a-untereinheit und cd8+-t-zellepitopen |
| WO2018106895A1 (en) | 2016-12-07 | 2018-06-14 | Molecular Templates, Inc. | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
| US10454114B2 (en) | 2016-12-22 | 2019-10-22 | The Research Foundation For The State University Of New York | Method of producing stable, active and mass-producible Pt3Ni catalysts through preferential co etching |
| AU2018213194B2 (en) | 2017-01-25 | 2023-01-12 | Molecular Templates, Inc. | Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes |
| AU2019257343A1 (en) | 2018-04-17 | 2020-09-10 | Molecular Templates, Inc. | HER2-targeting molecules comprising de-immunized, Shiga toxin A Subunit scaffolds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552144A (en) * | 1992-01-22 | 1996-09-03 | Microcarb, Inc. | Immunogenic shiga-like toxin II variant mutants |
| CA2116179C (en) | 1994-02-22 | 2008-01-08 | C. A. Lingwood | Verotoxin pharmaceutical compositions and medical treatments therewith |
| US5968894A (en) * | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
| US5837680A (en) * | 1996-02-16 | 1998-11-17 | Children's Medical Center Corporation | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
| WO1998051326A1 (en) * | 1997-05-16 | 1998-11-19 | Hsc Research And Development Limited Partnership | Inhibition of angiogenesis by verotoxins |
-
2003
- 2003-02-03 DE DE60333004T patent/DE60333004D1/de not_active Expired - Lifetime
- 2003-02-03 US US10/503,415 patent/US20050163807A1/en not_active Abandoned
- 2003-02-03 AU AU2003208097A patent/AU2003208097A1/en not_active Abandoned
- 2003-02-03 JP JP2003566204A patent/JP4214397B2/ja not_active Expired - Fee Related
- 2003-02-03 WO PCT/JP2003/001043 patent/WO2003066854A1/ja not_active Ceased
- 2003-02-03 AT AT03703141T patent/ATE471371T1/de not_active IP Right Cessation
- 2003-02-03 EP EP03703141A patent/EP1496116B1/de not_active Expired - Lifetime
-
2007
- 2007-03-02 US US11/681,395 patent/US20070154485A1/en not_active Abandoned
-
2009
- 2009-10-15 US US12/580,026 patent/US20100047285A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE471371T1 (de) | 2010-07-15 |
| EP1496116B1 (de) | 2010-06-16 |
| WO2003066854A1 (fr) | 2003-08-14 |
| AU2003208097A1 (en) | 2003-09-02 |
| HK1073130A1 (en) | 2005-09-23 |
| EP1496116A4 (de) | 2005-08-24 |
| US20100047285A1 (en) | 2010-02-25 |
| US20050163807A1 (en) | 2005-07-28 |
| EP1496116A1 (de) | 2005-01-12 |
| US20070154485A1 (en) | 2007-07-05 |
| JP4214397B2 (ja) | 2009-01-28 |
| JPWO2003066854A1 (ja) | 2005-06-02 |
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