[go: up one dir, main page]

MX2016011549A - Derivados de piperidina como antagonistas de receptores de orexina. - Google Patents

Derivados de piperidina como antagonistas de receptores de orexina.

Info

Publication number
MX2016011549A
MX2016011549A MX2016011549A MX2016011549A MX2016011549A MX 2016011549 A MX2016011549 A MX 2016011549A MX 2016011549 A MX2016011549 A MX 2016011549A MX 2016011549 A MX2016011549 A MX 2016011549A MX 2016011549 A MX2016011549 A MX 2016011549A
Authority
MX
Mexico
Prior art keywords
piperidine derivatives
orexin receptor
receptor antagonist
hypersomnia
obsessive
Prior art date
Application number
MX2016011549A
Other languages
English (en)
Inventor
Zhang Yang
Lan Jiong
He Haiying
Lv Qiang
Wu Songliang
Ma Biao
Chen Yuan
Wang Yuhe
Liu Xing
Chen Shuhui
Original Assignee
Shanghai Haiyan Pharmaceutical Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54054589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016011549(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shanghai Haiyan Pharmaceutical Tech Co Ltd filed Critical Shanghai Haiyan Pharmaceutical Tech Co Ltd
Publication of MX2016011549A publication Critical patent/MX2016011549A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención describe una serie de derivados de piperidina como antagonistas del receptor de orexina y composiciones de los mismos y se refiere a la aplicación de los mismos en la preparación de medicamentos para el tratamiento del insomnio, enfermedad pulmonar obstructiva crónica, apnea obstructiva del sueño, hipersomnia, ansiedad, trastorno obsesivo-compulsivo, ataque de pánico, adicción a la nicotina o trastorno de atracones de comida.
MX2016011549A 2014-03-06 2015-02-27 Derivados de piperidina como antagonistas de receptores de orexina. MX2016011549A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410081220 2014-03-06
PCT/CN2015/073330 WO2015131773A1 (zh) 2014-03-06 2015-02-27 作为食欲素受体拮抗剂的哌啶衍生物

Publications (1)

Publication Number Publication Date
MX2016011549A true MX2016011549A (es) 2017-05-08

Family

ID=54054589

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011549A MX2016011549A (es) 2014-03-06 2015-02-27 Derivados de piperidina como antagonistas de receptores de orexina.

Country Status (16)

Country Link
US (1) US10100047B2 (es)
EP (1) EP3115362B1 (es)
JP (1) JP6262885B2 (es)
KR (1) KR101920472B1 (es)
CN (1) CN106414439B (es)
AU (1) AU2015226679B2 (es)
CA (1) CA2941663C (es)
CL (1) CL2016002240A1 (es)
IL (1) IL247584A0 (es)
MX (1) MX2016011549A (es)
NZ (1) NZ723671A (es)
PE (1) PE20170184A1 (es)
RU (1) RU2669701C2 (es)
SG (2) SG10201900536TA (es)
WO (1) WO2015131773A1 (es)
ZA (1) ZA201606141B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2852054T3 (es) 2013-03-15 2021-09-10 Global Blood Therapeutics Inc Compuestos y usos de los mismos para la modulación de hemoglobina
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
WO2017012502A1 (en) 2015-07-17 2017-01-26 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
CN111499625B (zh) 2015-08-14 2022-09-02 上海海雁医药科技有限公司 食欲素受体拮抗剂受体化合物的制备方法及其中间体和晶型
JP6936224B2 (ja) 2015-11-23 2021-09-15 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． オクタヒドロピロロ［３，４−ｃ］ピロール誘導体およびその使用
US10508083B2 (en) 2016-02-04 2019-12-17 Takeda Pharmaceutical Company Limited Substituted piperidine compound and use thereof
KR102876124B1 (ko) * 2020-04-17 2025-10-24 상하이 하이옌 파마슈티컬 테크놀로지 컴퍼니, 리미티드 고형 약물 제제 및 이의 제조 방법과 용도
CN112480107B (zh) * 2020-11-30 2022-08-16 上海海雁医药科技有限公司 取代的氮杂双环辛烷化合物及其中间体和制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2525124A1 (en) * 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
US20090247499A1 (en) * 2006-08-21 2009-10-01 Fletcher Joan M Sulfonylated piperazines as cannabinoid-1 receptor modulators
CA2688776A1 (en) * 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
EP2150115B1 (en) * 2007-05-23 2013-09-18 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
WO2008147518A1 (en) * 2007-05-23 2008-12-04 Merck & Co., Inc. Pyridyl piperidine orexin receptor antagonists
AU2009211724B2 (en) * 2008-02-06 2013-05-16 Msd K.K. 3-substituted sulfonyl piperazine derivative
CN101965343A (zh) 2008-02-21 2011-02-02 埃科特莱茵药品有限公司 2-氮杂-双环[2.2.1]庚烷衍生物
JP2012506374A (ja) * 2008-10-21 2012-03-15 メルク・シャープ・エンド・ドーム・コーポレイション ２，５−二置換ピペリジンオレキシン受容体アンタゴニスト
EP2348856B1 (en) * 2008-10-21 2013-08-14 Merck Sharp & Dohme Corp. 2,4-disubstituted pyrrolidine orexin receptor antagonists
CA2739916A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. 2,5-disubstituted piperidine orexin receptor antagonists
WO2010048016A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. 2,3-disubstituted piperidine orexin receptor antagonists
JP5899202B2 (ja) * 2010-04-29 2016-04-06 ザ ユニバーシティ オブ エディンバラ １１β−ＨＳＤ１の阻害剤としての３，３−二置換−（８−アザ−ビシクロ［３．２．１］オクタ−８−イル）−［５−（１Ｈ−ピラゾール−４−イル）−チオフェン−３−イル］−メタノン類
AU2011283684B2 (en) * 2010-07-29 2015-08-27 Rigel Pharmaceuticals, Inc. AMPK-activating heterocyclic compounds and methods for using the same
WO2013005755A1 (ja) * 2011-07-05 2013-01-10 大正製薬株式会社 メチルピペリジン誘導体
AR088352A1 (es) * 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
TW201326151A (zh) * 2011-10-25 2013-07-01 Shionogi & Co 具有ｐｇｄ２受體拮抗活性之雜環衍生物
JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
AU2013347538B2 (en) * 2012-11-16 2017-04-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
TWI621618B (zh) * 2013-03-13 2018-04-21 比利時商健生藥品公司 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途

Also Published As

Publication number Publication date
AU2015226679B2 (en) 2017-05-25
AU2015226679A1 (en) 2016-09-15
KR20160143668A (ko) 2016-12-14
CA2941663A1 (en) 2015-09-11
EP3115362A4 (en) 2017-08-16
JP6262885B2 (ja) 2018-01-17
NZ723671A (en) 2017-05-26
CN106414439B (zh) 2017-12-08
CL2016002240A1 (es) 2017-02-17
PE20170184A1 (es) 2017-04-07
EP3115362B1 (en) 2019-06-12
KR101920472B1 (ko) 2019-02-08
IL247584A0 (en) 2016-11-30
SG11201607183PA (en) 2016-10-28
RU2669701C2 (ru) 2018-10-15
CN106414439A (zh) 2017-02-15
US20170233385A1 (en) 2017-08-17
ZA201606141B (en) 2017-05-31
US10100047B2 (en) 2018-10-16
JP2017507185A (ja) 2017-03-16
RU2016130937A (ru) 2018-04-09
EP3115362A1 (en) 2017-01-11
WO2015131773A1 (zh) 2015-09-11
CA2941663C (en) 2020-02-18
SG10201900536TA (en) 2019-02-27

Similar Documents

Publication Publication Date Title
NZ723671A (en) Piperidine derivatives as orexin receptor antagonist
ZA201907158B (en) Methods and compositions for treating sleep apnea
PL2883853T3 (pl) Gruboziarnisty ceramiczny wyrób ogniotrwały i sposób jego wytwarzania oraz jego zastosowanie
PH12014501595A1 (en) Substituted annulated pyrimidines and triazines, and use thereof
EP4382164A3 (en) Methods for treating or preventing asthma by administering an il-4r antagonist
IL266302B (en) History of glutarimide, their use, pharmaceutical preparation based on them and methods for producing history of glutarimide
MA32975B1 (fr) Antagonistes de c5ar
IL268928B1 (en) Crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-piperidin-1-yl)-propanone and their use
WO2014120936A3 (en) Treatments for depression and other diseases with a low dose agent
PH12016500065A1 (en) Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof
CN110799501A (zh) 一种食欲素受体拮抗剂的晶型及其制备方法和用途
UA111434C2 (uk) Фармацевтична композиція, що містить фімасартан і гідрохлортіазид
IL253688A (en) New preparations and methods for the treatment or prevention of chronic obstructive pulmonary diseases
CL2014003607A1 (es) Compuestos derivados de benzodioxol, inhibidores de la acetilcolinesterasa; metodo de preparacion; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o el tratamiento de la enfermedad de alzheimer.
MX371102B (es) Nuevos derivados de bencimidazol como agentes antihistaminicos.
PH12014502351B1 (en) Methods of producing anamorelin hydrochloride having controlled chloride content
TN2014000532A1 (en) N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products
MX2017017155A (es) Antagonistas del receptor de tromboxano en erea/asma.
IL235257A (en) Snoring and sleep apnea system
IL248662A0 (en) Compounds and related methods of their preparation for the prevention or treatment of nicotine addiction
UA29004S (uk) Подушка ортопедична «sweeten»
CN302457116S (zh) 店面门头
CN302567684S (zh) 吊挂门用上轨道