[go: up one dir, main page]

MX2014001920A - Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma. - Google Patents

Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma.

Info

Publication number
MX2014001920A
MX2014001920A MX2014001920A MX2014001920A MX2014001920A MX 2014001920 A MX2014001920 A MX 2014001920A MX 2014001920 A MX2014001920 A MX 2014001920A MX 2014001920 A MX2014001920 A MX 2014001920A MX 2014001920 A MX2014001920 A MX 2014001920A
Authority
MX
Mexico
Prior art keywords
apolipoprotein
fusion protein
lipid particle
particle containing
shortened tetranectin
Prior art date
Application number
MX2014001920A
Other languages
English (en)
Inventor
Roberto Falkenstein
Martin Bader
Christian Schantz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014001920A publication Critical patent/MX2014001920A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Aquí se describe una proteína de fusión tetranectina-apolipoproteí na A-I acortada y una partícula lipídica que comprende la proteína de fusión tetranectina-apolipoproteína A-I acortada así como la utilización de las mismas.
MX2014001920A 2011-08-25 2012-08-22 Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma. MX2014001920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11178746 2011-08-25
PCT/EP2012/066301 WO2013026860A1 (en) 2011-08-25 2012-08-22 Shortened tetranectin-apolipoprotein a-i fusion protein, a lipid particle containing it, and uses thereof

Publications (1)

Publication Number Publication Date
MX2014001920A true MX2014001920A (es) 2014-04-14

Family

ID=46704687

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001920A MX2014001920A (es) 2011-08-25 2012-08-22 Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma.

Country Status (11)

Country Link
US (2) US8791063B2 (es)
EP (1) EP2748191A1 (es)
JP (2) JP6207507B2 (es)
KR (1) KR20140054115A (es)
CN (1) CN103703023A (es)
AR (1) AR087640A1 (es)
BR (1) BR112013033562A2 (es)
CA (1) CA2838070A1 (es)
MX (1) MX2014001920A (es)
RU (1) RU2014108240A (es)
WO (1) WO2013026860A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11124558B2 (en) * 2017-06-02 2021-09-21 The Feinstein Institutes For Medical Research Use of tetranectin and peptide agonists to treat inflammatory diseases

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608347A (en) 1982-04-15 1986-08-26 Bernstam Victor A Compositions, uses and methods creating reverse micelles for the clarification of biological fluids to obtain undistorted assay of analytes following clarification
WO1992005192A1 (en) 1990-09-18 1992-04-02 Biotech Australia Pty. Limited T-cell epitopes
SE9103701D0 (sv) 1991-12-13 1991-12-13 Kabi Pharmacia Ab Apolipoprotein
ATE282092T1 (de) 1997-06-11 2004-11-15 Borean Pharma As Trimerisierendes modul
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
EP0972838B1 (en) 1998-07-15 2004-09-15 Roche Diagnostics GmbH Escherichia coli host/vector system based on antibiotic-free selection by complementation of an auxotrophy
US6291245B1 (en) 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
CA2406039A1 (en) 2000-04-14 2001-10-25 Hyseq, Inc. Materials and methods relating to lipid metabolism
EP2343317A1 (en) 2000-11-10 2011-07-13 F. Hoffmann-La Roche Ltd. Apolipoprotein analogues
JP2006502976A (ja) 2002-05-17 2006-01-26 エスペリオン セラピューティクス,インコーポレイテッド 虚血再潅流を治療する方法および組成物
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
WO2003096983A2 (en) 2002-05-17 2003-11-27 Esperion Therapeutics, Inc. Method of treating dyslipidemic disorders
WO2004005335A2 (en) * 2002-07-05 2004-01-15 Borean Pharma A/S Multimerised growth hormone fusion proteins
CA2443365C (en) 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
US20040180445A1 (en) 2003-03-12 2004-09-16 Domanico Michael J. Methods and compositions for purification of nucleic acid from a host cell
EP1486571B1 (en) 2003-06-12 2005-12-14 F. Hoffmann-La Roche Ag Method for the recombinant production of polypeptides
PE20050438A1 (es) 2003-10-20 2005-06-14 Esperion Therapeutics Inc Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos
WO2005041886A2 (en) 2003-10-31 2005-05-12 Metaphore Pharmaceuticals, Inc. Methods for generating or increasing revenues related to pain inhibitor commerce
US7608278B2 (en) 2003-12-30 2009-10-27 Wyeth Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
WO2005084642A1 (en) 2004-01-28 2005-09-15 Biodelivery Sciences International, Inc. Apoprotein cochleate compositions
US20090143276A1 (en) * 2007-10-08 2009-06-04 Anaphore, Inc. Trimeric IL-1Ra
US20100028995A1 (en) 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
KR100560102B1 (ko) 2004-06-25 2006-03-13 한국생명공학연구원 프로아포리포단백질 a-ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제
JP2008514240A (ja) 2004-10-01 2008-05-08 インヴィトロジェン コーポレーション 生体分子のインビトロ合成用の供給バッファー、系、及び方法
WO2006047614A2 (en) 2004-10-26 2006-05-04 Invitrogen Corporation Compositions and methods for analyzing biomolecules using mass spectroscopy
US20060160721A1 (en) 2004-12-22 2006-07-20 Baylor College Of Medicine Method of plasma lipidation to prevent, inhibit and/or reverse atherosclerosis
US8206750B2 (en) * 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
WO2006125304A1 (en) 2005-05-25 2006-11-30 Liponex, Inc. Pharmaceutical compositions for treating or preventing coronary artery disease
US20070254832A1 (en) 2006-02-17 2007-11-01 Pressler Milton L Methods for the treatment of macular degeneration and related eye conditions
CA2653840A1 (en) 2006-06-01 2007-12-06 Institut De Cardiologie De Montreal Use of a peptide/phospholipid complex acting as a reverse lipid transport agonist for treatment of valvular stenosis
US20080064071A1 (en) 2006-07-25 2008-03-13 Hogrefe Holly H Zwitterionic detergents for the storage and use of DNA polymerases
WO2008017906A1 (en) 2006-08-10 2008-02-14 Plantechno S.R.L. In-plant production of dimeric and/or oligomeric (comprising three or more units) forms of human apo a-1 protein muteins
WO2008094905A2 (en) 2007-01-29 2008-08-07 Lipid Sciences, Inc. Encapsulated hdl mimetic peptides
EP2118129A4 (en) 2007-03-01 2010-04-28 Life Technologies Corp ISOLATED PHOSPHOLIPID PROTEIN PARTICLES
FR2915490B1 (fr) 2007-04-26 2011-10-28 Univ Joseph Fourier Grenoble I Formation de proteoliposomes contenant des proteines membranaires a l'aide d'un systeme de synthese proteique acellulaire
AU2008266753A1 (en) 2007-06-20 2008-12-24 Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. ApoA-1 peptide mimetics
WO2009036460A2 (en) 2007-09-14 2009-03-19 Ambrx, Inc. Modified human apolipoprotein a-i polypeptides and their uses
AU2008310902A1 (en) * 2007-10-08 2009-04-16 Anaphore, Inc. Trimeric IL-1Ra
WO2009097587A2 (en) 2008-01-30 2009-08-06 The Rockefeller University Nanoscale bound bilayers, methods of use and production
EP2288336B8 (en) 2008-04-25 2017-03-22 Northwestern University Nanostructures suitable for sequestering cholesterol
MX2010013759A (es) * 2008-06-13 2011-05-25 Proyecto Biomedicina Cima Sl Conjugados para la administracion de compuestos biologicamente activos.
WO2010083611A1 (en) 2009-01-23 2010-07-29 Institut De Cardiologie De Montreal Method for the prevention and treatment of diastolic dysfunction employing an apolipoproteina1 (apoa1) mimetic peptide/phospholipid complex
US20110086770A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Combinatorial Libraries Based on C-type Lectin-like Domain
CA2807431A1 (en) 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Prokaryotic expression construct
US20120190609A1 (en) 2010-08-30 2012-07-26 Martin Bader Method for producing a lipid particle, the lipid particle itself and its use
RU2013112562A (ru) 2010-08-30 2014-10-10 Ф. Хоффманн-Ля Рош Аг Тетранектин-аполипопротеин а-i, содержащие его липидные частицы и его применение
EP2611900B1 (en) 2010-08-30 2015-11-25 F.Hoffmann-La Roche Ag Alkaline feed
US20130053551A1 (en) 2011-08-25 2013-02-28 Hoffman-La Roche. Inc. Cation and anion exchange chromatography method
HK1198480A1 (en) 2012-02-29 2015-05-08 霍夫曼-拉罗奇有限公司 Method for reduction of 1->2 reading frame shifts
CN104144939A (zh) 2012-02-29 2014-11-12 霍夫曼-拉罗奇有限公司 柱上酶切割
JP2015508662A (ja) 2012-02-29 2015-03-23 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 1→3リーディングフレームシフトを減少させるための方法

Also Published As

Publication number Publication date
RU2014108240A (ru) 2015-09-27
US8791063B2 (en) 2014-07-29
US20130231273A1 (en) 2013-09-05
CN103703023A (zh) 2014-04-02
US9139640B2 (en) 2015-09-22
KR20140054115A (ko) 2014-05-08
CA2838070A1 (en) 2013-02-28
US20150011459A1 (en) 2015-01-08
AR087640A1 (es) 2014-04-09
JP6207507B2 (ja) 2017-10-04
BR112013033562A2 (pt) 2017-02-14
WO2013026860A1 (en) 2013-02-28
EP2748191A1 (en) 2014-07-02
JP2017171670A (ja) 2017-09-28
JP2014529602A (ja) 2014-11-13

Similar Documents

Publication Publication Date Title
EP4223770A3 (en) Novel fusion molecules and uses thereof
CA144407S (en) Lighting
MX2019003214A (es) Formulaciones de proteina de inmunoglobulina del dominio variable dual estable.
CA145239S (en) Teapot
MX368288B (es) Una combinación de anticuerpos anti-cd38 y melfalán para usarse en el tratamiento de mieloma múltiple.
MY168166A (en) Polymer and Composition Including Same, and Adhesive Composition
EP2698386B8 (en) Fusion protein
MY157836A (en) Laminate
KR20180085063A (ko) 신규 단백질 소재
CA141191S (en) Packaging
EP2521143B8 (de) Magnetisch wirksamer Werkstoff
CA141825S (en) Packaging
CA145236S (en) Pitcher
MX2014001920A (es) Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma.
EP2665366A1 (de) Kalorienreduizierte zubereitungen für die herstellung von instant-getränken und deren herstellung
WO2013095994A3 (en) Transparent aqueous fragrance microemulsions
CA141192S (en) Packaging
CA141190S (en) Packaging
AU2012101533A4 (en) The Wheelie Fast
HK1189602A (en) Anticancer fusion protein
AU2011905145A0 (en) Fusion Protein
GB201205549D0 (en) Electrochromism bulb: Theory, Technology & application
CA145333S (en) Flashlight
AU338253S (en) Retail Unloader
AU2011904559A0 (en) Ctshws500/2.7