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MX2017013975A - Formas solidas de quinasas que modulan un compuesto. - Google Patents

Formas solidas de quinasas que modulan un compuesto.

Info

Publication number
MX2017013975A
MX2017013975A MX2017013975A MX2017013975A MX2017013975A MX 2017013975 A MX2017013975 A MX 2017013975A MX 2017013975 A MX2017013975 A MX 2017013975A MX 2017013975 A MX2017013975 A MX 2017013975A MX 2017013975 A MX2017013975 A MX 2017013975A
Authority
MX
Mexico
Prior art keywords
solid forms
compound
compound modulating
modulating kinases
ylmethyl
Prior art date
Application number
MX2017013975A
Other languages
English (en)
Other versions
MX386963B (es
Inventor
N Ibrahim Prabha
Conrad Visor Gary
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56008880&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017013975(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MX2017013975A publication Critical patent/MX2017013975A/es
Publication of MX386963B publication Critical patent/MX386963B/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

Las formas sólidas del compuesto, sal HCI de [5-(5-cloro-1H-pirrol o[2,3-b]piridin-3-ilmetil)-piridin-2-il]-(6-trifluorometil-piridi n-3-ilmetil)amina (Compuesto I) y su base libre, activa en las proteínas quinasas del receptor de c-Kit y/o c-Fms y/o FIt3, se preparan y se caracterizan. También se proporcionan métodos para usar las formas sólidas.
MX2017013975A 2015-05-06 2016-05-05 Formas sólidas de quinasas que modulan un compuesto. MX386963B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
PCT/US2016/031027 WO2016179415A1 (en) 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases

Publications (2)

Publication Number Publication Date
MX2017013975A true MX2017013975A (es) 2018-01-16
MX386963B MX386963B (es) 2025-03-19

Family

ID=56008880

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013975A MX386963B (es) 2015-05-06 2016-05-05 Formas sólidas de quinasas que modulan un compuesto.

Country Status (29)

Country Link
US (4) US9802932B2 (es)
EP (2) EP3292123B1 (es)
JP (1) JP6946194B2 (es)
KR (1) KR102630889B1 (es)
CN (1) CN107548394B (es)
AU (1) AU2016258027B2 (es)
BR (1) BR112017023490B1 (es)
CA (1) CA2984910C (es)
CO (1) CO2017011534A2 (es)
CY (1) CY1123796T1 (es)
DK (1) DK3292123T3 (es)
ES (1) ES2820827T3 (es)
HR (1) HRP20201383T1 (es)
HU (1) HUE050506T2 (es)
IL (1) IL255313A0 (es)
LT (1) LT3292123T (es)
MX (1) MX386963B (es)
MY (1) MY192352A (es)
NZ (1) NZ737616A (es)
PH (1) PH12017501995A1 (es)
PT (1) PT3292123T (es)
RS (1) RS60731B1 (es)
RU (1) RU2730506C2 (es)
SG (1) SG10201912355TA (es)
SI (1) SI3292123T1 (es)
SM (1) SMT202000535T1 (es)
TW (1) TWI727949B (es)
WO (1) WO2016179415A1 (es)
ZA (1) ZA201708007B (es)

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