MX2013009948A - Composiciones de insulina y cromo para el tratamiento y prevencion de diabetes, hipoglucemia y alteraciones relacionadas. - Google Patents
Composiciones de insulina y cromo para el tratamiento y prevencion de diabetes, hipoglucemia y alteraciones relacionadas.Info
- Publication number
- MX2013009948A MX2013009948A MX2013009948A MX2013009948A MX2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A
- Authority
- MX
- Mexico
- Prior art keywords
- chromium
- insulin
- hypoglycemia
- prevention
- treatment
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 7
- 229940125396 insulin Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title abstract 3
- 208000013016 Hypoglycemia Diseases 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229910052804 chromium Inorganic materials 0.000 title abstract 3
- 239000011651 chromium Substances 0.000 title abstract 3
- 230000002218 hypoglycaemic effect Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe una composición que comprende cromo e insulina y/o un complejo de cromo-insulina, su método de preparación y su uso en la prevención y tratamiento de hipoglucemia y condiciones relacionadas con hipoglucemia. Esta composición puede ser administrada de numerosas maneras, incluyendo parental, intranasal y oralmente. La composición estabiliza los niveles de glucosa en el suero y tiene efecto sinergista en comparación con cromo e insulina administrados separadamente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448134P | 2011-03-01 | 2011-03-01 | |
| PCT/US2012/027342 WO2012119007A1 (en) | 2011-03-01 | 2012-03-01 | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013009948A true MX2013009948A (es) | 2014-03-27 |
| MX344925B MX344925B (es) | 2017-01-11 |
Family
ID=45841644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013009948A MX344925B (es) | 2011-03-01 | 2012-03-01 | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8933022B2 (es) |
| EP (2) | EP4070801A1 (es) |
| JP (1) | JP6152346B2 (es) |
| KR (1) | KR101836957B1 (es) |
| CN (2) | CN105749253A (es) |
| AU (1) | AU2012223282B2 (es) |
| CA (1) | CA2828572C (es) |
| ES (1) | ES2927800T3 (es) |
| IL (1) | IL228209B (es) |
| MX (1) | MX344925B (es) |
| WO (1) | WO2012119007A1 (es) |
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-
2012
- 2012-03-01 WO PCT/US2012/027342 patent/WO2012119007A1/en not_active Ceased
- 2012-03-01 US US13/409,960 patent/US8933022B2/en active Active
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- 2012-03-01 JP JP2013556874A patent/JP6152346B2/ja not_active Expired - Fee Related
- 2012-03-01 CN CN201610172098.8A patent/CN105749253A/zh active Pending
- 2012-03-01 EP EP22160569.4A patent/EP4070801A1/en not_active Withdrawn
- 2012-03-01 CN CN201280020399.9A patent/CN103702672B/zh not_active Expired - Fee Related
- 2012-03-01 MX MX2013009948A patent/MX344925B/es active IP Right Grant
- 2012-03-01 AU AU2012223282A patent/AU2012223282B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| CN105749253A (zh) | 2016-07-13 |
| WO2012119007A1 (en) | 2012-09-07 |
| KR20140023298A (ko) | 2014-02-26 |
| CA2828572A1 (en) | 2012-09-07 |
| IL228209B (en) | 2020-05-31 |
| CA2828572C (en) | 2021-02-23 |
| EP2680861A1 (en) | 2014-01-08 |
| JP6152346B2 (ja) | 2017-06-21 |
| US8933022B2 (en) | 2015-01-13 |
| AU2012223282A1 (en) | 2013-09-19 |
| US20150094258A1 (en) | 2015-04-02 |
| ES2927800T3 (es) | 2022-11-11 |
| AU2012223282B2 (en) | 2017-02-02 |
| MX344925B (es) | 2017-01-11 |
| KR101836957B1 (ko) | 2018-03-09 |
| CN103702672A (zh) | 2014-04-02 |
| EP2680861B1 (en) | 2022-05-04 |
| CN103702672B (zh) | 2016-04-27 |
| US20120225134A1 (en) | 2012-09-06 |
| EP4070801A1 (en) | 2022-10-12 |
| JP2014506932A (ja) | 2014-03-20 |
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