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MX2017008670A - Moleculas artificiales de acido nucleico novedosas. - Google Patents

Moleculas artificiales de acido nucleico novedosas.

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Publication number
MX2017008670A
MX2017008670A MX2017008670A MX2017008670A MX2017008670A MX 2017008670 A MX2017008670 A MX 2017008670A MX 2017008670 A MX2017008670 A MX 2017008670A MX 2017008670 A MX2017008670 A MX 2017008670A MX 2017008670 A MX2017008670 A MX 2017008670A
Authority
MX
Mexico
Prior art keywords
nucleic acid
artificial nucleic
utr
utr element
acid molecule
Prior art date
Application number
MX2017008670A
Other languages
English (en)
Inventor
Schlake Thomas
GRUND Stefanie
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of MX2017008670A publication Critical patent/MX2017008670A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

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Abstract

La invención se refiere a una molécula artificial de ácido nucleico que comprende al menos un marco de lectura abierto y al menos un elemento de región no traducido 3´ (elemento 3´-UTR) y/o al menos un elemento de región no traducido 5´ (elemento 5´-UTR), en donde al menos un elemento 3´-UTR y/o al menos un elemento 5´-UTR prolonga y/o incrementa la producción de proteína de la molécula artificial de ácido nucleico y en donde al menos un elemento 3´-UTR y/o al menos un elemento 5´-UTR se deriva de un mARN estable. La invención además se refiere al uso de tal molécula artificial de ácido nucleico en la terapia génica y/o vacunación genética. Además, se describen métodos para identificar un elemento 3´- UTR y/o un 5´-UTR derivado de un elemento de mARN estable.
MX2017008670A 2014-12-30 2015-12-29 Moleculas artificiales de acido nucleico novedosas. MX2017008670A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2014003479 2014-12-30
PCT/EP2015/081366 WO2016107877A1 (en) 2014-12-30 2015-12-29 Artificial nucleic acid molecules

Publications (1)

Publication Number Publication Date
MX2017008670A true MX2017008670A (es) 2017-10-11

Family

ID=52814040

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008670A MX2017008670A (es) 2014-12-30 2015-12-29 Moleculas artificiales de acido nucleico novedosas.

Country Status (12)

Country Link
US (3) US20180148727A1 (es)
EP (2) EP3240558A1 (es)
JP (2) JP6907116B2 (es)
KR (1) KR102580696B1 (es)
CN (1) CN107124889A (es)
AU (1) AU2015373404B2 (es)
BR (1) BR112017009835A2 (es)
CA (1) CA2966092A1 (es)
MX (1) MX2017008670A (es)
RU (1) RU2757675C2 (es)
SG (2) SG11201704681QA (es)
WO (1) WO2016107877A1 (es)

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