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MX2023006229A - Sistemas y metodos para identificar y expresar agrupaciones de genes. - Google Patents

Sistemas y metodos para identificar y expresar agrupaciones de genes.

Info

Publication number
MX2023006229A
MX2023006229A MX2023006229A MX2023006229A MX2023006229A MX 2023006229 A MX2023006229 A MX 2023006229A MX 2023006229 A MX2023006229 A MX 2023006229A MX 2023006229 A MX2023006229 A MX 2023006229A MX 2023006229 A MX2023006229 A MX 2023006229A
Authority
MX
Mexico
Prior art keywords
methods
gene clusters
identifying
systems
expressing gene
Prior art date
Application number
MX2023006229A
Other languages
English (en)
Inventor
Brian Thomas Naughton
Colin Harvey
Ulrich Schlecht
Maureen Elizabeth Hillenmeyer
Joe Horecka
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/469,452 external-priority patent/US10612032B2/en
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of MX2023006229A publication Critical patent/MX2023006229A/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen métodos para identificar agrupamientos de genes biosintéticos que incluyen genes para producir compuestos que interactúan con proteínas objetivo específicas. Algunos métodos se refieren a métodos bioinformáticos para identificar y/o priorizar agrupamiento de genes biosintéticos. También se describen sistemas relacionados, componentes, y herramientas para identificación y expresión de esos agrupamientos de genes.
MX2023006229A 2016-11-16 2019-05-15 Sistemas y metodos para identificar y expresar agrupaciones de genes. MX2023006229A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423196P 2016-11-16 2016-11-16
US15/469,452 US10612032B2 (en) 2016-03-24 2017-03-24 Inducible production-phase promoters for coordinated heterologous expression in yeast
US201762481601P 2017-04-04 2017-04-04

Publications (1)

Publication Number Publication Date
MX2023006229A true MX2023006229A (es) 2023-06-15

Family

ID=62145753

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019005701A MX2019005701A (es) 2016-11-16 2017-11-16 Sistemas y metodos para identificar y expresar agrupaciones de genes.
MX2023006229A MX2023006229A (es) 2016-11-16 2019-05-15 Sistemas y metodos para identificar y expresar agrupaciones de genes.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019005701A MX2019005701A (es) 2016-11-16 2017-11-16 Sistemas y metodos para identificar y expresar agrupaciones de genes.

Country Status (7)

Country Link
US (4) US20200040347A1 (es)
EP (2) EP3541936B1 (es)
CN (2) CN110268057B (es)
AU (1) AU2017363141B2 (es)
CA (1) CA3042726A1 (es)
MX (2) MX2019005701A (es)
WO (1) WO2018094110A2 (es)

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US10612032B2 (en) 2016-03-24 2020-04-07 The Board Of Trustees Of The Leland Stanford Junior University Inducible production-phase promoters for coordinated heterologous expression in yeast
CA3042726A1 (en) 2016-11-16 2018-05-24 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for identifying and expressing gene clusters
EP3652192A4 (en) * 2017-07-13 2021-10-06 Radici Chimica S.p.A. BIOLOGICAL PROCESSES FOR THE PREPARATION OF TERPENES
EP3682022A4 (en) 2017-09-14 2021-06-09 Lifemine Therapeutics, Inc. HUMAN THERAPEUTIC TARGET MOLECULES AND MODULATORS THEREOF
US11680256B2 (en) 2018-08-31 2023-06-20 Agency For Science, Technology And Research Methods for terpenoid production
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CN113053461B (zh) * 2021-03-15 2022-05-10 浙江大学 一种基于靶标的基因簇定向挖掘方法
CN113764034B (zh) * 2021-08-03 2023-09-22 腾讯科技（深圳）有限公司 基因组序列中潜在bgc的预测方法、装置、设备及介质
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WO2025101762A1 (en) * 2023-11-08 2025-05-15 Hexagon Bio, Inc. Methods for identification of compound interaction partners and compounds produced by gene clusters
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Also Published As

Publication number Publication date
AU2017363141A1 (en) 2019-05-23
US12456540B2 (en) 2025-10-28
US20240120023A1 (en) 2024-04-11
EP4556563A2 (en) 2025-05-21
US20230215512A1 (en) 2023-07-06
US20210230611A1 (en) 2021-07-29
EP3541936B1 (en) 2025-02-19
US20200040347A1 (en) 2020-02-06
CN118064425A (zh) 2024-05-24
WO2018094110A3 (en) 2018-08-09
AU2017363141B2 (en) 2024-06-27
EP3541936A4 (en) 2020-05-20
EP3541936C0 (en) 2025-02-19
EP4556563A3 (en) 2025-08-27
CN110268057B (zh) 2024-03-29
CN110268057A (zh) 2019-09-20
CA3042726A1 (en) 2018-05-24
EP3541936A2 (en) 2019-09-25
MX2019005701A (es) 2019-10-07
WO2018094110A2 (en) 2018-05-24

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