|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
GB8705477D0
(en)
|
1987-03-09 |
1987-04-15 |
Carlton Med Prod |
Drug delivery systems
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
WO1990003430A1
(en)
|
1988-09-23 |
1990-04-05 |
Cetus Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
DE122004000008I1
(de)
|
1991-06-14 |
2005-06-09 |
Genentech Inc |
Humanisierter Heregulin Antikörper.
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
DE69315847T2
(de)
|
1992-08-21 |
1998-06-25 |
Genentech Inc |
Verfahren zur behandlung einer durch lfa-1 vermittelten störung
|
|
PL174494B1
(pl)
|
1992-11-13 |
1998-08-31 |
Idec Pharma Corp |
Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B
|
|
ATE216590T1
(de)
|
1995-02-06 |
2002-05-15 |
Genetics Inst |
Arzneimittelformulierungen für il-12
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
US6060284A
(en)
|
1997-07-25 |
2000-05-09 |
Schering Corporation |
DNA encoding interleukin-B30
|
|
CO4810232A1
(es)
|
1997-07-25 |
1999-06-30 |
Schering Corp |
Citoquinas de mamiferos y sus secuencias codificadoras
|
|
AU2661199A
(en)
|
1998-02-06 |
1999-08-23 |
Schering Corporation |
Mammalian receptor proteins; related reagents and methods
|
|
WO1999054357A1
(en)
|
1998-04-14 |
1999-10-28 |
Chugai Research Institute For Molecular Medicine, Inc. |
Novel cytokine-like protein
|
|
US6367172B2
(en)
|
1999-07-02 |
2002-04-09 |
Bbc International Ltd. |
Flex sole
|
|
US7090847B1
(en)
|
1999-09-09 |
2006-08-15 |
Schering Corporation |
Mammalian cytokines; related reagents and methods
|
|
US7422743B2
(en)
|
2000-05-10 |
2008-09-09 |
Schering Corporation |
Mammalian receptor protein DCRS5;methods of treatment
|
|
PL209128B1
(pl)
|
2000-05-10 |
2011-07-29 |
Schering Corp |
Białko receptora spokrewnionego z receptorami cytokin oraz związane z nim produkty, sposoby i zastosowania
|
|
JPWO2003034818A1
(ja)
|
2001-10-24 |
2005-02-10 |
中外製薬株式会社 |
Sgrf遺伝子改変非ヒト動物
|
|
CN1292655C
(zh)
|
2001-11-08 |
2007-01-03 |
蛋白质设计实验室股份有限公司 |
IgG抗体稳定的液态药物制剂
|
|
MXPA05004512A
(es)
|
2002-10-30 |
2005-07-26 |
Genentech Inc |
Inhibicion de la produccion de il-17.
|
|
ATE515514T1
(de)
|
2002-12-23 |
2011-07-15 |
Schering Corp |
Verwendungen von säuger-cytokin il-23 ; verwandte reagenzien
|
|
WO2004071517A2
(en)
|
2003-02-06 |
2004-08-26 |
Schering Corporation |
Uses of il-23 related reagents
|
|
BRPI0408247A
(pt)
|
2003-03-10 |
2006-03-01 |
Schering Corp |
usos de antagonistas e agonistas de il-23 e reagentes relacionados
|
|
WO2005005612A2
(en)
|
2003-07-01 |
2005-01-20 |
University Of Virginia Patent Foundation |
Tag-1 and tag-2 proteins and uses thereof
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
ATE474599T1
(de)
|
2003-11-04 |
2010-08-15 |
Novartis Vaccines & Diagnostic |
Verwendung von antagonisten-anti-cd40- monoklonalen antikörpern zur behandlung von multiplem myelom
|
|
EP2149585B1
(en)
|
2003-11-04 |
2013-08-14 |
Novartis Vaccines and Diagnostics, Inc. |
Use of antagonistic anti-CD40 monoclonal antibodies
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
WO2005079837A1
(en)
|
2004-02-17 |
2005-09-01 |
Schering Corporation |
Methods of modulating il-23 activity; related reagents
|
|
US20050287593A1
(en)
|
2004-05-03 |
2005-12-29 |
Schering Corporation |
Use of cytokine expression to predict skin inflammation; methods of treatment
|
|
JP2007535930A
(ja)
|
2004-05-03 |
2007-12-13 |
シェーリング コーポレイション |
皮膚の炎症を予測するためのil−17発現の使用;処置方法
|
|
US20060084145A1
(en)
|
2004-09-27 |
2006-04-20 |
Anderson Glenn M |
sRAGE mimetibody, compositions, methods and uses
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
TWI363091B
(en)
|
2004-12-20 |
2012-05-01 |
Schering Corp |
Uses of mammalian cytokine; related reagents
|
|
AU2006265898A1
(en)
|
2005-06-30 |
2007-01-11 |
Archemix Corp. |
Polynucleotides and polypeptides of the IL-12 family of cytokines
|
|
US7491391B2
(en)
|
2005-06-30 |
2009-02-17 |
Centocor, Inc. |
Anti-IL-23 antibodies, compositions, methods and uses
|
|
PT1937721E
(pt)
|
2005-08-25 |
2010-09-17 |
Lilly Co Eli |
Anticorpos anti-il-23
|
|
HUE032131T2
(en)
|
2005-08-31 |
2017-09-28 |
Merck Sharp & Dohme |
Constructed anti-IL-23 antibodies
|
|
DE602006009834D1
(de)
|
2005-09-01 |
2009-11-26 |
Schering Corp |
Verwendung von il-23 und il-17-antagonisten zur behandlung von autoimmuner entzündlicher augenerkrankung
|
|
EP1977007A4
(en)
|
2005-12-28 |
2009-11-11 |
Centocor Ortho Biotech Inc |
MARKERS AND METHOD FOR THE ASSESSMENT AND TREATMENT OF PSORIASIS AND RELATED DISEASES
|
|
CN101389351B
(zh)
|
2005-12-29 |
2012-10-10 |
森托科尔公司 |
人抗il-23抗体、组合物、方法和用途
|
|
US7910703B2
(en)
|
2006-03-10 |
2011-03-22 |
Zymogenetics, Inc. |
Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
|
|
US20080311043A1
(en)
|
2006-06-08 |
2008-12-18 |
Hoffman Rebecca S |
Uses and compositions for treatment of psoriatic arthritis
|
|
CA2655372A1
(en)
|
2006-06-13 |
2007-12-21 |
Zymogenetics, Inc. |
Il-17 and il-23 antagonists and methods of using the same
|
|
AU2007261019A1
(en)
|
2006-06-19 |
2007-12-27 |
Wyeth |
Methods of modulating IL-22 and IL-17
|
|
CL2008000058A1
(es)
|
2007-01-09 |
2008-05-23 |
Wyeth Corp |
Formulacion que comprende un anticuerpo anti-il13, un criprotector, y una solucion amortiguadora; composicion farmaceutica que la comprende; metodo para tratar un trastorno relacionado con il13; y formas farmaceuticas que la comprenden.
|
|
TWI426918B
(zh)
|
2007-02-12 |
2014-02-21 |
Merck Sharp & Dohme |
Il-23拮抗劑於治療感染之用途
|
|
US20080200591A1
(en)
|
2007-02-15 |
2008-08-21 |
Isao Noda |
Melt Processable Reactive Pellets Capable of Forming Ester Condensates and Process for Forming Melt Processable Reactive Pellets
|
|
KR20090110349A
(ko)
|
2007-02-16 |
2009-10-21 |
와이어쓰 |
소르비톨을 함유하는 단백질 제제
|
|
CN101663320A
(zh)
|
2007-02-23 |
2010-03-03 |
先灵公司 |
工程改造的抗IL-23p19抗体
|
|
DK2426144T3
(en)
|
2007-02-23 |
2019-01-07 |
Merck Sharp & Dohme |
Manipulated Anti-IL-23P19 Antibodies
|
|
US20100135998A1
(en)
|
2007-02-28 |
2010-06-03 |
Schering Corporation |
Combination therapy for treatment of immune disorders
|
|
SI2197903T1
(sl)
|
2007-09-04 |
2015-02-27 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer 6011 |
Izbris v obmoäśju ii pseudomonas eksotoksina a, ki zniĺ˝uje ne-specifiäśno toksiäśnost
|
|
AR068723A1
(es)
|
2007-10-05 |
2009-12-02 |
Glaxo Group Ltd |
Proteina que se une a antigenos que se une a il-23 humana y sus usos
|
|
EP2212442A1
(en)
|
2007-10-26 |
2010-08-04 |
Galderma Research & Development |
Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof
|
|
CA2607771A1
(en)
|
2007-11-01 |
2009-05-01 |
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence |
Humanized anti-venezuelan equine encephalitis virus recombinant antibody
|
|
CA2707483A1
(en)
|
2007-11-30 |
2009-06-11 |
Wolfgang Fraunhofer |
Protein formulations and methods of making same
|
|
WO2009082624A2
(en)
|
2007-12-10 |
2009-07-02 |
Zymogenetics, Inc. |
Antagonists of il-17a, il-17f, and il-23 and methods of using the same
|
|
MY153074A
(en)
|
2008-08-14 |
2014-12-31 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-il-12/11-23 antibodies
|
|
AU2009288419B2
(en)
|
2008-08-27 |
2015-08-06 |
Merck Sharp & Dohme Llc |
Lyophilized formulatons of engineered anti-IL-23p19 antibodies
|
|
WO2010062663A1
(en)
|
2008-11-03 |
2010-06-03 |
Schering Corporation |
Inflammatory bowel disease biomarkers and related methods of treatment
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
KR20110096553A
(ko)
|
2008-11-28 |
2011-08-30 |
아보트 러보러터리즈 |
안정한 항체 조성물 및 이의 안정화 방법
|
|
CA2757237A1
(en)
|
2009-04-01 |
2010-10-14 |
Jane Elizabeth Clarkson |
Anti-il-23 immunoglobulins
|
|
EP2414546A4
(en)
|
2009-04-02 |
2013-03-13 |
Univ Johns Hopkins |
COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASE AND COLON CARCINOMA
|
|
US20120269765A1
(en)
|
2009-07-24 |
2012-10-25 |
Garcia K Christopher |
Cytokine compositions and methods of use thereof
|
|
JO3244B1
(ar)
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
JP5934652B2
(ja)
|
2009-11-24 |
2016-06-15 |
アルダーバイオ ホールディングス エルエルシー |
Il−6に対する抗体およびその使用
|
|
CN102695465A
(zh)
|
2009-12-02 |
2012-09-26 |
斯帕泰克医疗股份有限公司 |
结合具有可偏转柱和复合脊柱杆的骨锚固件的小轮廓脊柱假体
|
|
GB201013975D0
(en)
|
2010-08-20 |
2010-10-06 |
Imp Innovations Ltd |
Method of treating desease
|
|
WO2011103105A1
(en)
|
2010-02-18 |
2011-08-25 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind il-23
|
|
CN107496917B
(zh)
|
2010-02-26 |
2021-06-11 |
诺沃—诺迪斯克有限公司 |
包含稳定抗体的组合物
|
|
CN102946861B
(zh)
|
2010-03-01 |
2016-01-20 |
西托戴恩有限公司 |
浓缩蛋白制剂及其用途
|
|
CA2798742A1
(en)
|
2010-06-15 |
2011-12-22 |
Celgene Corporation |
Biomarkers for the treatment of psoriasis
|
|
US20110311527A1
(en)
|
2010-06-16 |
2011-12-22 |
Allergan, Inc. |
IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS
|
|
AU2011282476B2
(en)
|
2010-07-20 |
2015-08-20 |
Cephalon Australia Pty Ltd |
Anti-IL-23 heterodimer specific antibodies
|
|
WO2012032181A2
(en)
|
2010-09-10 |
2012-03-15 |
Allozyne, Inc |
Novel antibody derivatives
|
|
MX2019000046A
(es)
|
2010-11-04 |
2023-10-05 |
Boehringer Ingelheim Int |
Anticuerpos anti-il-23.
|
|
GB201100282D0
(en)
|
2011-01-07 |
2011-02-23 |
Ucb Pharma Sa |
Biological methods
|
|
TW201309330A
(zh)
|
2011-01-28 |
2013-03-01 |
Abbott Lab |
包含糖基化抗體之組合物及其用途
|
|
WO2012104402A1
(en)
|
2011-02-04 |
2012-08-09 |
Ab Science |
Treatment of severe persitent asthma with masitinib
|
|
CN104507497B
(zh)
|
2012-05-03 |
2018-10-19 |
勃林格殷格翰国际有限公司 |
抗IL-23p19抗体
|
|
WO2013186230A1
(en)
|
2012-06-12 |
2013-12-19 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical formulation for a therapeutic antibody
|
|
WO2014004436A2
(en)
*
|
2012-06-27 |
2014-01-03 |
Merck Sharp & Dohme Corp. |
Crystalline anti-human il-23 antibodies
|
|
EA201591579A1
(ru)
|
2013-03-15 |
2016-01-29 |
Амген Инк. |
Способы лечения болезни крона при помощи анти-il-23 антитела
|
|
EP2968488A1
(en)
*
|
2013-03-15 |
2016-01-20 |
Amgen Inc. |
Methods for treating psoriasis using an anti-il-23 antibody
|
|
KR20140119396A
(ko)
|
2013-03-29 |
2014-10-10 |
삼성전자주식회사 |
단백질 약물의 액상 제형
|
|
WO2016014775A1
(en)
|
2014-07-24 |
2016-01-28 |
Boehringer Ingelheim International Gmbh |
Biomarkers useful in the treatment of il-23a related diseases
|
|
PH12017500370B1
(en)
|
2014-09-03 |
2023-12-06 |
Boehringer Ingelheim Int |
Compound targeting il-23a and tnf-alpha and uses thereof
|
|
IL307578A
(en)
|
2015-02-04 |
2023-12-01 |
Boehringer Ingelheim Int |
Methods of treating inflammatory diseases
|
|
KR20170135972A
(ko)
|
2015-04-14 |
2017-12-08 |
베링거 인겔하임 인터내셔날 게엠베하 |
질환을 치료하는 방법
|
|
EA201890360A1
(ru)
|
2015-07-23 |
2018-06-29 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Соединение, нацеленное на ил-23a и фактор активации в-лимфоцитов (baff), и его применение
|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ja)
*
|
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|
|
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|
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|
|
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|
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|