MX2013015075A - Metodo para fabricar derivados de almidon de hidroxietilo. - Google Patents
Metodo para fabricar derivados de almidon de hidroxietilo.Info
- Publication number
- MX2013015075A MX2013015075A MX2013015075A MX2013015075A MX2013015075A MX 2013015075 A MX2013015075 A MX 2013015075A MX 2013015075 A MX2013015075 A MX 2013015075A MX 2013015075 A MX2013015075 A MX 2013015075A MX 2013015075 A MX2013015075 A MX 2013015075A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxyethyl starch
- temperature
- value
- solution
- starch derivatives
- Prior art date
Links
- 229920001612 Hydroxyethyl starch Polymers 0.000 title abstract 4
- 229940050526 hydroxyethylstarch Drugs 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000019426 modified starch Nutrition 0.000 title 1
- KWMLJOLKUYYJFJ-UHFFFAOYSA-N 2,3,4,5,6,7-Hexahydroxyheptanoic acid Chemical group OCC(O)C(O)C(O)C(O)C(O)C(O)=O KWMLJOLKUYYJFJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 cyanide compound Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/10—Alkyl or cycloalkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se refiere a un método para fabricar un almidón de hidroxietilo modificado que lleva un residuo de ácido heptónico en al menos uno de sus extremos. De acuerdo con la invención, las siguientes etapas se llevan a cabo: a) disolver el almidón de hidroxietilo en agua, b) ajustar el valor de pH a un valor de 8.0 a 10.0, c) agregar un compuesto de cianuro a la solución de almidón de hidroxietilo, calentar la solución a una temperatura de 80 a 99°C y mantenerla a esta temperatura durante un primer periodo de tiempo, y d) ajustar el valor de pH a un valor de 2.0 a 4.0, llevar la solución a una temperatura de 50 a 90°C y mantenerla a esta temperatura durante un segundo periodo de tiempo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170761A EP2537866A1 (en) | 2011-06-21 | 2011-06-21 | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
| PCT/EP2012/061958 WO2012175608A1 (en) | 2011-06-21 | 2012-06-21 | Method for manufacturing hydroxyethyl starch derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013015075A true MX2013015075A (es) | 2014-04-14 |
| MX337682B MX337682B (es) | 2016-03-15 |
Family
ID=44799422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013015075A MX337682B (es) | 2011-06-21 | 2012-06-21 | Metodo para fabricar derivados de almidon de hidroxietilo. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9181353B2 (es) |
| EP (2) | EP2537866A1 (es) |
| JP (2) | JP6370217B2 (es) |
| CN (2) | CN103649128B (es) |
| BR (1) | BR112013032901A2 (es) |
| CA (1) | CA2837784C (es) |
| CY (1) | CY1121976T1 (es) |
| DK (1) | DK2723774T3 (es) |
| ES (1) | ES2733767T3 (es) |
| HK (1) | HK1220218A1 (es) |
| HR (1) | HRP20191173T1 (es) |
| HU (1) | HUE044428T2 (es) |
| LT (1) | LT2723774T (es) |
| MX (1) | MX337682B (es) |
| PL (1) | PL2723774T3 (es) |
| PT (1) | PT2723774T (es) |
| RS (1) | RS59021B1 (es) |
| SI (1) | SI2723774T1 (es) |
| SM (1) | SMT201900430T1 (es) |
| TR (1) | TR201909574T4 (es) |
| TW (1) | TWI564010B (es) |
| WO (1) | WO2012175608A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6616725B2 (ja) * | 2016-03-31 | 2019-12-04 | 日本製紙株式会社 | 塗工紙用澱粉 |
| WO2020144667A1 (en) | 2019-01-10 | 2020-07-16 | Pharmacosmos Holding A/S | Treating iron deficiency in subjects at risk of cardiovascular adverse events and iron for the management of atrial fibrillation |
| CN114286682A (zh) | 2019-02-09 | 2022-04-05 | 法码科思莫斯控股有限公司 | 治疗具有心血管不良事件风险的个体的铁缺乏以及用于治疗心房颤动的铁 |
| MX2024001607A (es) | 2021-08-03 | 2024-02-27 | Pharmacosmos Holding As | Compuestos de complejos de hierro para uso subcutáneo en la terapia de la ferropenia en animales de compañía. |
| CN117547549A (zh) * | 2023-11-09 | 2024-02-13 | 黑龙江八一农垦大学 | 适用于犬arf的腹膜透析液与助清除剂的制备方法 |
| WO2026017897A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639588A (en) * | 1966-10-22 | 1972-02-01 | Fisons Pharmaceuticals Ltd | Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids |
| US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
| GB8902894D0 (en) * | 1989-02-09 | 1989-03-30 | Fisons Plc | Compositions |
| JPH0566372A (ja) * | 1991-09-10 | 1993-03-19 | Fukui Megane Kogyo Kk | 金属製眼鏡フレーム部品の製造方法 |
| JPH0776524A (ja) * | 1993-07-13 | 1995-03-20 | Takeda Chem Ind Ltd | 動物用抗貧血剤 |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DK173138B1 (da) * | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
| JP5178836B2 (ja) * | 2007-08-17 | 2013-04-10 | アクゾ ノーベル ナムローゼ フェンノートシャップ | グルタミン酸ｎ，ｎ−二酢酸のアルカリ金属塩、そのような塩の調製プロセス及びその使用 |
| TWI469965B (zh) * | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| JP5397991B2 (ja) * | 2009-04-01 | 2014-01-22 | 学校法人東京農業大学 | 乳酸菌を用いたビタミンｂ１２の定量方法 |
-
2011
- 2011-06-21 EP EP11170761A patent/EP2537866A1/en not_active Withdrawn
-
2012
- 2012-06-21 TW TW101122208A patent/TWI564010B/zh active
- 2012-06-21 HU HUE12737229 patent/HUE044428T2/hu unknown
- 2012-06-21 US US14/127,766 patent/US9181353B2/en active Active
- 2012-06-21 LT LTEP12737229.0T patent/LT2723774T/lt unknown
- 2012-06-21 TR TR2019/09574T patent/TR201909574T4/en unknown
- 2012-06-21 EP EP12737229.0A patent/EP2723774B1/en active Active
- 2012-06-21 CN CN201280029882.3A patent/CN103649128B/zh active Active
- 2012-06-21 CA CA2837784A patent/CA2837784C/en active Active
- 2012-06-21 SI SI201231627T patent/SI2723774T1/sl unknown
- 2012-06-21 MX MX2013015075A patent/MX337682B/es active IP Right Grant
- 2012-06-21 DK DK12737229.0T patent/DK2723774T3/da active
- 2012-06-21 PL PL12737229T patent/PL2723774T3/pl unknown
- 2012-06-21 JP JP2014516345A patent/JP6370217B2/ja active Active
- 2012-06-21 SM SM20190430T patent/SMT201900430T1/it unknown
- 2012-06-21 WO PCT/EP2012/061958 patent/WO2012175608A1/en not_active Ceased
- 2012-06-21 ES ES12737229T patent/ES2733767T3/es active Active
- 2012-06-21 PT PT12737229T patent/PT2723774T/pt unknown
- 2012-06-21 RS RS20190850A patent/RS59021B1/sr unknown
- 2012-06-21 HR HRP20191173TT patent/HRP20191173T1/hr unknown
- 2012-06-21 CN CN201510909616.5A patent/CN105348401A/zh active Pending
- 2012-06-21 BR BR112013032901A patent/BR112013032901A2/pt not_active Application Discontinuation
-
2015
- 2015-10-26 US US14/922,897 patent/US9631032B2/en active Active
-
2016
- 2016-07-12 HK HK16108112.8A patent/HK1220218A1/zh unknown
-
2018
- 2018-03-27 JP JP2018059264A patent/JP2018100424A/ja active Pending
-
2019
- 2019-07-03 CY CY20191100704T patent/CY1121976T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105348401A (zh) | 2016-02-24 |
| CA2837784A1 (en) | 2012-12-27 |
| US20140128594A1 (en) | 2014-05-08 |
| RS59021B1 (sr) | 2019-08-30 |
| DK2723774T3 (da) | 2019-07-15 |
| TR201909574T4 (en) | 2019-08-21 |
| HRP20191173T1 (hr) | 2019-10-04 |
| CY1121976T1 (el) | 2020-10-14 |
| JP2018100424A (ja) | 2018-06-28 |
| WO2012175608A1 (en) | 2012-12-27 |
| TW201315474A (zh) | 2013-04-16 |
| PT2723774T (pt) | 2019-07-15 |
| EP2723774A1 (en) | 2014-04-30 |
| LT2723774T (lt) | 2019-08-12 |
| CN103649128B (zh) | 2016-02-10 |
| SMT201900430T1 (it) | 2019-09-09 |
| EP2537866A1 (en) | 2012-12-26 |
| PL2723774T3 (pl) | 2019-10-31 |
| HK1220218A1 (zh) | 2017-04-28 |
| JP6370217B2 (ja) | 2018-08-08 |
| HUE044428T2 (hu) | 2019-10-28 |
| SI2723774T1 (sl) | 2019-08-30 |
| ES2733767T3 (es) | 2019-12-02 |
| EP2723774B1 (en) | 2019-04-03 |
| CN103649128A (zh) | 2014-03-19 |
| JP2014520188A (ja) | 2014-08-21 |
| MX337682B (es) | 2016-03-15 |
| TWI564010B (zh) | 2017-01-01 |
| US9181353B2 (en) | 2015-11-10 |
| CA2837784C (en) | 2019-10-15 |
| US9631032B2 (en) | 2017-04-25 |
| BR112013032901A2 (pt) | 2017-01-24 |
| US20160046733A1 (en) | 2016-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |