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MX2013014475A - COMPUESTOS DE ENLACE A ß1-ADRENORECEPTOR HUMANO (ß-AR) Y SU USO EN LA MEDICION DE ANTICUERPOS AUTO-ANTI-ß1-AR. - Google Patents

COMPUESTOS DE ENLACE A ß1-ADRENORECEPTOR HUMANO (ß-AR) Y SU USO EN LA MEDICION DE ANTICUERPOS AUTO-ANTI-ß1-AR.

Info

Publication number
MX2013014475A
MX2013014475A MX2013014475A MX2013014475A MX2013014475A MX 2013014475 A MX2013014475 A MX 2013014475A MX 2013014475 A MX2013014475 A MX 2013014475A MX 2013014475 A MX2013014475 A MX 2013014475A MX 2013014475 A MX2013014475 A MX 2013014475A
Authority
MX
Mexico
Prior art keywords
antibodies
binding compounds
dsm
auto
adrenoreceptor
Prior art date
Application number
MX2013014475A
Other languages
English (en)
Inventor
Hans-Peter Holthoff
Martin Ungerer
Stefan Zeibig
Martin J Lohse
Roland Jahns
Valerie Jahns
Original Assignee
Corimmun Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corimmun Gmbh filed Critical Corimmun Gmbh
Publication of MX2013014475A publication Critical patent/MX2013014475A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9433—(Nor)adrenaline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos/compuestos de enlace que ligan al segundo bucle extracelular del ß1-adrenoreceptor humano (ß1-AR-ECII) que se producen por/obtienen de una célula huésped/hibridoma con un número de depósito seleccionado del grupo que consiste de DSM ACC3121, DSM ACC3174, DSM ACC3175, DSM ACC3176 y DSM ACC3177. Los anticuerpos/compuestos de enlace son particularmente útiles para determinar anticuerpos auto-anti-ß1-AR en un sistema de ensayo basado en células in vitro a fin de caracterizar e identificar autoanticuerpos dirigidos contra ß1-AR-ECII en una muestra biológica. Adicionales aspectos de la invención son moléculas de ácido nucleico que codifican los compuestos de enlace/anticuerpos, vectores, células huésped, métodos para producir los compuestos de enlace/anticuerpos de la invención así como un equipo que comprende los compuestos de enlace/anticuerpos de la presente invención.
MX2013014475A 2011-06-10 2012-06-06 COMPUESTOS DE ENLACE A ß1-ADRENORECEPTOR HUMANO (ß-AR) Y SU USO EN LA MEDICION DE ANTICUERPOS AUTO-ANTI-ß1-AR. MX2013014475A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11169621 2011-06-10
PCT/EP2012/060776 WO2012168344A1 (en) 2011-06-10 2012-06-06 BINDING COMPOUNDS TO HUMAN β1-ADRENORECEPTOR (β1-AR) AND THEIR USE IN THE MEASUREMENT OF AUTO-ANTI-βA1-AR ANTIBODIES

Publications (1)

Publication Number Publication Date
MX2013014475A true MX2013014475A (es) 2014-05-27

Family

ID=46465188

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014475A MX2013014475A (es) 2011-06-10 2012-06-06 COMPUESTOS DE ENLACE A ß1-ADRENORECEPTOR HUMANO (ß-AR) Y SU USO EN LA MEDICION DE ANTICUERPOS AUTO-ANTI-ß1-AR.

Country Status (10)

Country Link
US (1) US20140273015A1 (es)
EP (1) EP2718324A1 (es)
JP (1) JP2014519329A (es)
CN (1) CN104024275A (es)
AU (1) AU2012266363A1 (es)
BR (1) BR112013031590A2 (es)
CA (1) CA2835231A1 (es)
IL (1) IL229748A0 (es)
MX (1) MX2013014475A (es)
WO (1) WO2012168344A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160222084A1 (en) * 2013-03-15 2016-08-04 The Board Of Regents Of The University Of Oklahoma Compositions Comprising D-Amino Acid Peptides and Methods of Production and Use Thereof for Inhibiting Autoantibodies
WO2019014028A1 (en) * 2017-07-13 2019-01-17 Magarray, Inc. METHOD FOR QUANTIFYING AUTO-ANTIBODIES
WO2022169880A1 (en) * 2021-02-02 2022-08-11 The Cleveland Clinic Foundation Treatment of cvd and systemic sclerosis with beta-1 adrenergic receptor antibodies
EP4392430A1 (en) * 2021-08-27 2024-07-03 Yale University Molecular degraders of extracellular proteins
MX2024002478A (es) * 2021-08-27 2024-06-03 Univ Yale Degradadores moleculares de proteínas extracelulares.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
JP2003514772A (ja) 1999-09-21 2003-04-22 アフィーナ イミュンテヒニク ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｃｍを引き起こす自己抗体に対するペプチド
AU8470301A (en) 2000-08-03 2002-02-18 Wim-Van Schooten Production of humanized antibodies in transgenic animals
EP2518082A3 (en) 2005-03-31 2013-03-13 Julius-Maximilians-Universität Würzburg Means for the inhibition of anti-beta1-adrenergic receptor antibodies
CN1967249A (zh) * 2005-11-15 2007-05-23 华中科技大学同济医学院附属协和医院 抗心肌抗体四联诊断试剂盒
US9062095B2 (en) 2007-08-24 2015-06-23 Julius-Maximilians-Universtitat-Wurzburg Mutant double cyclized receptor peptides inhibiting β1-adrenoceptor antibodies
DE102010018878B4 (de) 2009-04-30 2013-09-26 Julius-Maximilians-Universität Würzburg Neue Zell-Linie zur Fluoreszenz-basierten Detektion von funktionell aktiven Antikörpern und Autoantikörpern gegen den Beta1-adrenergen Rezeptor

Also Published As

Publication number Publication date
CN104024275A (zh) 2014-09-03
WO2012168344A1 (en) 2012-12-13
EP2718324A1 (en) 2014-04-16
CA2835231A1 (en) 2012-12-13
WO2012168344A8 (en) 2013-03-14
IL229748A0 (en) 2014-01-30
US20140273015A1 (en) 2014-09-18
JP2014519329A (ja) 2014-08-14
AU2012266363A1 (en) 2014-01-09
BR112013031590A2 (pt) 2016-11-22

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