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MX2014002285A - Inhibidores de la replicacion del vih. - Google Patents

Inhibidores de la replicacion del vih.

Info

Publication number
MX2014002285A
MX2014002285A MX2014002285A MX2014002285A MX2014002285A MX 2014002285 A MX2014002285 A MX 2014002285A MX 2014002285 A MX2014002285 A MX 2014002285A MX 2014002285 A MX2014002285 A MX 2014002285A MX 2014002285 A MX2014002285 A MX 2014002285A
Authority
MX
Mexico
Prior art keywords
substituted
hiv replication
replication inhibitors
group
unsubstituted aryl
Prior art date
Application number
MX2014002285A
Other languages
English (en)
Inventor
D P Cosford Nicholas
PAGANO Nicholas
TERIETE Peter
L Heil Marintha
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of MX2014002285A publication Critical patent/MX2014002285A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de la Fórmula (I), en donde B se selecciona del grupo que consiste de arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido; Y es un residuo enlazador seleccionado del grupo que consiste de una unión directa. R, R1, R2 y R3 se seleccionan cada uno individualmente del grupo que consiste de arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido o heterociclo.
MX2014002285A 2011-08-26 2012-08-27 Inhibidores de la replicacion del vih. MX2014002285A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161527895P 2011-08-26 2011-08-26
PCT/US2012/052482 WO2013033003A1 (en) 2011-08-26 2012-08-27 Hiv replication inhibitors

Publications (1)

Publication Number Publication Date
MX2014002285A true MX2014002285A (es) 2017-01-06

Family

ID=47756783

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002285A MX2014002285A (es) 2011-08-26 2012-08-27 Inhibidores de la replicacion del vih.

Country Status (11)

Country Link
US (1) US9120787B2 (es)
EP (1) EP2748150B1 (es)
JP (1) JP5969031B2 (es)
CN (1) CN103827094B (es)
AU (1) AU2012300274B2 (es)
BR (1) BR112014003989A2 (es)
CA (1) CA2844119A1 (es)
ES (1) ES2617332T3 (es)
MX (1) MX2014002285A (es)
WO (1) WO2013033003A1 (es)
ZA (1) ZA201401330B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573470A (zh) 2009-11-02 2012-07-11 宋嘉盛 用于介入治疗和根除癌症的ite
US10632106B2 (en) 2009-11-02 2020-04-28 Ariagen, Inc. Methods of cancer treatment with 2-(1′H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester
ES2848065T3 (es) 2014-09-12 2021-08-05 Ariagen Inc Síntesis eficiente y escalable de éster metílico del ácido 2-(1¿H-indol-3¿-carbonil)-tiazol-4-carboxílico y sus análogos estructurales
CN108239083B (zh) 2016-12-26 2021-08-17 阿里根公司 芳香烃受体调节剂
WO2019099977A2 (en) 2017-11-20 2019-05-23 Ariagen, Inc. Indole compounds and their use
AU2020258394A1 (en) 2019-04-15 2021-10-28 Ariagen, Inc. Chiral indole compounds and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900214B2 (en) 2001-03-29 2005-05-31 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
AR048962A1 (es) 2004-05-17 2006-06-14 Tibotec Pharm Ltd Combinaciones de 1- fenil-1,5 - dihidro - pirido - (3,2-b) indol -2- onas sustituidas y otros inhibidores de vih
WO2009020457A2 (en) * 2006-06-30 2009-02-12 Smithkline Beecham Corporation Chemical compounds
MY150285A (en) 2007-12-20 2013-12-31 Bayer Ip Gmbh 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds

Also Published As

Publication number Publication date
US20140235582A1 (en) 2014-08-21
BR112014003989A2 (pt) 2017-06-13
EP2748150B1 (en) 2016-11-30
WO2013033003A1 (en) 2013-03-07
US9120787B2 (en) 2015-09-01
CN103827094B (zh) 2017-09-26
EP2748150A1 (en) 2014-07-02
NZ622558A (en) 2016-09-30
ZA201401330B (en) 2019-08-28
ES2617332T3 (es) 2017-06-16
CA2844119A1 (en) 2013-03-07
JP2014525416A (ja) 2014-09-29
CN103827094A (zh) 2014-05-28
AU2012300274B2 (en) 2017-06-29
EP2748150A4 (en) 2015-01-07
AU2012300274A1 (en) 2014-03-06
JP5969031B2 (ja) 2016-08-10

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