[go: up one dir, main page]

MX2016000938A - Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona. - Google Patents

Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona.

Info

Publication number
MX2016000938A
MX2016000938A MX2016000938A MX2016000938A MX2016000938A MX 2016000938 A MX2016000938 A MX 2016000938A MX 2016000938 A MX2016000938 A MX 2016000938A MX 2016000938 A MX2016000938 A MX 2016000938A MX 2016000938 A MX2016000938 A MX 2016000938A
Authority
MX
Mexico
Prior art keywords
piperazin
triazol
ethanone derivatives
ethanone
derivatives
Prior art date
Application number
MX2016000938A
Other languages
English (en)
Other versions
MX363432B (es
Inventor
Eva Caroff
Emmanuel Meyer
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51225512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016000938(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2016000938A publication Critical patent/MX2016000938A/es
Publication of MX363432B publication Critical patent/MX363432B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención se refiere a compuestos de Fórmula (I) donde X, Y, R1, R2, R3, R4 y R5 son tal como se describen en la descripción; a sus sales farmacéuticamente aceptables, y al uso de dichos compuestos como medicamentos, especialmente como moduladores del receptor CXCR3. (ver Fórmula).
MX2016000938A 2013-07-22 2014-07-21 Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona. MX363432B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013056001 2013-07-22
PCT/EP2014/065639 WO2015011099A1 (en) 2013-07-22 2014-07-21 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives

Publications (2)

Publication Number Publication Date
MX2016000938A true MX2016000938A (es) 2016-05-05
MX363432B MX363432B (es) 2019-03-22

Family

ID=51225512

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000938A MX363432B (es) 2013-07-22 2014-07-21 Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona.

Country Status (22)

Country Link
US (1) US10259807B2 (es)
EP (1) EP3024832B1 (es)
JP (1) JP6330040B2 (es)
KR (1) KR102295416B1 (es)
CN (1) CN105658649B (es)
AR (1) AR096984A1 (es)
AU (1) AU2014295123B2 (es)
BR (1) BR112016001238B1 (es)
CA (1) CA2916338C (es)
CL (1) CL2016000152A1 (es)
EA (1) EA030067B1 (es)
ES (1) ES2671323T3 (es)
IL (1) IL243650A0 (es)
MA (1) MA38857B1 (es)
MX (1) MX363432B (es)
PH (1) PH12016500134A1 (es)
PL (1) PL3024832T3 (es)
SA (1) SA516370398B1 (es)
SG (1) SG11201600504TA (es)
TR (1) TR201807959T4 (es)
TW (1) TWI630205B (es)
WO (1) WO2015011099A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363432B (es) 2013-07-22 2019-03-22 Idorsia Pharmaceuticals Ltd Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona.
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
NZ734542A (en) * 2015-01-15 2023-02-24 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
WO2018011265A1 (en) 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002059107A1 (en) 2001-01-23 2002-08-01 Eli Lilly And Company Substituted piperidines/piperazines as melanocortin receptor agonists
ES2246390T3 (es) 2001-01-23 2006-02-16 Eli Lilly And Company Derivados de piperazina como agonistas del receptor de melanocortina.
JP2005511475A (ja) 2001-03-02 2005-04-28 ブリストル−マイヤーズ スクイブ カンパニー メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物
US20050256130A1 (en) 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
KR101255356B1 (ko) 2002-06-12 2013-04-17 케모센트릭스, 인크. 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
GB0315203D0 (en) 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
WO2005035534A1 (ja) 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
WO2005042516A2 (en) 2003-10-22 2005-05-12 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
CA2546754A1 (en) 2003-11-21 2005-06-09 Array Biopharma Inc. Akt protein kinase inhibitors
US20060276465A1 (en) 2003-12-26 2006-12-07 Eisai R&D Management Co., Ltd. 1,2-di(cyclic) substituted benzene compounds
MY140489A (en) 2003-12-26 2009-12-31 Eisai R&D Man Co Ltd 1,2-di (cyclic) substituted benzene compounds
US7645755B2 (en) 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
WO2006047277A2 (en) 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Inhibitors of c-fms kinase
CN101142209A (zh) 2005-02-16 2008-03-12 先灵公司 具有cxcr3拮抗剂活性的吡嗪基取代的哌嗪-哌啶
CA2598457A1 (en) 2005-02-16 2006-08-24 Schering Corporation Pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity
US7868006B2 (en) 2005-02-16 2011-01-11 Schering Corporation Heterocyclic substituted piperazines with CXCR3 antagonist activity
MX2007009949A (es) 2005-02-16 2007-09-26 Schering Corp Pirazinil-piperazin-piperidinas sustituidas con heteroarilo con actividad antagonista de cxcr3.
KR20070107075A (ko) 2005-02-16 2007-11-06 쉐링 코포레이션 Ｃｘｃｒ３ 길항제 활성을 갖는 신규의 헤테로사이클릭치환된 피리딘 또는 페닐 화합물
WO2006088920A1 (en) 2005-02-16 2006-08-24 Schering Corporation Amine-linked pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity
JP2008530212A (ja) 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有するピペラジン−ピペリジン
CA2598423C (en) * 2005-02-18 2014-05-27 Astrazeneca Ab Antibacterial piperidine derivatives
US7777035B2 (en) 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
AU2006262122B2 (en) 2005-06-22 2013-01-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
WO2007002742A1 (en) 2005-06-28 2007-01-04 Pharmacopeia, Inc. Substituted [1,4]-diazepanes as cxcr3 antagonists and their use in the treatment of inflammatory disorders
US7754724B2 (en) 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
JP2009511582A (ja) 2005-10-11 2009-03-19 シェーリング コーポレイション Ｃｘｃｒ３拮抗薬活性を有する置換複素環式化合物
NZ595182A (en) 2005-10-18 2012-12-21 Janssen Pharmaceutica Nv Pharmaceutical uses of 4-cyano-1H-imidazole-2-carboxylic acid { 2-cyclohex-1-enyl-4-[1-(2-dimethylamino-acetyl)-piperidin-4-yl]-phenyl} -amide
US20090143413A1 (en) 2005-11-29 2009-06-04 Adams Alan D Thiazole Derivatives as CXCR3 Receptor Modulators
EP1962605A2 (en) 2005-12-12 2008-09-03 Merck & Co., Inc. 2-arylthiazole derivatives as cxcr3 receptor modulators
WO2007076318A2 (en) 2005-12-21 2007-07-05 Smithkline Beecham Corporation Camphor-derived cxcr3 antagonists
EP1988900A2 (en) 2006-02-23 2008-11-12 Merck & Co., Inc. Pyridine, pyrimidine and pyrazine derivatives as cxcr3 receptor modulators
MX2008012161A (es) 2006-03-21 2008-10-03 Schering Corp Compuestos heterociclicos de piridina sustituida con actividad antagonista de cxcr3.
MX2008013528A (es) 2006-04-20 2008-10-29 Jannsen Pharmaceutica N V Metodo para inhibir la cinasa del c-kit.
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
FR2903405B1 (fr) 2006-07-04 2011-09-09 Pasteur Institut Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
EP2041117B1 (en) 2006-07-14 2012-08-22 Merck Sharp & Dohme Corp. Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
CN101558066A (zh) * 2006-08-17 2009-10-14 阿斯利康(瑞典)有限公司 具有抗菌活性的吡咯衍生物
US20120157466A1 (en) 2006-12-22 2012-06-21 Qingbei Zeng Heterocyclic compounds with cxcr3 antagonist activity
WO2008091594A2 (en) 2007-01-24 2008-07-31 E. I. Du Pont De Nemours And Company Fungicidal mixtures
PL2121660T3 (pl) 2007-01-25 2015-06-30 Du Pont Amidy grzybobójcze
WO2009020534A2 (en) 2007-08-03 2009-02-12 Schering Corporation Method of treating cxcr3 mediated diseases using heterocyclic substituted piperazines
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
EP2234971A1 (en) 2007-12-18 2010-10-06 Schering Corporation Process and intermediates for the synthesis of heterocyclic substituted piperazines with cxcr3 antagonist activity
EP2238133A2 (en) 2008-01-25 2010-10-13 E. I. du Pont de Nemours and Company Fungicidal amides
JP5529044B2 (ja) 2008-01-25 2014-06-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺菌性複素環化合物
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
WO2009132785A1 (de) 2008-04-30 2009-11-05 Bayer Cropscience Aktiengesellschaft Thiazol-4-carbonsäureester und thioester als pflanzenschutzmittel
EP2334669B1 (de) 2008-10-01 2015-12-23 Bayer Intellectual Property GmbH Heterocyclyl substituierte thiazole als pflanzenschutzmittel
KR101052065B1 (ko) 2008-10-15 2011-07-27 한국과학기술연구원 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법
UY32285A (es) 2008-12-02 2010-06-30 Du Pont Compuestos heterocíclicos fungicidas
BRPI0923366A2 (pt) 2008-12-11 2019-09-24 Bayer Cropscience Ag éteres e hodrazonas de oxima de tiazolila como agentes protetors de culturas.
EP2424840B1 (en) 2009-04-27 2014-08-06 Boehringer Ingelheim International GmbH Cxcr3 receptor antagonists
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
EP2272846A1 (de) 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidin Derivate als Fungizide
UA107938C2 (en) 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
NZ597562A (en) 2009-08-12 2013-10-25 Syngenta Participations Ag Microbiocidal heterocycles
WO2011051243A1 (en) 2009-10-29 2011-05-05 Bayer Cropscience Ag Active compound combinations
CN102712634B (zh) 2009-10-30 2016-04-06 拜耳知识产权有限责任公司 杂芳基哌啶和杂芳基哌嗪衍生物
CN102781937B (zh) 2009-12-21 2015-09-30 拜尔农作物科学股份公司 用作杀菌剂的双(二氟甲基)吡唑
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
WO2011134969A1 (de) 2010-04-28 2011-11-03 Bayer Cropscience Ag Ketoheteroarylpiperidin und -piperazin derivate als fungizide
US8815775B2 (en) 2010-05-18 2014-08-26 Bayer Cropscience Ag Bis(difluoromethyl)pyrazoles as fungicides
AU2011256730B2 (en) 2010-05-20 2015-07-09 E. I. Du Pont De Nemours And Company Fungicidal oximes and hydrazones
WO2011147765A1 (de) 2010-05-27 2011-12-01 Bayer Cropscience Ag Pyridinylcarbonsäure derivate als fungizide
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
MX352731B (es) 2010-10-27 2017-12-06 Bayer Ip Gmbh Derivados de heteroarilpiperidina y -piperazina como fungicidas.
EP2643312B1 (en) 2010-11-25 2014-09-10 Syngenta Participations AG Microbicidal heterocycles
CN103384470A (zh) 2010-12-17 2013-11-06 纳幕尔杜邦公司 杀真菌偶氮环酰胺
CN104987330B (zh) 2011-02-01 2019-04-05 拜耳知识产权有限责任公司 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物
WO2012107475A1 (en) 2011-02-10 2012-08-16 Syngenta Participations Ag Microbiocidal pyrazole derivatives
WO2012107477A1 (en) 2011-02-10 2012-08-16 Syngenta Participations Ag Microbiocidal pyrazole derivatives
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
DE102011052984A1 (de) 2011-08-25 2013-02-28 Paul Hettich Gmbh & Co. Kg Vorrichtung zur Koppelung eines Schubkastens mit einer Laufschiene einer Auszugsführung
WO2013037768A1 (de) 2011-09-15 2013-03-21 Bayer Intellectual Property Gmbh Piperidinpyrazole als fungizide
WO2013056911A1 (en) 2011-10-18 2013-04-25 Syngenta Participations Ag Microbiocidal pyrazole derivatives
CN103889982A (zh) 2011-10-18 2014-06-25 先正达参股股份有限公司 杀微生物的吡唑衍生物
US8642774B2 (en) 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US8889677B2 (en) 2012-01-17 2014-11-18 Boehringer Ingellheim International GmbH Substituted triazoles useful as mGlu5 receptor modulators
NZ627560A (en) 2012-01-25 2016-08-26 Novartis Ag Heterocyclic piperazine compounds and methods for their use
ES2632237T3 (es) 2012-02-02 2017-09-12 Idorsia Pharmaceuticals Ltd Compuestos de 4-(benzoimidazol-2-il)-tiazol y derivados aza relacionados
EP2820015A1 (en) 2012-03-02 2015-01-07 Syngenta Participations AG Microbiocidal pyrazole derivatives
IN2012DE00620A (es) 2012-03-02 2015-08-21 Syngenta Participations Ag
TWI570120B (zh) 2012-06-04 2017-02-11 艾克泰聯製藥有限公司 苯并咪唑脯胺酸衍生物
US10035790B2 (en) 2012-10-19 2018-07-31 Exelixis, Inc. RORγ modulators
WO2014075874A1 (en) 2012-11-13 2014-05-22 Syngenta Participations Ag Microbiocidal pyrazole derivatives
WO2014075873A1 (en) 2012-11-13 2014-05-22 Syngenta Participations Ag Microbiocidal pyrazole derivatives
KR20150093240A (ko) 2012-12-11 2015-08-17 다케다 야쿠힌 고교 가부시키가이샤 헤테로시클릭 화합물
ES2672736T3 (es) 2013-06-24 2018-06-15 Bayer Cropscience Aktiengesellschaft Derivados de ácido piperidincarboxílico como fungicidas
MX363432B (es) 2013-07-22 2019-03-22 Idorsia Pharmaceuticals Ltd Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona.
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
NZ734542A (en) 2015-01-15 2023-02-24 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators

Also Published As

Publication number Publication date
AR096984A1 (es) 2016-02-10
IL243650A0 (en) 2016-02-29
PL3024832T3 (pl) 2018-10-31
BR112016001238B1 (pt) 2022-10-11
PH12016500134B1 (en) 2016-04-18
KR20160033218A (ko) 2016-03-25
BR112016001238A8 (pt) 2017-12-26
JP2016525137A (ja) 2016-08-22
CN105658649B (zh) 2019-03-22
MX363432B (es) 2019-03-22
EA201600123A1 (ru) 2016-07-29
PH12016500134A1 (en) 2016-04-18
SG11201600504TA (en) 2016-02-26
CA2916338C (en) 2021-07-06
TWI630205B (zh) 2018-07-21
MA38857A1 (fr) 2018-03-30
CL2016000152A1 (es) 2016-09-02
MA38857B1 (fr) 2018-10-31
EP3024832A1 (en) 2016-06-01
TW201536778A (zh) 2015-10-01
SA516370398B1 (ar) 2017-12-14
TR201807959T4 (tr) 2018-06-21
WO2015011099A1 (en) 2015-01-29
ES2671323T3 (es) 2018-06-06
US20160176862A1 (en) 2016-06-23
AU2014295123A1 (en) 2016-03-10
BR112016001238A2 (pt) 2017-12-12
AU2014295123B2 (en) 2018-08-02
US10259807B2 (en) 2019-04-16
CA2916338A1 (en) 2015-01-29
CN105658649A (zh) 2016-06-08
EA030067B1 (ru) 2018-06-29
KR102295416B1 (ko) 2021-08-30
JP6330040B2 (ja) 2018-05-23
EP3024832B1 (en) 2018-03-28

Similar Documents

Publication Publication Date Title
PH12019500188A1 (en) Piperidine cxcr7 receptor modulators
PH12014502540B1 (en) Benzimidazole-proline derivatives
MY167791A (en) 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives as orexin receptor antagonists
JO3275B1 (ar) مشتقات بيرول جديدة وطريقة لتحضيرها وتركيبات صيدلانية التي تحتوي عليها
JO3160B1 (ar) مشتقات الفوسفات الجديدة, طريقة تحضيرها والتركيبات الدوائية التي تحتوي عليها
MX2016012451A (es) Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina.
GB201209587D0 (en) Therapeutic compounds
PH12014501540A1 (en) 4-(benzoimidazol-2-yl) - thiazole compounds and related aza derivatives
PH12017501280A1 (en) Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
TN2016000003A1 (en) New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
MX364610B (es) Derivados de 1- [m-carboxamido (hetero) aril-metil]-heterociclil-c arboxamida.
PH12018500378B1 (en) Novel annelated phenoxyacetamides
PH12015502632A1 (en) Cxcr7 receptor modulators
PH12016500134B1 (en) 1-(piperazin-1-yl) -2- ([1,2,4] triazol -1- yl) - ethanone derivatives
MX2017009292A (es) Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3.
MX2014014308A (es) Pirrolidino heterociclos.
UA112586C2 (uk) Похідні бензімідазолпроліну