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MX2016008462A - Modulacion de la expresion similar a la angiopoyetina tipo 3. - Google Patents

Modulacion de la expresion similar a la angiopoyetina tipo 3.

Info

Publication number
MX2016008462A
MX2016008462A MX2016008462A MX2016008462A MX2016008462A MX 2016008462 A MX2016008462 A MX 2016008462A MX 2016008462 A MX2016008462 A MX 2016008462A MX 2016008462 A MX2016008462 A MX 2016008462A MX 2016008462 A MX2016008462 A MX 2016008462A
Authority
MX
Mexico
Prior art keywords
expression
compositions
compounds
methods
angiopoietin
Prior art date
Application number
MX2016008462A
Other languages
English (en)
Other versions
MX383753B (es
Inventor
M Freier Susan
M Crooke Rosanne
J Graham Mark
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2016008462A publication Critical patent/MX2016008462A/es
Publication of MX383753B publication Critical patent/MX383753B/es

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/50—Methods for regulating/modulating their activity
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Abstract

En la presente se proporcionan métodos, compuestos y composiciones para reducir la expresión de una proteína y ARNm de ANGPTL3 en un animal. También se proporcionan en la presente métodos, compuestos y composiciones para reducir los lípidos y/o la glucosa en un animal. Dichos métodos, compuestos y composiciones son útiles para el tratamiento, prevención, retraso o mejora de cualesquiera una o más de enfermedad cardiovascular o enfermedad metabólica, o un síntoma de estas, en un individuo que lo necesite.
MX2016008462A 2013-12-24 2014-12-24 Modulación de la expresión similar a la angiopoyetina tipo 3. MX383753B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920652P 2013-12-24 2013-12-24
PCT/US2014/072303 WO2015100394A1 (en) 2013-12-24 2014-12-24 Modulation of angiopoietin-like 3 expression

Publications (2)

Publication Number Publication Date
MX2016008462A true MX2016008462A (es) 2016-10-12
MX383753B MX383753B (es) 2025-03-14

Family

ID=53479686

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016008462A MX383753B (es) 2013-12-24 2014-12-24 Modulación de la expresión similar a la angiopoyetina tipo 3.

Country Status (19)

Country Link
US (3) US20170037409A1 (es)
EP (2) EP3087183B1 (es)
JP (2) JP6643996B2 (es)
KR (2) KR102298476B1 (es)
CN (3) CN111394355A (es)
AU (2) AU2014369900B2 (es)
BR (1) BR112016013473A2 (es)
CA (1) CA2931510A1 (es)
DK (1) DK3087183T3 (es)
ES (1) ES2830257T3 (es)
HU (1) HUE052243T2 (es)
IL (2) IL245707B (es)
MX (1) MX383753B (es)
NZ (1) NZ720286A (es)
PL (1) PL3087183T3 (es)
PT (1) PT3087183T (es)
RU (1) RU2706964C2 (es)
SI (1) SI3087183T1 (es)
WO (1) WO2015100394A1 (es)

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AU2017227713B2 (en) 2016-03-03 2022-12-22 Regeneron Pharmaceuticals, Inc. Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor
RS66975B1 (sr) * 2016-04-28 2025-07-31 Regeneron Pharma Postupci za lečenje pacijenata sa porodičnom hiperholesterolemijom
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
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JP7261494B2 (ja) * 2017-12-01 2023-04-20 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
US11414665B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
WO2019105437A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019128611A1 (en) 2017-12-29 2019-07-04 Suzhou Ribo Life Science Co., Ltd. Conjugates and preparation and use thereof
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JP7376952B2 (ja) 2018-09-30 2023-11-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド ｓｉＲＮＡ複合体及びその調製方法と使用
WO2020099525A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Oligonucleotides influencing the regulation of the fatty acid metabolism
WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
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CN113227376B (zh) 2019-05-22 2024-04-09 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN111973617A (zh) * 2019-05-23 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
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CN113956345B (zh) * 2021-09-10 2024-04-23 北京大学 Angpt4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用
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JP2025507751A (ja) 2022-03-01 2025-03-21 クリスパー・セラピューティクス・アクチェンゲゼルシャフト アンジオポエチン様３（ａｎｇｐｔｌ３）関連状態を処置するための方法および組成物
KR20250054795A (ko) * 2022-08-22 2025-04-23 애로우헤드 파마슈티컬스 인코포레이티드 Angptl3-관련 질환 및 장애의 치료 방법
KR20250099703A (ko) 2022-11-10 2025-07-02 리제너론 파마슈티칼스 인코포레이티드 안지오포이에틴 유사 3(angptl3) 억제제 및 용질 운반체 패밀리 5 구성원 2(slc5a2) 억제제의 조합을 이용한 신장 질환의 치료

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