[go: up one dir, main page]

MX2017013875A - Ciertos inhibidores de la proteína quinasa. - Google Patents

Ciertos inhibidores de la proteína quinasa.

Info

Publication number
MX2017013875A
MX2017013875A MX2017013875A MX2017013875A MX2017013875A MX 2017013875 A MX2017013875 A MX 2017013875A MX 2017013875 A MX2017013875 A MX 2017013875A MX 2017013875 A MX2017013875 A MX 2017013875A MX 2017013875 A MX2017013875 A MX 2017013875A
Authority
MX
Mexico
Prior art keywords
certain inhibitors
quinasa
protein
protein quinasa
inhibitors
Prior art date
Application number
MX2017013875A
Other languages
English (en)
Other versions
MX395032B (es
Inventor
Weibo Wang
Yang Lijun
Li Tongshuang
Zhao Xingdong
Tan Haohan
Wang Xianlong
Liu Qihong
Jiang Lihua
Liu Yanxin
Lin Min
Sun Jing
Chen Zhifang
LINGHU Li
Chen Ling
Rong Yue
Tan Rui
Zhou Zuwen
Liu Bin
Original Assignee
Chongqing Fochon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57198165&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017013875(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chongqing Fochon Pharmaceutical Co Ltd filed Critical Chongqing Fochon Pharmaceutical Co Ltd
Publication of MX2017013875A publication Critical patent/MX2017013875A/es
Publication of MX395032B publication Critical patent/MX395032B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Se proporcionan aquí ciertos inhibidores de la CDK4/6, composiciones farmacéuticas de los mismos, y métodos para usarlos.
MX2017013875A 2015-04-28 2016-04-28 Ciertos inhibidores de la proteína quinasa. MX395032B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562154082P 2015-04-28 2015-04-28
PCT/CN2016/080475 WO2016173505A1 (en) 2015-04-28 2016-04-28 Certain protein kinase inhibitor

Publications (2)

Publication Number Publication Date
MX2017013875A true MX2017013875A (es) 2018-06-22
MX395032B MX395032B (es) 2025-03-24

Family

ID=57198165

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013875A MX395032B (es) 2015-04-28 2016-04-28 Ciertos inhibidores de la proteína quinasa.

Country Status (10)

Country Link
US (1) US10450316B2 (es)
EP (1) EP3288931B2 (es)
CN (1) CN107849012B (es)
BR (1) BR112017023225A2 (es)
DK (1) DK3288931T4 (es)
ES (1) ES2766498T5 (es)
MX (1) MX395032B (es)
RU (1) RU2732952C2 (es)
TW (1) TWI696617B (es)
WO (1) WO2016173505A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE042390T2 (hu) 2014-06-19 2019-06-28 Ariad Pharma Inc Heteroaril vegyületek kinázgátlásra
CN106608879A (zh) * 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
CA3047876C (en) 2016-12-22 2023-08-29 Betta Pharmaceuticals Co., Ltd Benzimidazole derivatives, preparation methods and uses thereof
CN108794452B (zh) 2017-05-05 2021-05-28 上海时莱生物技术有限公司 具有激酶抑制活性的化合物、其制备方法和用途
ES2923415T3 (es) 2017-08-11 2022-09-27 Shengke Pharmaceuticals Jiangsu Ltd Compuesto de 1H-pirazolo[4,3-H]quinazolina que sirve como inhibidor de proteína quinasa
TW201920141A (zh) 2017-08-15 2019-06-01 中國大陸商北京軒義醫藥科技有限公司 Cdk4/6抑制劑及其用途
EP3793993A4 (en) 2018-05-14 2022-01-05 Takeda Pharmaceutical Company Limited PHARMACEUTICAL SALT OF PYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF DISORDERS
CA3104365A1 (en) * 2018-06-21 2019-12-26 Betta Pharmaceuticals Co., Ltd Crystal form of compound for inhibiting the activity of cdk4/6 and use thereof
WO2022148354A1 (zh) * 2021-01-05 2022-07-14 山东轩竹医药科技有限公司 多环类激酶抑制剂
WO2022199656A1 (zh) * 2021-03-24 2022-09-29 贝达药业股份有限公司 药物组合、包含其的试剂盒及其用途
WO2025016439A1 (zh) * 2023-07-19 2025-01-23 浙江同源康医药股份有限公司 用作cdk2/4蛋白激酶抑制剂的化合物及其应用
CN118405996B (zh) * 2024-04-23 2025-09-09 仁合益康集团有限公司 一种依伏卡塞的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122016021801B8 (pt) 2002-01-22 2021-05-25 Warner Lambert Co compostos 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas
US8372851B2 (en) 2005-10-21 2013-02-12 Exelixis, Inc. Pyrazolo pyrimidines as casein kinase II (CK2) modulators
KR20080110912A (ko) 2006-04-19 2008-12-19 노파르티스 아게 인다졸 화합물 및 ｃｄｃ７의 억제 방법
CA2734802C (en) * 2008-08-22 2016-05-31 Novartis Ag Pyrrolopyrimidine compounds as cdk inhibitors
JO2885B1 (en) * 2008-12-22 2015-03-15 ايلي ليلي اند كومباني Protein kinase inhibitors
TW201035101A (en) * 2009-02-26 2010-10-01 Eisai R&D Man Co Ltd Nitrogen-containing fused heterocyclic compound
CN105189481A (zh) 2013-03-13 2015-12-23 艾伯维公司 吡啶cdk9激酶抑制剂
GB201321729D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321730D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321728D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP6263269B2 (ja) * 2013-12-31 2018-01-17 シュエンジュウ・ファーマ・カンパニー・リミテッド キナーゼ阻害剤及びその使用
CN104910137B (zh) * 2014-03-10 2017-04-19 山东轩竹医药科技有限公司 Cdk激酶抑制剂
EP3191469B1 (en) 2014-07-24 2021-12-15 Beta Pharma, Inc. 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof
UY36630A (es) 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
CN105153119B (zh) 2015-09-11 2019-01-01 广州必贝特医药技术有限公司 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用
CN106608879A (zh) † 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
RU2680777C1 (ru) * 2018-02-14 2019-02-26 Сергей Викторович Яблочко Направляющий аппарат центробежного многоступенчатого насоса

Also Published As

Publication number Publication date
EP3288931B1 (en) 2019-11-06
WO2016173505A1 (en) 2016-11-03
CN107849012A (zh) 2018-03-27
ES2766498T5 (es) 2022-11-18
RU2732952C2 (ru) 2020-09-24
MX395032B (es) 2025-03-24
CN107849012B (zh) 2021-05-25
TW201713645A (zh) 2017-04-16
BR112017023225A2 (pt) 2018-08-07
EP3288931A1 (en) 2018-03-07
TWI696617B (zh) 2020-06-21
EP3288931B2 (en) 2022-07-20
DK3288931T4 (da) 2022-10-24
RU2017141077A (ru) 2019-05-28
ES2766498T3 (es) 2020-06-12
EP3288931A4 (en) 2018-10-10
US20180291027A1 (en) 2018-10-11
RU2017141077A3 (es) 2019-08-14
US10450316B2 (en) 2019-10-22
DK3288931T3 (da) 2020-02-03

Similar Documents

Publication Publication Date Title
MX2017013875A (es) Ciertos inhibidores de la proteína quinasa.
MX2016015565A (es) Ciertos inhibidores de la proteina quinasa.
MX391501B (es) Agentes inductores de apoptosis
MX2018005528A (es) Inhibidores de ret.
CO2018005381A2 (es) Inhibidores éster de acc y usos de los mismos
CL2017003107A1 (es) Derivados de 2-(pirazolopiridin-3-il)pirimidina como inhibidores de jak
BR112019012343A2 (pt) anticorpos il-11ra
CO2017002532A2 (es) Indazoles sustituidos con bencilo como inhibidores de bub1
CY1120935T1 (el) Νεες συνθεσεις, χρησεις και μεθοδοι για την παρασκευη αυτων
EA201890749A1 (ru) ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ
ECSP17023281A (es) Inhibidores de mk2 y sus usos
MX2016013457A (es) Inhibidores de mdm2 y metodos terapeuticos que utilizan el mismo.
ECSP17030878A (es) Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidina-2,4-diamina
CY1124338T1 (el) Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτων
BR112017013568A2 (pt) compostos bicíclicos fundidos para o tratamento de doenças
CL2018001837A1 (es) Compuestos antiproliferativos y sus composiciones farmacéuticas y usos
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
MX2017013874A (es) Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
EA201791992A1 (ru) Ингибиторы грелин-o-ацилтрансферазы
EA201792000A1 (ru) Ингибиторы грелин-o-ацилтрансферазы
EA201890364A1 (ru) СОЕДИНЕНИЯ, ПРИГОДНЫЕ ДЛЯ ИНГИБИРОВАНИЯ ROR-ГАММА-t
UY36117A (es) Composiciones farmacéuticas para el tratamiento de enfermedades infecciosas.
MX2017014300A (es) Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos.
UY37551A (es) Activador de nrf2
MX2017003589A (es) Compuestos de indolinona y usos de los mismos.