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MX2015011507A - Tioesterasas y celulas para producir aceites diseñados. - Google Patents

Tioesterasas y celulas para producir aceites diseñados.

Info

Publication number
MX2015011507A
MX2015011507A MX2015011507A MX2015011507A MX2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A
Authority
MX
Mexico
Prior art keywords
genes
cells
thioesterases
production
fatty acid
Prior art date
Application number
MX2015011507A
Other languages
English (en)
Inventor
Scott Franklin
George N Rudenko
Jason Casolari
Original Assignee
Solazyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/837,996 external-priority patent/US9290749B2/en
Application filed by Solazyme Inc filed Critical Solazyme Inc
Publication of MX2015011507A publication Critical patent/MX2015011507A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La invención presenta genes de tioesterasa acil-ACP de plantas de la clase FatB, y proteínas codificadas por estos genes. Los genes son útiles para la construcción de células huésped recombinantes que tienen perfiles de ácidos grasos alterados. Se divulgan células huésped de microalgas oleaginosas con los nuevos genes o genes FatB previamente identificados. Las células de microalgas producen triglicéridos con perfiles de ácidos grasos útiles.
MX2015011507A 2013-03-15 2014-03-13 Tioesterasas y celulas para producir aceites diseñados. MX2015011507A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361791861P 2013-03-15 2013-03-15
US13/837,996 US9290749B2 (en) 2013-03-15 2013-03-15 Thioesterases and cells for production of tailored oils
US201361917217P 2013-12-17 2013-12-17
PCT/US2014/026644 WO2014151904A1 (en) 2013-03-15 2014-03-13 Thioesterases and cells for production of tailored oils

Publications (1)

Publication Number Publication Date
MX2015011507A true MX2015011507A (es) 2016-04-07

Family

ID=51581068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011507A MX2015011507A (es) 2013-03-15 2014-03-13 Tioesterasas y celulas para producir aceites diseñados.

Country Status (9)

Country Link
EP (1) EP2971024A4 (es)
JP (1) JP2016518112A (es)
KR (1) KR20150128770A (es)
CN (1) CN105143458A (es)
AU (2) AU2014236763B2 (es)
BR (1) BR112015023192A8 (es)
CA (1) CA2904395A1 (es)
MX (1) MX2015011507A (es)
WO (1) WO2014151904A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
BR112017001404A2 (pt) * 2014-07-24 2017-11-21 Terravia Holdings Inc tioesterases variantes e métodos de utilização
EP3194582A2 (en) * 2014-09-18 2017-07-26 TerraVia Holdings, Inc. Acyl-acp thioesterases and mutants thereof
US20180142218A1 (en) 2016-10-05 2018-05-24 Terravia Holdings, Inc. Novel acyltransferases, variant thioesterases, and uses thereof
US11339384B2 (en) * 2017-04-03 2022-05-24 Genomatica, Inc. Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives
EP4090735A1 (en) 2020-01-16 2022-11-23 Corbion Biotech, Inc. Beta-ketoacyl-acp synthase iv variants

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298421A (en) 1990-04-26 1994-03-29 Calgene, Inc. Plant medium-chain-preferring acyl-ACP thioesterases and related methods
US5344771A (en) 1990-04-26 1994-09-06 Calgene, Inc. Plant thiosterases
US5512482A (en) 1990-04-26 1996-04-30 Calgene, Inc. Plant thioesterases
US5455167A (en) 1991-05-21 1995-10-03 Calgene Inc. Medium-chain thioesterases in plants
US5639790A (en) 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
US5654495A (en) 1992-10-30 1997-08-05 Calgene, Inc. Production of myristate in plant cells
US5850022A (en) 1992-10-30 1998-12-15 Calgene, Inc. Production of myristate in plant cells
AU688377B2 (en) * 1993-09-03 1998-03-12 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Medium chain-specific thioesterases
CA2176137A1 (en) 1993-11-10 1995-05-18 Alois Toni Voelker Plant acyl acp thioesterase sequences
US5807893A (en) 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
MX2009012850A (es) 2007-06-01 2010-02-15 Solazyme Inc Produccion de aceite en microorganismos.
JP5677839B2 (ja) * 2007-07-09 2015-02-25 バイエル・クロップサイエンス・エヌ・ヴェーＢａｙｅｒ Ｃｒｏｐｓｃｉｅｎｃｅ Ｎ．Ｖ． 突然変異脂肪酸アシル−ａｃｐチオエステラーゼ対立遺伝子を含むアブラナ属植物
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
AU2009259433A1 (en) * 2008-06-20 2009-12-23 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
US7935515B2 (en) 2008-11-28 2011-05-03 Solazyme, Inc. Recombinant microalgae cells producing novel oils
BRPI1014952A2 (pt) * 2009-04-10 2019-09-24 Ls9 Inc "composição produzida por um microrganismo e composição de biocombustível."
ES2718489T3 (es) 2010-05-28 2019-07-02 Corbion Biotech Inc Método para producir aceites a partir de Prototheca
JP6071904B2 (ja) * 2011-02-02 2017-02-01 テラヴィア ホールディングス， インコーポレイテッド 組み換え油産生微生物から生成される用途に応じた油
US8951762B2 (en) * 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
CN102586350A (zh) 2012-01-09 2012-07-18 北京化工大学 一种c8:0/c10:0/c12:0/c14:0中链脂肪酸及其乙酯的生产方法
SG11201406711TA (en) 2012-04-18 2014-11-27 Solazyme Inc Tailored oils

Also Published As

Publication number Publication date
KR20150128770A (ko) 2015-11-18
AU2014236763B2 (en) 2018-08-23
AU2018267601A1 (en) 2018-12-06
CA2904395A1 (en) 2014-09-25
WO2014151904A1 (en) 2014-09-25
EP2971024A1 (en) 2016-01-20
AU2014236763A1 (en) 2015-10-01
CN105143458A (zh) 2015-12-09
BR112015023192A2 (pt) 2017-11-21
EP2971024A4 (en) 2016-11-16
JP2016518112A (ja) 2016-06-23
BR112015023192A8 (pt) 2018-01-02

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