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MX2013012385A - Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor. - Google Patents

Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor.

Info

Publication number
MX2013012385A
MX2013012385A MX2013012385A MX2013012385A MX2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A
Authority
MX
Mexico
Prior art keywords
combination
inhibitor
kinase
pi3k
mtor
Prior art date
Application number
MX2013012385A
Other languages
English (en)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013012385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013012385A publication Critical patent/MX2013012385A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La presente invención se refiere a una combinación farmacéutica que comprende un compuesto inhibidor de cinasa de fosfatidil-inositol-3 (PI3K), el cual es un derivado de 2-carboxamida-cicloamino-urea, o una sal farmacéuticamente aceptable del mismo, y cuando menos un inhibidor del objetivo de rapamicina de mamífero (mTOR), o una sal farmacéuticamente aceptable del mismo; a una composición farmacéutica, la cual comprende dicha combinación; y a los usos de esta combinación en el tratamiento de las enfermedades proliferativas, más específicamente de las enfermedades dependientes de la cinasa del objetivo de rapamicina de mamífero (mTOR).
MX2013012385A 2011-04-25 2012-04-23 Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor. MX2013012385A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Publications (1)

Publication Number Publication Date
MX2013012385A true MX2013012385A (es) 2013-11-04

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012385A MX2013012385A (es) 2011-04-25 2012-04-23 Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor.

Country Status (26)

Country Link
US (3) US20140066474A1 (es)
EP (1) EP2701703A1 (es)
JP (2) JP6086902B2 (es)
KR (1) KR101925656B1 (es)
CN (1) CN103491955B (es)
AR (1) AR086481A1 (es)
AU (2) AU2012250010A1 (es)
BR (1) BR112013027486A2 (es)
CA (1) CA2833962A1 (es)
CL (1) CL2013003078A1 (es)
CO (1) CO6801759A2 (es)
EA (1) EA025948B1 (es)
EC (1) ECSP13012994A (es)
GT (1) GT201300263A (es)
IL (1) IL229008A (es)
MA (1) MA35038B1 (es)
MX (1) MX2013012385A (es)
NZ (1) NZ615593A (es)
PE (1) PE20140601A1 (es)
PH (1) PH12013502077A1 (es)
SG (1) SG193919A1 (es)
TN (1) TN2013000392A1 (es)
TW (1) TWI602567B (es)
UA (1) UA110961C2 (es)
WO (1) WO2012148846A1 (es)
ZA (1) ZA201306973B (es)

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BR112014010233A2 (pt) * 2011-11-02 2017-04-18 Novartis Ag derivados de 2-carboxamida cicloamino ureia para uso no tratamento de doenças dependentes de vegf
CN105246482A (zh) * 2013-03-15 2016-01-13 因特利凯有限责任公司 激酶抑制剂的组合及其用途
MX2016006316A (es) * 2013-11-13 2016-07-26 Novartis Ag Inhibidores de mtor para potenciar la respuesta inmunitaria.
US20170165246A1 (en) * 2014-02-11 2017-06-15 Novartis Ag Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
MX2017004359A (es) * 2014-10-03 2017-06-23 Novartis Ag Composiciones farmaceuticas que comprenden alpelisib.
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
JP6691337B2 (ja) * 2016-02-29 2020-04-28 学校法人北里研究所 膀胱癌患者の予後を予測するための方法
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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Also Published As

Publication number Publication date
KR20140012147A (ko) 2014-01-29
JP2017061527A (ja) 2017-03-30
CA2833962A1 (en) 2012-11-01
EP2701703A1 (en) 2014-03-05
CN103491955B (zh) 2015-12-23
KR101925656B1 (ko) 2018-12-05
MA35038B1 (fr) 2014-04-03
EA025948B1 (ru) 2017-02-28
WO2012148846A1 (en) 2012-11-01
ZA201306973B (en) 2014-06-25
JP2014513097A (ja) 2014-05-29
GT201300263A (es) 2015-11-24
UA110961C2 (uk) 2016-03-10
EA201391565A1 (ru) 2014-02-28
CO6801759A2 (es) 2013-11-29
TW201244716A (en) 2012-11-16
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SG193919A1 (en) 2013-11-29
BR112013027486A2 (pt) 2017-02-14
PE20140601A1 (es) 2014-05-24
AR086481A1 (es) 2013-12-18
ECSP13012994A (es) 2013-12-31
PH12013502077A1 (en) 2013-12-16
US20170095463A1 (en) 2017-04-06
JP6086902B2 (ja) 2017-03-01
CL2013003078A1 (es) 2014-05-30
IL229008A0 (en) 2013-12-31
US20140066474A1 (en) 2014-03-06
TN2013000392A1 (en) 2015-01-20
AU2012250010A1 (en) 2013-10-10
IL229008A (en) 2017-11-30
TWI602567B (zh) 2017-10-21
AU2016202372A1 (en) 2016-05-05
CN103491955A (zh) 2014-01-01
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US20180085362A1 (en) 2018-03-29

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