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MX2014004521A - Anticuerpo estable de union a antigenos multiples. - Google Patents

Anticuerpo estable de union a antigenos multiples.

Info

Publication number
MX2014004521A
MX2014004521A MX2014004521A MX2014004521A MX2014004521A MX 2014004521 A MX2014004521 A MX 2014004521A MX 2014004521 A MX2014004521 A MX 2014004521A MX 2014004521 A MX2014004521 A MX 2014004521A MX 2014004521 A MX2014004521 A MX 2014004521A
Authority
MX
Mexico
Prior art keywords
chain variable
antibodies
binding antibody
domains
multiple antigen
Prior art date
Application number
MX2014004521A
Other languages
English (en)
Inventor
Leonardo Borras
Astrid C Riegler
Roberto Sommavilla
Original Assignee
Esbatech A Novartis Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech A Novartis Co Llc filed Critical Esbatech A Novartis Co Llc
Publication of MX2014004521A publication Critical patent/MX2014004521A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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Abstract

La invención proporciona anticuerpos que se unen a antígenos múltiples, dichos anticuerpos tienen al menos dos dominios variables de cadena ligera de anticuerpo y dos dominios variables de cadena pesada de anticuerpo, donde cada dominio variable de cadena ligera está unido a un dominio variable de cadena pesada para formar una construcción VH/VL, y donde al menos uno de los dominios VH comprende un aminoácido particular en la posición AHo 12, 103 y/o 144, y al menos uno de los dominios VL comprende un aminoácido particular en la posición AHo 47 y/o 50. También se describen moléculas de ácido nucleico, vectores y células hospedadoras para la expresión de anticuerpos recombinantes de la invención, métodos para aislarlos, y el uso de dichos anticuerpos en la medicina.
MX2014004521A 2011-10-20 2012-10-19 Anticuerpo estable de union a antigenos multiples. MX2014004521A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20
PCT/EP2012/004404 WO2013056851A2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

Publications (1)

Publication Number Publication Date
MX2014004521A true MX2014004521A (es) 2014-05-28

Family

ID=47115743

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004521A MX2014004521A (es) 2011-10-20 2012-10-19 Anticuerpo estable de union a antigenos multiples.

Country Status (15)

Country Link
US (2) US20130101586A1 (es)
EP (2) EP2768855B1 (es)
JP (3) JP2014533239A (es)
KR (1) KR20140082700A (es)
CN (2) CN109608543A (es)
AR (1) AR088403A1 (es)
AU (1) AU2012325232B2 (es)
BR (1) BR112014009030A2 (es)
CA (1) CA2850572A1 (es)
ES (1) ES2687245T3 (es)
MX (1) MX2014004521A (es)
RU (2) RU2018112861A (es)
TW (1) TWI577696B (es)
UY (1) UY34404A (es)
WO (1) WO2013056851A2 (es)

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US20200048336A1 (en) 2020-02-13
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AU2012325232B2 (en) 2017-08-31
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