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MX2013008595A - Procedimiento mejorado para la preparacion de 2,2-difluoroetilamina. - Google Patents

Procedimiento mejorado para la preparacion de 2,2-difluoroetilamina.

Info

Publication number
MX2013008595A
MX2013008595A MX2013008595A MX2013008595A MX2013008595A MX 2013008595 A MX2013008595 A MX 2013008595A MX 2013008595 A MX2013008595 A MX 2013008595A MX 2013008595 A MX2013008595 A MX 2013008595A MX 2013008595 A MX2013008595 A MX 2013008595A
Authority
MX
Mexico
Prior art keywords
chloroethane
difluoro
producing
difluoroethylamine
iii
Prior art date
Application number
MX2013008595A
Other languages
English (en)
Inventor
Norbert Lui
Jens-Dietmar Heinrich
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MX2013008595A publication Critical patent/MX2013008595A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un procedimiento para la preparación de 2,2-difluoroetilamina, que comprende la reacción de 2,2-difluoro-1-cloroetano con una imida de fórmula (II) (Ver Formula) en presencia de un secuestrante de ácido, para dar un compuesto de la fórmula (III) (Ver Formula) en el que, en los compuestos con las fórmulas (II) y (III), cada R1 y R2 son, independientemente entre sí, hidrógeno o alquilo C1-C6 o R1 y R2 forman, junto con los átomos de carbono a los que están unidos, un anillo aromático de seis miembros que está opcionalmente sustituido; y la escisión de 2,2-difluoroetilamina mediante la reacción del compuesto de la fórmula (III) con ácido, base o hidrazina.
MX2013008595A 2011-01-24 2012-01-20 Procedimiento mejorado para la preparacion de 2,2-difluoroetilamina. MX2013008595A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161435497P 2011-01-24 2011-01-24
EP11151873 2011-01-24
PCT/EP2012/050834 WO2012101044A1 (de) 2011-01-24 2012-01-20 Verfahren zur herstellung von 2,2-difluorethylamin ausgehend von 2,2-difluor-1-chlorethan

Publications (1)

Publication Number Publication Date
MX2013008595A true MX2013008595A (es) 2013-08-14

Family

ID=43759169

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008595A MX2013008595A (es) 2011-01-24 2012-01-20 Procedimiento mejorado para la preparacion de 2,2-difluoroetilamina.

Country Status (12)

Country Link
US (1) US8580973B2 (es)
EP (1) EP2668151B1 (es)
JP (1) JP5952305B2 (es)
KR (1) KR20140005994A (es)
CN (1) CN103443067B (es)
BR (1) BR112013018974A2 (es)
DK (1) DK2668151T3 (es)
ES (1) ES2613709T3 (es)
IL (1) IL227592A (es)
MX (1) MX2013008595A (es)
TW (1) TWI518055B (es)
WO (1) WO2012101044A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6182507B2 (ja) * 2014-05-30 2017-08-16 日本曹達株式会社 ２，３−ジハロゲノアニリンの製造方法
CN104030928B (zh) * 2014-06-04 2016-01-20 湖北海之杰化工有限公司 2,2-二氟乙胺的制备方法
CN112645822B (zh) * 2020-12-09 2022-06-07 苏州当量生物医药有限公司 2-氟乙胺盐酸盐的制备方法
KR20220083186A (ko) 2020-12-11 2022-06-20 동우 화인켐 주식회사 고분자 처리용 공정액
IL305145A (en) * 2021-02-17 2023-10-01 Bayer Ag A process for the preparation of polyfluoroalkylamines from polyfluoroalkylalcohols
KR20220129246A (ko) 2021-03-16 2022-09-23 동우 화인켐 주식회사 고분자 처리용 공정액 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030994A (en) * 1971-06-18 1977-06-21 Merck & Co., Inc. Substitutive fluorination of organic compounds
HU223057B1 (hu) * 1997-12-15 2004-03-01 Richter Gedeon Vegyészeti Gyár Rt. Eljárás helyettesített allilamin-származék és sói előállítására
JP2001131177A (ja) * 1999-11-08 2001-05-15 Ohara Yakuhin Kogyo Kk ジベンズ［ｃ，ｆ］イミダゾ［１，５−ａ］アゼピンの製造方法及びその製造中間体
JP2002308851A (ja) * 2001-04-13 2002-10-23 Daito Kk ６−アミノメチル−６，１１−ジヒドロ−５Ｈ−ジベンゾ［ｂ，ｅ］アゼピンの製造方法
DE102006015467A1 (de) * 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
WO2008134327A1 (en) * 2007-04-26 2008-11-06 Dow Global Technologies Inc. Method of producing amino dialkoxy aldehydes via hydroformylation
EP2039684A1 (de) * 2007-09-18 2009-03-25 Bayer CropScience AG Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
RU2537186C2 (ru) * 2008-12-22 2014-12-27 Пола Кемикал Индастриз Инк. Ингибитор продуцирования меланина
FR2941454B1 (fr) * 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran
WO2010123999A2 (en) * 2009-04-21 2010-10-28 Auspex Pharmaceuticals, Inc. 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor

Also Published As

Publication number Publication date
CN103443067B (zh) 2015-04-22
ES2613709T3 (es) 2017-05-25
JP2014511347A (ja) 2014-05-15
IL227592A (en) 2015-05-31
US20120190867A1 (en) 2012-07-26
TW201235336A (en) 2012-09-01
BR112013018974A2 (pt) 2017-03-21
EP2668151A1 (de) 2013-12-04
WO2012101044A1 (de) 2012-08-02
TWI518055B (zh) 2016-01-21
JP5952305B2 (ja) 2016-07-13
KR20140005994A (ko) 2014-01-15
CN103443067A (zh) 2013-12-11
EP2668151B1 (de) 2016-11-16
US8580973B2 (en) 2013-11-12
IL227592A0 (en) 2013-09-30
DK2668151T3 (en) 2017-01-30

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