MX2016012314A - Analagos de apelina ciclicos. - Google Patents
Analagos de apelina ciclicos.Info
- Publication number
- MX2016012314A MX2016012314A MX2016012314A MX2016012314A MX2016012314A MX 2016012314 A MX2016012314 A MX 2016012314A MX 2016012314 A MX2016012314 A MX 2016012314A MX 2016012314 A MX2016012314 A MX 2016012314A MX 2016012314 A MX2016012314 A MX 2016012314A
- Authority
- MX
- Mexico
- Prior art keywords
- ala
- bridge
- cyclic apelin
- cyclic
- lantionin
- Prior art date
Links
- -1 Cyclic apelin analogs Chemical class 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Marine Sciences & Fisheries (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Control Of Stepping Motors (AREA)
Abstract
La invención se refiere al campo de la farmacología. En particular, se refiere a nuevos análogos de apelina, y a los usos terapéuticos de los mismos. Se proporciona un análogo de apelina cíclico de la fórmula general X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X 12-X13-X14, que comprende un puente de lantionina de la estructura Ala-S-Ala o un puente de metil-lantionina de la estructura Abu-S-Ala o Ala-S-Abu, y en donde dicho puente de (metil) lantionina es del tamaño i, i+3; i, i+4, i, i+5 o i, i+6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161533 | 2014-03-25 | ||
| PCT/NL2015/050191 WO2015147641A1 (en) | 2014-03-25 | 2015-03-25 | Cyclic apelin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016012314A true MX2016012314A (es) | 2016-11-30 |
| MX378539B MX378539B (es) | 2025-03-10 |
Family
ID=50389830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016012314A MX378539B (es) | 2014-03-25 | 2015-03-25 | Analagos de apelina ciclicos. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20170107257A1 (es) |
| EP (1) | EP3122764B1 (es) |
| JP (1) | JP6740133B2 (es) |
| KR (1) | KR20160135742A (es) |
| CN (1) | CN106170492B (es) |
| AU (1) | AU2015237357B2 (es) |
| BR (1) | BR112016021835A8 (es) |
| CA (1) | CA2941080A1 (es) |
| DK (1) | DK3122764T3 (es) |
| ES (1) | ES2719137T3 (es) |
| HR (1) | HRP20190544T1 (es) |
| HU (1) | HUE042615T2 (es) |
| IL (1) | IL246487A0 (es) |
| MX (1) | MX378539B (es) |
| PL (1) | PL3122764T3 (es) |
| PT (1) | PT3122764T (es) |
| RU (1) | RU2697515C2 (es) |
| SG (2) | SG10201808383UA (es) |
| WO (1) | WO2015147641A1 (es) |
| ZA (1) | ZA201607177B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106366168B (zh) * | 2016-08-26 | 2020-09-15 | 上海交通大学 | 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法 |
| GB202016149D0 (en) * | 2020-10-12 | 2020-11-25 | Heptares Therapeutics Ltd | Cyclic apelin receptor agonists |
| CN112851788B (zh) * | 2021-02-03 | 2022-11-01 | 河北省科学院生物研究所 | 一种羊毛硫肽LichencinA3及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19745583A1 (de) * | 1997-10-15 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben |
| US7101701B2 (en) * | 2004-10-08 | 2006-09-05 | The Trustees Of The University Of Pennsylvania | Method to reduce contamination when culturing mycobacteria |
| ATE512158T1 (de) * | 2005-08-12 | 2011-06-15 | Oragenics Inc | Differenziell geschützte, orthogonale lanthionintechnologie |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| US20090233854A1 (en) * | 2005-12-20 | 2009-09-17 | Takeda Pharmaceutical Company Limited | Novel application of apelin |
| CA2695487A1 (en) * | 2007-08-03 | 2009-02-12 | Sentinella Pharmaceuticals, Inc. ("Sentinella") | Genes and proteins for the biosynthesis of the lantibiotic 107891 |
| EP2405008A1 (en) * | 2010-07-06 | 2012-01-11 | LanthioPep B.V. | Bacterial surface display of thioether-bridge-containing peptides |
| EP2603586B2 (en) * | 2010-08-13 | 2025-02-26 | Miti Biosystems GmbH | Modified peptide display |
| DK2683360T3 (en) | 2011-03-11 | 2016-05-30 | Genzyme Corp | PEGYLED APELIN AND APPLICATIONS THEREOF |
| CN103483433B (zh) * | 2013-09-10 | 2015-05-27 | 中国科学院微生物研究所 | 一种新型高效的羊毛硫细菌素cerecidin及其应用 |
-
2015
- 2015-03-25 PL PL15720489T patent/PL3122764T3/pl unknown
- 2015-03-25 SG SG10201808383UA patent/SG10201808383UA/en unknown
- 2015-03-25 AU AU2015237357A patent/AU2015237357B2/en not_active Ceased
- 2015-03-25 RU RU2016139223A patent/RU2697515C2/ru not_active IP Right Cessation
- 2015-03-25 US US15/128,160 patent/US20170107257A1/en not_active Abandoned
- 2015-03-25 ES ES15720489T patent/ES2719137T3/es active Active
- 2015-03-25 HR HRP20190544TT patent/HRP20190544T1/hr unknown
- 2015-03-25 HU HUE15720489A patent/HUE042615T2/hu unknown
- 2015-03-25 SG SG11201605195RA patent/SG11201605195RA/en unknown
- 2015-03-25 MX MX2016012314A patent/MX378539B/es unknown
- 2015-03-25 EP EP15720489.2A patent/EP3122764B1/en not_active Not-in-force
- 2015-03-25 PT PT15720489T patent/PT3122764T/pt unknown
- 2015-03-25 BR BR112016021835A patent/BR112016021835A8/pt not_active IP Right Cessation
- 2015-03-25 JP JP2016555315A patent/JP6740133B2/ja not_active Expired - Fee Related
- 2015-03-25 WO PCT/NL2015/050191 patent/WO2015147641A1/en not_active Ceased
- 2015-03-25 DK DK15720489.2T patent/DK3122764T3/en active
- 2015-03-25 CA CA2941080A patent/CA2941080A1/en not_active Abandoned
- 2015-03-25 KR KR1020167027533A patent/KR20160135742A/ko not_active Ceased
- 2015-03-25 CN CN201580016044.6A patent/CN106170492B/zh not_active Expired - Fee Related
-
2016
- 2016-06-27 IL IL246487A patent/IL246487A0/en unknown
- 2016-10-18 ZA ZA2016/07177A patent/ZA201607177B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3122764T (pt) | 2019-04-26 |
| IL246487A0 (en) | 2016-08-31 |
| EP3122764A1 (en) | 2017-02-01 |
| RU2016139223A (ru) | 2018-04-26 |
| CA2941080A1 (en) | 2015-10-01 |
| KR20160135742A (ko) | 2016-11-28 |
| HUE042615T2 (hu) | 2019-07-29 |
| RU2697515C2 (ru) | 2019-08-15 |
| SG11201605195RA (en) | 2016-10-28 |
| US20170107257A1 (en) | 2017-04-20 |
| HRP20190544T1 (hr) | 2019-05-31 |
| WO2015147641A1 (en) | 2015-10-01 |
| SG10201808383UA (en) | 2018-10-30 |
| EP3122764B1 (en) | 2019-01-16 |
| MX378539B (es) | 2025-03-10 |
| AU2015237357A1 (en) | 2016-07-07 |
| BR112016021835A8 (pt) | 2018-08-28 |
| DK3122764T3 (en) | 2019-04-15 |
| ZA201607177B (en) | 2019-07-31 |
| PL3122764T3 (pl) | 2019-07-31 |
| ES2719137T3 (es) | 2019-07-08 |
| CN106170492B (zh) | 2020-08-21 |
| JP6740133B2 (ja) | 2020-08-12 |
| RU2016139223A3 (es) | 2018-10-12 |
| JP2017512760A (ja) | 2017-05-25 |
| CN106170492A (zh) | 2016-11-30 |
| AU2015237357B2 (en) | 2019-04-18 |
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