MX2014012285A - Composicion farmaceutica que contiene un inhibidor de serina proteasa para tratar o prevenir infeccion por el virus de la influenza. - Google Patents
Composicion farmaceutica que contiene un inhibidor de serina proteasa para tratar o prevenir infeccion por el virus de la influenza.Info
- Publication number
- MX2014012285A MX2014012285A MX2014012285A MX2014012285A MX2014012285A MX 2014012285 A MX2014012285 A MX 2014012285A MX 2014012285 A MX2014012285 A MX 2014012285A MX 2014012285 A MX2014012285 A MX 2014012285A MX 2014012285 A MX2014012285 A MX 2014012285A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- treating
- inhibitor
- virus infection
- influenza virus
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 241000712461 unidentified influenza virus Species 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 229940122055 Serine protease inhibitor Drugs 0.000 title 1
- 101710102218 Serine protease inhibitor Proteins 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 4
- 101710154606 Hemagglutinin Proteins 0.000 abstract 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 2
- 101710176177 Protein A56 Proteins 0.000 abstract 2
- 239000000185 hemagglutinin Substances 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención provee una composición para tratar o prevenir la infección por el virus de la influenza. La presente invención comprende la administración a un sujeto que así lo requiere de una composición farmacéutica que comprende un inhibidor de serina proteasa transmembrana (TTSP) tipo II. El inhibidor de TTSP funciona preferiblemente inhibiendo la escisión proteolítica de hemaglutinina (HA0) de la influenza en la subunidades funcionales HA1 y HA2. En ciertas modalidades, el inhibidor de TTSP es un inhibidor de proteasa serina S1 miembro 2 transmembrana (TMPRSS2), tal como un anticuerpo anti-TMPRSS2 o un fragmento de enlazamiento al antígeno del mismo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624519P | 2012-04-16 | 2012-04-16 | |
| US201361759469P | 2013-02-01 | 2013-02-01 | |
| PCT/US2013/036522 WO2013158516A1 (en) | 2012-04-16 | 2013-04-15 | Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014012285A true MX2014012285A (es) | 2015-04-13 |
Family
ID=48184523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012285A MX2014012285A (es) | 2012-04-16 | 2013-04-15 | Composicion farmaceutica que contiene un inhibidor de serina proteasa para tratar o prevenir infeccion por el virus de la influenza. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9498529B2 (es) |
| EP (2) | EP2838558A1 (es) |
| JP (2) | JP6446355B2 (es) |
| KR (1) | KR20150008383A (es) |
| CN (1) | CN104244978A (es) |
| AU (2) | AU2013249577A1 (es) |
| BR (1) | BR112014025339A8 (es) |
| CA (2) | CA2869010A1 (es) |
| HK (1) | HK1202817A1 (es) |
| MX (1) | MX2014012285A (es) |
| NZ (1) | NZ631105A (es) |
| SG (1) | SG11201405163RA (es) |
| WO (1) | WO2013158516A1 (es) |
| ZA (1) | ZA201406194B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2886958T3 (es) * | 2016-02-29 | 2021-12-21 | Regeneron Pharma | Roedores que tienen un gen TMPRSS humanizado |
| KR101693243B1 (ko) * | 2016-06-15 | 2017-01-05 | 재단법인 한국파스퇴르연구소 | 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도 |
| CN120290578A (zh) * | 2018-01-26 | 2025-07-11 | 瑞泽恩制药公司 | 抗tmprss2抗体和抗原结合片段 |
| IL294529A (en) * | 2020-02-10 | 2022-09-01 | Regeneron Pharma | Anti-tmprss2 antibodies and antigen-binding fragments |
| WO2021190980A1 (en) | 2020-03-22 | 2021-09-30 | Quadrucept Bio Limited | Multimers for viral strain evolution |
| WO2021195119A1 (en) * | 2020-03-24 | 2021-09-30 | Corcept Therapeutics Incorporated | Methods of reducing the risk of, severity of, and treating coronavirus infections |
| EP3964207A1 (en) | 2020-09-02 | 2022-03-09 | Christian-Albrechts-Universität zu Kiel | Antiviral pharmaceutical composition for topical administration |
| WO2022184659A1 (en) | 2021-03-01 | 2022-09-09 | Quadrucept Bio Limited | Antibody domains & multimers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166194A (en) * | 1998-06-29 | 2000-12-26 | Myriad Genetics, Inc. | TMPRSS2 is a tumor suppressor |
| WO2004097358A2 (en) | 2003-05-02 | 2004-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 2 (tmprss2) |
| KR101387781B1 (ko) * | 2005-01-07 | 2014-04-21 | 렉시컨 파마슈티컬스 인코퍼레이티드 | 앤지오포이에틴-유사 단백질 4 (ａｎｇｐｔｌ４) 에 대한단일클론 항체 |
| US20070191322A1 (en) | 2006-02-01 | 2007-08-16 | Savage Paul B | Cationic Steroid Microbial Compositions and Methods of Use |
| JP2008247864A (ja) * | 2007-03-30 | 2008-10-16 | Univ Of Tokushima | モザイクセリンプロテアーゼ、ｍｓｐとその用途 |
| JP2008308438A (ja) * | 2007-06-14 | 2008-12-25 | Mitsubishi Tanabe Pharma Corp | 新規なインフルエンザ治療および／または予防薬 |
| US20120115995A1 (en) | 2009-06-22 | 2012-05-10 | Klaus Lederer | Automotive interior article with reduced smell |
| PT3702374T (pt) * | 2012-02-15 | 2022-06-23 | Cydex Pharmaceuticals Inc | Processo de fabrico para derivados de ciclodextrina |
-
2013
- 2013-04-15 MX MX2014012285A patent/MX2014012285A/es active IP Right Grant
- 2013-04-15 EP EP13718744.9A patent/EP2838558A1/en not_active Ceased
- 2013-04-15 JP JP2015507076A patent/JP6446355B2/ja active Active
- 2013-04-15 US US13/862,497 patent/US9498529B2/en active Active
- 2013-04-15 SG SG11201405163RA patent/SG11201405163RA/en unknown
- 2013-04-15 HK HK15103529.7A patent/HK1202817A1/xx unknown
- 2013-04-15 WO PCT/US2013/036522 patent/WO2013158516A1/en not_active Ceased
- 2013-04-15 NZ NZ631105A patent/NZ631105A/en unknown
- 2013-04-15 EP EP19155349.4A patent/EP3536342A1/en not_active Withdrawn
- 2013-04-15 KR KR1020147028956A patent/KR20150008383A/ko not_active Ceased
- 2013-04-15 CA CA2869010A patent/CA2869010A1/en not_active Withdrawn
- 2013-04-15 BR BR112014025339A patent/BR112014025339A8/pt not_active Application Discontinuation
- 2013-04-15 CN CN201380020133.9A patent/CN104244978A/zh active Pending
- 2013-04-15 CA CA3219083A patent/CA3219083A1/en active Pending
- 2013-04-15 AU AU2013249577A patent/AU2013249577A1/en not_active Abandoned
-
2014
- 2014-08-22 ZA ZA2014/06194A patent/ZA201406194B/en unknown
-
2017
- 2017-10-20 JP JP2017203146A patent/JP2018048169A/ja not_active Withdrawn
-
2018
- 2018-01-12 AU AU2018200265A patent/AU2018200265B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104244978A (zh) | 2014-12-24 |
| HK1202817A1 (en) | 2015-10-09 |
| KR20150008383A (ko) | 2015-01-22 |
| EP3536342A1 (en) | 2019-09-11 |
| CA2869010A1 (en) | 2013-10-24 |
| BR112014025339A8 (pt) | 2018-01-16 |
| CA3219083A1 (en) | 2013-10-24 |
| JP2015516975A (ja) | 2015-06-18 |
| EP2838558A1 (en) | 2015-02-25 |
| US20130273070A1 (en) | 2013-10-17 |
| AU2013249577A1 (en) | 2014-10-02 |
| JP2018048169A (ja) | 2018-03-29 |
| NZ631105A (en) | 2016-09-30 |
| BR112014025339A2 (pt) | 2013-10-24 |
| WO2013158516A1 (en) | 2013-10-24 |
| JP6446355B2 (ja) | 2018-12-26 |
| AU2018200265A1 (en) | 2018-02-01 |
| SG11201405163RA (en) | 2014-09-26 |
| AU2018200265B2 (en) | 2019-07-18 |
| ZA201406194B (en) | 2016-08-31 |
| US9498529B2 (en) | 2016-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |