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MX2016002586A - Métodos y composiciones para el tratamiento guiado por rna de infección por hiv. - Google Patents

Métodos y composiciones para el tratamiento guiado por rna de infección por hiv.

Info

Publication number
MX2016002586A
MX2016002586A MX2016002586A MX2016002586A MX2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A
Authority
MX
Mexico
Prior art keywords
compositions
rna
methods
hiv infection
guided treatment
Prior art date
Application number
MX2016002586A
Other languages
English (en)
Inventor
Kamel Khalili
Wenhui Hu
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Publication of MX2016002586A publication Critical patent/MX2016002586A/es

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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16061—Methods of inactivation or attenuation
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Abstract

La presente invención describe métodos y composiciones para el tratamiento de infección por virus de inmunodeficiencia. Las composiciones incluyen secuencias de ácido nucleico aislado que comprenden endonucleasa asociada con CRISPR y un ARN de guía, en donde el ARN de guía es complementario a una secuencia objetivo en un virus de inmunodeficiencia humana.
MX2016002586A 2013-08-29 2014-08-29 Métodos y composiciones para el tratamiento guiado por rna de infección por hiv. MX2016002586A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361871626P 2013-08-29 2013-08-29
US201462018441P 2014-06-27 2014-06-27
US201462026103P 2014-07-18 2014-07-18
PCT/US2014/053441 WO2015031775A1 (en) 2013-08-29 2014-08-29 Methods and compositions for rna-guided treatment of hiv infection

Publications (1)

Publication Number Publication Date
MX2016002586A true MX2016002586A (es) 2016-06-14

Family

ID=52587370

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002586A MX2016002586A (es) 2013-08-29 2014-08-29 Métodos y composiciones para el tratamiento guiado por rna de infección por hiv.

Country Status (15)

Country Link
US (24) US9925248B2 (es)
EP (2) EP4385567A3 (es)
JP (3) JP7118588B2 (es)
KR (2) KR20160060659A (es)
CN (1) CN106102781A (es)
AU (2) AU2014312123A1 (es)
BR (1) BR112016004091A2 (es)
CA (1) CA2922428A1 (es)
CL (1) CL2016000424A1 (es)
EA (1) EA037850B1 (es)
IL (1) IL244220B (es)
MX (1) MX2016002586A (es)
SG (2) SG11201601313TA (es)
WO (1) WO2015031775A1 (es)
ZA (1) ZA201601344B (es)

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