MX2017001279A - Usos y composiciones de la flagelina. - Google Patents
Usos y composiciones de la flagelina.Info
- Publication number
- MX2017001279A MX2017001279A MX2017001279A MX2017001279A MX2017001279A MX 2017001279 A MX2017001279 A MX 2017001279A MX 2017001279 A MX2017001279 A MX 2017001279A MX 2017001279 A MX2017001279 A MX 2017001279A MX 2017001279 A MX2017001279 A MX 2017001279A
- Authority
- MX
- Mexico
- Prior art keywords
- compositons
- flagellin
- flagelin
- compositions
- treatment
- Prior art date
Links
- 108010040721 Flagellin Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a composiciones que comprenden constructos mejorados derivados de la flagelina y métodos de uso en el tratamiento de diversas enfermedades.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031116P | 2014-07-30 | 2014-07-30 | |
| US201562110744P | 2015-02-02 | 2015-02-02 | |
| US201562117366P | 2015-02-17 | 2015-02-17 | |
| PCT/US2015/042684 WO2016019034A1 (en) | 2014-07-30 | 2015-07-29 | Flagellin compositons and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017001279A true MX2017001279A (es) | 2017-08-07 |
| MX385845B MX385845B (es) | 2025-03-18 |
Family
ID=55218277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017001279A MX385845B (es) | 2014-07-30 | 2015-07-29 | Usos y composiciones de la flagelina |
| MX2017001406A MX2017001406A (es) | 2014-07-30 | 2015-07-30 | Agentes a base de flagelina y usos de los mismos, incluyendo vacunación efectiva. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017001406A MX2017001406A (es) | 2014-07-30 | 2015-07-30 | Agentes a base de flagelina y usos de los mismos, incluyendo vacunación efectiva. |
Country Status (14)
| Country | Link |
|---|---|
| US (9) | US10202426B2 (es) |
| EP (2) | EP3174893B1 (es) |
| JP (3) | JP6940916B2 (es) |
| KR (1) | KR20170031251A (es) |
| CN (2) | CN107087411B (es) |
| AU (2) | AU2015296555B2 (es) |
| BR (1) | BR112017001796A2 (es) |
| CA (2) | CA2994218A1 (es) |
| EA (2) | EA035372B1 (es) |
| ES (1) | ES2816630T3 (es) |
| IL (2) | IL250331B (es) |
| MX (2) | MX385845B (es) |
| WO (2) | WO2016019034A1 (es) |
| ZA (1) | ZA201701286B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3174893B1 (en) * | 2014-07-30 | 2020-05-06 | Genome Protection, Inc. | Flagellin compositions and uses |
| US11058758B2 (en) | 2014-11-20 | 2021-07-13 | National Institutes Of Biomedical Innovation, Health And Nutrition | TH1-inducing adjuvant comprising combination of different nucleic acid adjuvants, and use of same |
| UY37816A (es) * | 2017-07-20 | 2019-02-28 | Spogen Biotech Inc | Polipéptidos bioactivos para mejorar la protección, crecimiento y productividad en plantas |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| US11660331B2 (en) | 2017-11-09 | 2023-05-30 | The Scripps Research Institute | Heroin vaccine |
| JP7037930B2 (ja) * | 2017-12-19 | 2022-03-17 | 株式会社小糸製作所 | 車両の運転支援装置、命令表示装置及び車両用灯具。 |
| CN109879940A (zh) * | 2017-12-25 | 2019-06-14 | 苏州和锐生物科技有限公司 | 鞭毛g多肽、抗体捕获器件及试剂盒 |
| SG11202010485VA (en) * | 2018-04-24 | 2020-11-27 | Genome Protection Inc | Methods for improving frailty and aging |
| WO2020110154A1 (en) * | 2018-11-30 | 2020-06-04 | Bharat Biotech International Limited | A chimeric therapeutic vaccine |
| WO2020118192A1 (en) * | 2018-12-07 | 2020-06-11 | Genome Protection, Inc. | Engineered flagellin-derived compositions and uses |
| CN111718417B (zh) * | 2019-03-19 | 2022-10-14 | 宁波鲲鹏生物科技有限公司 | 含有荧光蛋白片段的融合蛋白及其用途 |
| KR102169663B1 (ko) * | 2019-03-28 | 2020-10-26 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물 |
| WO2020212952A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Treatment of depression and other various disorders with psilocybin |
| CN110157655B (zh) * | 2019-05-22 | 2021-06-01 | 中国兽医药品监察所 | 一种无毒性气肿疽梭菌基因工程亚单位疫苗用菌种及其应用 |
| CN114502573A (zh) * | 2019-08-30 | 2022-05-13 | 基因组保护股份有限公司 | 提高疫苗功效的方法 |
| AU2021276656A1 (en) | 2020-05-19 | 2022-11-24 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| KR102720967B1 (ko) * | 2020-06-04 | 2024-10-23 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 면역관문억제제의 항암 효과 증진용 약학 조성물 |
| TWI746188B (zh) * | 2020-09-28 | 2021-11-11 | 中山醫學大學 | 篩選治療腦炎藥物之平台及其方法 |
| US20220226465A1 (en) | 2021-01-18 | 2022-07-21 | ConserV Bioscience | Coronavirus Immunogenic Compositions, Methods and Uses Thereof |
| KR20240027752A (ko) * | 2021-06-30 | 2024-03-04 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 플라겔린의 폐 전달을 위한 에어로졸 조성물 |
| KR102483177B1 (ko) * | 2021-07-09 | 2022-12-29 | 전남대학교산학협력단 | 탈-면역 플라젤린 및 이를 포함하는 백신 조성물 |
| KR102514849B1 (ko) * | 2021-10-28 | 2023-03-28 | 전남대학교산학협력단 | 수지상 세포를 표적하는 신규한 펩타이드, 및 이를 포함하는 암 치료용 조성물 |
| IL317229A (en) * | 2022-06-01 | 2025-01-01 | Flag Bio Inc | RNA helpers, methods and uses thereof |
| KR20240022417A (ko) * | 2022-08-10 | 2024-02-20 | 주식회사 메디스팬 | 바실러스 서브틸리스 플라젤린 변이체 및 이의 용도 |
| WO2025172452A1 (en) * | 2024-02-14 | 2025-08-21 | Institut National de la Santé et de la Recherche Médicale | Combination for treating bacterial infection due to pseudomonas aeruginosa antibiotic-resistant strain |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007812A (en) | 1957-02-11 | 1961-11-07 | Allied Chem | Water-repellent compositions, method of water-proofing porous surfaces therewith, and resulting water-repellent surfaces |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5399494A (en) | 1983-03-04 | 1995-03-21 | The University Of Maryland System | Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom |
| US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
| DE59107966D1 (de) | 1990-09-28 | 1996-08-01 | Sulzer Innotec Ag | Hohlnadel zur medizinischen verwendung und verfahren zur herstellung derartiger hohlnadeln |
| WO1993018150A1 (en) | 1992-03-02 | 1993-09-16 | Biocine S.P.A. | Helicobacter pylori proteins useful for vaccines and diagnostics |
| US5693476A (en) | 1995-02-24 | 1997-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of screening for compounds capable of modulating vesicular release |
| US20020009747A1 (en) | 1997-08-25 | 2002-01-24 | Freda Diane Miller | Methods and reagents for identifying modulators of neuronal apoptosis |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| AU4709401A (en) | 1999-11-29 | 2001-06-12 | Inotek Corporation | Composition and method for treating a microbial infection |
| CA2398660A1 (en) | 2000-01-31 | 2001-08-02 | Munin Corporation | Human cyr61 |
| US7300749B2 (en) | 2000-02-17 | 2007-11-27 | Millennium Pharmaceuticals, Inc. | Molecules of the pyrin domain protein family and uses thereof |
| WO2002044363A1 (en) | 2000-11-28 | 2002-06-06 | Genesis Research And Development Corporation Limited | Methods for modulating apoptotic cell death |
| EP1379552B2 (en) | 2001-04-20 | 2014-11-19 | The Institute for Systems Biology | Toll-like receptor 5 ligands and methods of use |
| US8703146B2 (en) | 2001-04-20 | 2014-04-22 | Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| WO2003028659A2 (en) | 2001-10-02 | 2003-04-10 | University Of Chicago | Methods and compositions for modulating apoptosis |
| US7078165B2 (en) | 2003-03-27 | 2006-07-18 | Institut Pasteur | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof |
| WO2005056054A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING INDUCERS OF NF-κB |
| CN1913915B (zh) | 2003-12-02 | 2010-12-01 | 克里夫兰临床基金会 | 使用鞭毛蛋白防止辐射的方法 |
| US8580321B2 (en) | 2003-12-02 | 2013-11-12 | The Cleveland Clinic Foundation | Method for reducing the effects of chemotherapy using flagellin related polypeptides |
| WO2005056041A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING LATENT TGFβ |
| US7638485B2 (en) | 2003-12-02 | 2009-12-29 | Cleveland Biolabs, Inc. | Modulating apoptosis |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| US7404963B2 (en) | 2004-10-01 | 2008-07-29 | The University Of South Florida | Flagellin-based adjuvants and vaccines |
| US20080220011A1 (en) | 2004-12-16 | 2008-09-11 | Mizel Steven B | Use of Flagellin in Tumor Immunotherapy |
| EP2460534A1 (en) | 2004-12-22 | 2012-06-06 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| JP2009507848A (ja) | 2005-09-09 | 2009-02-26 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 神経保護薬 |
| WO2007070623A2 (en) | 2005-12-14 | 2007-06-21 | Medistem Laboratories, Inc. | Transcatheter tumor immunoembolization |
| EP1979488A4 (en) | 2006-01-09 | 2009-05-27 | Univ California | IMMUNOSTIMULATING COMBINATIONS OF TNFRSF, TLR, NLR, RHR, PURINERIC RECEPTOR, AND CYTOKIN RECEPTOR ANTONISTS FOR VACCINES AND TUMOR IMMUNOTHERAPY |
| US8389482B2 (en) | 2007-01-30 | 2013-03-05 | New York University | Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species |
| KR20100034010A (ko) | 2007-06-15 | 2010-03-31 | 임뮤룩스, 인코포레이티드 | Tnfr 효능제 치료 요법의 독성을 경감시키기 위한 tlr 효능제 및/또는 타입 1 인터페론의 용도 |
| TR201000668T1 (tr) | 2007-07-31 | 2010-06-21 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Neoplasti̇k veya enfeksi̇yoz bozukluklara yöneli̇k i̇mmunoprofi̇laksi̇ veya i̇mmünoterapi̇ i̇çi̇n poli̇pepti̇d-nüklei̇k asi̇t konjugati |
| NZ599777A (en) | 2007-11-07 | 2013-09-27 | Celldex Therapeutics Inc | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| JP5577337B2 (ja) | 2008-08-01 | 2014-08-20 | クリーブランド バイオラブス, インコーポレイテッド | 再灌流傷害を治療するための方法 |
| CA2739454C (en) | 2008-10-03 | 2018-05-01 | Emory University | Methods for the treatment of graft-versus-host disease |
| CN102482233A (zh) | 2009-05-21 | 2012-05-30 | 阿斯利康(瑞典)有限公司 | 新颖的嘧啶衍生物和它们在治疗癌症和其它疾病中的用途 |
| CN102844047B (zh) | 2009-09-02 | 2017-04-05 | 诺华股份有限公司 | 含tlr活性调节剂的免疫原性组合物 |
| CA2777198C (en) * | 2009-10-06 | 2018-07-24 | Panacela Labs, Inc. | Use of toll-like receptor and agonist for treating cancer |
| EP2547362B1 (en) * | 2010-03-17 | 2021-08-25 | Cornell University | Disrupted adenovirus-based vaccine against drugs of abuse |
| US9683020B2 (en) * | 2011-08-01 | 2017-06-20 | Emory University | VLPS containing ligands and methods related thereto |
| CN102965386A (zh) * | 2011-09-02 | 2013-03-13 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种重组细菌鞭毛蛋白衍生多肽的制备和活性鉴定方法 |
| CN102772795B (zh) * | 2012-08-06 | 2015-07-29 | 中国人民解放军疾病预防控制所 | 布鲁氏菌鞭毛蛋白bmeii1112在制备布鲁氏菌亚单位疫苗中的应用 |
| EP3174893B1 (en) * | 2014-07-30 | 2020-05-06 | Genome Protection, Inc. | Flagellin compositions and uses |
-
2015
- 2015-07-29 EP EP15827248.4A patent/EP3174893B1/en active Active
- 2015-07-29 CA CA2994218A patent/CA2994218A1/en active Pending
- 2015-07-29 AU AU2015296555A patent/AU2015296555B2/en not_active Ceased
- 2015-07-29 JP JP2017504404A patent/JP6940916B2/ja not_active Expired - Fee Related
- 2015-07-29 WO PCT/US2015/042684 patent/WO2016019034A1/en not_active Ceased
- 2015-07-29 US US15/329,870 patent/US10202426B2/en active Active
- 2015-07-29 CN CN201580048628.1A patent/CN107087411B/zh not_active Expired - Fee Related
- 2015-07-29 BR BR112017001796-2A patent/BR112017001796A2/pt not_active Application Discontinuation
- 2015-07-29 ES ES15827248T patent/ES2816630T3/es active Active
- 2015-07-29 KR KR1020177005615A patent/KR20170031251A/ko not_active Ceased
- 2015-07-29 MX MX2017001279A patent/MX385845B/es unknown
- 2015-07-29 EA EA201790273A patent/EA035372B1/ru unknown
- 2015-07-30 CA CA2994289A patent/CA2994289C/en active Active
- 2015-07-30 US US15/500,133 patent/US10336793B2/en active Active
- 2015-07-30 WO PCT/US2015/042887 patent/WO2016019134A1/en not_active Ceased
- 2015-07-30 EA EA201790294A patent/EA037407B1/ru unknown
- 2015-07-30 JP JP2017504354A patent/JP6646039B2/ja not_active Expired - Fee Related
- 2015-07-30 CN CN201580052842.4A patent/CN107073092A/zh active Pending
- 2015-07-30 EP EP15827000.9A patent/EP3174552B1/en active Active
- 2015-07-30 AU AU2015296298A patent/AU2015296298B2/en not_active Ceased
- 2015-07-30 MX MX2017001406A patent/MX2017001406A/es unknown
-
2017
- 2017-01-29 IL IL250331A patent/IL250331B/en active IP Right Grant
- 2017-01-29 IL IL250334A patent/IL250334B/en unknown
- 2017-02-21 ZA ZA2017/01286A patent/ZA201701286B/en unknown
-
2018
- 2018-06-25 US US16/017,251 patent/US20180354995A1/en not_active Abandoned
- 2018-12-20 US US16/226,909 patent/US10669316B2/en not_active Expired - Fee Related
-
2019
- 2019-05-16 US US16/414,403 patent/US10730915B2/en not_active Expired - Fee Related
-
2020
- 2020-02-27 US US16/802,859 patent/US11034733B2/en not_active Expired - Fee Related
- 2020-06-24 US US16/910,347 patent/US10975127B2/en not_active Expired - Fee Related
-
2021
- 2021-03-09 US US17/195,935 patent/US11542306B2/en active Active
- 2021-05-13 US US17/319,250 patent/US20210340190A1/en not_active Abandoned
- 2021-09-01 JP JP2021142801A patent/JP2021191781A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2017001279A (es) | Usos y composiciones de la flagelina. | |
| CY1120529T1 (el) | Προφαρμακα φουμαρικων αλατων και η χρηση τους στην αγωγη ποικιλων νοσων | |
| CL2016002027A1 (es) | Ciclopropilamina como inhibidor de la lsd1 | |
| MX2017008444A (es) | Picolinamidas como fungicidas. | |
| BR112017000456A2 (pt) | composições antivirais tópicas e métodos de uso das mesmas | |
| MX2016009625A (es) | Proteinas quimericas tipo fosfatasa alcalina. | |
| BR112017005266A2 (pt) | inibidores de mk2 e uso dos mesmos | |
| UY36330A (es) | Compuestos inhibidores de quinasa de unión a tank | |
| EA201692526A1 (ru) | Замещенные [1,2,4]триазольные соединения | |
| MX2018003700A (es) | Compuestos eficaces en el tratamiento de la hepatotoxicidad y enfermedades de higado graso, y uso de los mismos. | |
| BR112016017112A2 (pt) | Composições de apilimod e métodos de uso das mesmas | |
| PH12017500836A1 (en) | Transdermal formulations | |
| MX2019007571A (es) | Polimorfos. | |
| MX2021000773A (es) | Composiciones que comprenden acido 15-hidroxieicosapentaenoico (15-hepe) y metodos de uso del mismo. | |
| EA201791174A1 (ru) | Антимикотическое соединение | |
| BR112017009000A2 (pt) | apilimod para uso no tratamento de melanoma | |
| MX379126B (es) | Formulación de factor viii. | |
| MX2018005987A (es) | Compuestos heterociclicos para el tratamiento de enfermedades. | |
| BR112017024126A2 (pt) | composições farmacêuticas e uso das mesmas | |
| PH12016501434A1 (en) | Compositions for use in the treatment of allergic conditions | |
| EA201590615A1 (ru) | Стимулирующие лактацию композиции на основе фосфатидилсерина | |
| MX383460B (es) | Derivados peptidicos novedosos y sus usos. | |
| MX2017011903A (es) | Composiciones para el tratamiento de enfermedades renales y/o hepaticas. | |
| BR112017013194A2 (pt) | síntese total de trioxacarcina dc-45-a2 e preparação de análogos de trioxacarcina | |
| CR20150352A (es) | Nuevas composiciones antifúngicidas |