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MX2017013325A - Dispositivo de sellado para hacer posible recolectar una composicion, conjunto de empaque que comprende tal dispositivo de sellado, metodos de recoleccion y empaque. - Google Patents

Dispositivo de sellado para hacer posible recolectar una composicion, conjunto de empaque que comprende tal dispositivo de sellado, metodos de recoleccion y empaque.

Info

Publication number
MX2017013325A
MX2017013325A MX2017013325A MX2017013325A MX2017013325A MX 2017013325 A MX2017013325 A MX 2017013325A MX 2017013325 A MX2017013325 A MX 2017013325A MX 2017013325 A MX2017013325 A MX 2017013325A MX 2017013325 A MX2017013325 A MX 2017013325A
Authority
MX
Mexico
Prior art keywords
sealing device
collection
collect
composition
making
Prior art date
Application number
MX2017013325A
Other languages
English (en)
Inventor
Marc DUBAELE Jean-
Guillemaut Thierry
Original Assignee
Centre Hospitalier Univ Damiens Picardie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Hospitalier Univ Damiens Picardie filed Critical Centre Hospitalier Univ Damiens Picardie
Publication of MX2017013325A publication Critical patent/MX2017013325A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1481—Inlet or outlet ports with connection retaining means, e.g. thread or snap-fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/12—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having removable closures
    • B65D47/14—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having removable closures and closure-retaining means

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La presente invención es concerniente con un dispositivo de sellado (1) para hacer posible recolectar una composición que es destinada para administración enteral o nasal o para uso tópico y está contenida en un recipiente. El dispositivo de sellado es caracterizado porque comprende: una punta (2) que define un paso interno (3) que conduce a una abertura (4) y es diseñada para permitir conexión a un elemento de recolección, tal como una jeringa enteral, una válvula anti-retorno (5) que es asociada con la punta (2) y es diseñada para abrirse durante la recolección del contenido del recipiente usando el elemento de recolección - por lo menos una compuerta de retorno de aire (6) y un filtro antibacteriano (7) asociado con la por lo menos una compuerta (6).
MX2017013325A 2015-04-17 2016-04-14 Dispositivo de sellado para hacer posible recolectar una composicion, conjunto de empaque que comprende tal dispositivo de sellado, metodos de recoleccion y empaque. MX2017013325A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1553442A FR3035080B1 (fr) 2015-04-17 2015-04-17 Dispositif de bouchage pour permettre un prelevement d'une composition ensemble de conditionnement comprenant un tel dispositif de bouchage, procedes de prelevement et de conditionnement
PCT/EP2016/058194 WO2016166197A1 (fr) 2015-04-17 2016-04-14 Dispositif de bouchage pour permettre un prélèvement d'une composition ensemble de conditionnement comprenant un tel dispositif de bouchage, procédés de prélèvement et de conditionnement

Publications (1)

Publication Number Publication Date
MX2017013325A true MX2017013325A (es) 2018-06-22

Family

ID=53758358

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013325A MX2017013325A (es) 2015-04-17 2016-04-14 Dispositivo de sellado para hacer posible recolectar una composicion, conjunto de empaque que comprende tal dispositivo de sellado, metodos de recoleccion y empaque.

Country Status (15)

Country Link
US (1) US11090226B2 (es)
EP (1) EP3283043B1 (es)
JP (2) JP2018512990A (es)
KR (1) KR20180008501A (es)
CN (1) CN107750225B (es)
CA (1) CA2982935A1 (es)
ES (1) ES2745278T3 (es)
FR (1) FR3035080B1 (es)
HK (1) HK1249006A1 (es)
IL (1) IL255082A0 (es)
MX (1) MX2017013325A (es)
PL (1) PL3283043T3 (es)
PT (1) PT3283043T (es)
RU (1) RU2710242C2 (es)
WO (1) WO2016166197A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10709850B2 (en) 2018-06-15 2020-07-14 James T. Doubet Syringe adapter for medication
ES1173259Y (es) * 2016-12-15 2017-03-22 Inst De Tecnologia Y Estetica Pharma S L Kit de utilizacion in situ para garantizar la calidad de un producto cosmetico aplicable a seres vivos
IT201700032091A1 (it) * 2017-03-23 2018-09-23 Bormioli Pharma S R L Riduttore per siringa
FR3080368B1 (fr) 2018-04-20 2021-04-23 Virbac Dispositif de protection contre les chocs apte a equiper une bouteille
CN108685688B (zh) * 2018-06-12 2024-05-17 张家港众辉医用塑料科技有限公司 三级过滤无菌药液包装
US20190388625A1 (en) * 2018-06-15 2019-12-26 James T. Doubet Syringe adapter for medication
US11103641B1 (en) 2020-04-26 2021-08-31 Paul D. Doubet Container adapter for removably attachable syringe
FR3162142A1 (fr) 2024-05-15 2025-11-21 Macadamia Dispositif de bouchage anticontamination multidose

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB918161A (en) * 1961-08-05 1963-02-13 Millipore Filter Corp Fluid sampling device
US3654926A (en) * 1969-11-17 1972-04-11 Parke Davis & Co Mixing vial
US4230112A (en) * 1978-08-07 1980-10-28 Smith Philip E Syringe-type liquid container dispenser adapter
US4493348A (en) * 1981-06-29 1985-01-15 Pur/Acc Corporation Method and apparatus for orally dispensing liquid medication
US4743243A (en) * 1984-01-03 1988-05-10 Vaillancourt Vincent L Needle with vent filter assembly
IE57676B1 (en) 1984-03-19 1993-02-24 Abbott Lab Drug delivery system
US4834152A (en) 1986-02-27 1989-05-30 Intelligent Medicine, Inc. Storage receptacle sealing and transfer apparatus
USRE37243E1 (en) * 1993-03-24 2001-06-26 Portola Packaging, Inc. Neck finish for a container and a matching registering multiple thread pattern in a flexible cap for engagement on said neck finish
US5702019A (en) * 1995-09-27 1997-12-30 Becton Dickinson France S.A. Vial having resealable membrane assembly activated by a medical delivery device
US5924584A (en) 1997-02-28 1999-07-20 Abbott Laboratories Container closure with a frangible seal and a connector for a fluid transfer device
CA2262477C (en) 1998-05-16 2008-02-12 Bracco International B.V. Multiple use universal stopper
US6139534A (en) * 2000-01-24 2000-10-31 Bracco Diagnostics, Inc. Vial access adapter
SE517084C2 (sv) * 2000-08-10 2002-04-09 Carmel Pharma Ab Förfarande och anordningar vid aseptisk beredning
GB0226347D0 (en) 2002-11-12 2002-12-18 Boots Healthcare Int Ltd Improvements in and relating to liquid dispensing
FR2870827B3 (fr) 2004-06-01 2006-04-28 Pharmaglass Sarl Ensemble de conditionnement et de disribution d'un produit, en particulier pharmaceutique, par doses prelevees a la seringue, et insetr de distribution correspondant.
FR2872137B1 (fr) * 2004-06-24 2009-01-23 Thea Sa Lab Recipient pour le conditionnement d'un liquide a distributeur goutte a goutte, a deformation reversible par admission d'air
US7731678B2 (en) * 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US8167863B2 (en) * 2006-10-16 2012-05-01 Carefusion 303, Inc. Vented vial adapter with filter for aerosol retention
FR2928539B1 (fr) 2008-03-12 2012-02-24 Vygon Dispositif d'interfacage pour flacons a perforer a fins de preparations de liquides perfuses
US8034044B2 (en) * 2008-04-04 2011-10-11 B. Braun Melsungen Ag Systems and methods for combining materials
FR2930725B1 (fr) * 2008-04-30 2010-08-13 Oreal Compositions a base de complexes polymere-peroxyde d'hydrogene et leurs utilisations
WO2013116670A1 (en) * 2012-02-01 2013-08-08 Hospi Corporation Valved enteral administration assembly
RU85332U1 (ru) * 2009-03-03 2009-08-10 Сергей Анатольевич Бабичев Заборник пробы содержимого зубодесневого кармана и/или зубодесневой борозды для микробиологического исследования
DE102009040016B4 (de) * 2009-09-04 2016-02-25 Jan Willem Marinus Mijers Vorrichtung zur Applikation von fluidalen Medikamenten
US8651305B1 (en) * 2009-09-30 2014-02-18 Simplified Dosing Incorporated Reclosable container closure
US9296531B2 (en) * 2010-01-12 2016-03-29 Medela Holding Ag Container with sealed cap and venting system
JP2011212361A (ja) 2010-04-01 2011-10-27 Terumo Corp 薬剤投与具
WO2012017547A1 (ja) * 2010-08-06 2012-02-09 イーエヌ大塚製薬株式会社 逆止弁、三方活栓ユニット、流動性物質移送具
JP2013540564A (ja) * 2010-10-25 2013-11-07 ユニバーシティ・オブ・カンザス 薬剤容器の汚染防止用薬剤接触器材
JP6126530B2 (ja) * 2010-11-01 2017-05-10 ジーイー・ヘルスケア・リミテッド 無菌分注器
SG192312A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
FR2993174B1 (fr) 2012-07-16 2014-07-25 Rovipharm Dispositif apte a securiser la distribution d'un liquide contenu dans un flacon

Also Published As

Publication number Publication date
JP2021184862A (ja) 2021-12-09
US11090226B2 (en) 2021-08-17
RU2017136441A3 (es) 2019-07-29
HK1246256A1 (zh) 2018-09-07
CN107750225A (zh) 2018-03-02
EP3283043A1 (fr) 2018-02-21
FR3035080A1 (fr) 2016-10-21
IL255082A0 (en) 2017-12-31
ES2745278T3 (es) 2020-02-28
FR3035080B1 (fr) 2019-08-09
US20180104150A1 (en) 2018-04-19
RU2017136441A (ru) 2019-05-17
EP3283043B1 (fr) 2019-06-12
JP2018512990A (ja) 2018-05-24
HK1249006A1 (zh) 2018-10-26
WO2016166197A1 (fr) 2016-10-20
KR20180008501A (ko) 2018-01-24
PL3283043T3 (pl) 2020-03-31
CN107750225B (zh) 2019-10-11
CA2982935A1 (fr) 2016-10-20
PT3283043T (pt) 2019-09-26
RU2710242C2 (ru) 2019-12-25

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