MX2013007678A - Moleculas de acido nucleico dirigidas ala pequeña proteina de union de gtp rho1 y que confieren resistencia a las plagas de coleopteros. - Google Patents
Moleculas de acido nucleico dirigidas ala pequeña proteina de union de gtp rho1 y que confieren resistencia a las plagas de coleopteros.Info
- Publication number
- MX2013007678A MX2013007678A MX2013007678A MX2013007678A MX2013007678A MX 2013007678 A MX2013007678 A MX 2013007678A MX 2013007678 A MX2013007678 A MX 2013007678A MX 2013007678 A MX2013007678 A MX 2013007678A MX 2013007678 A MX2013007678 A MX 2013007678A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- acid molecules
- coleopteran pests
- target
- binding protein
- Prior art date
Links
- 241000607479 Yersinia pestis Species 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102100023818 ADP-ribosylation factor 3 Human genes 0.000 title 1
- 101000684275 Homo sapiens ADP-ribosylation factor 3 Proteins 0.000 title 1
- 101001130437 Homo sapiens Ras-related protein Rap-2b Proteins 0.000 title 1
- 101150069512 RHO1 gene Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Insects & Arthropods (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pest Control & Pesticides (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Esta descripción se refiere a moléculas de ácido nucleico y a los métodos para su uso para contorlar plagas de coleópteros mediante la inhibición mediada por interferencia de ARN las secuencias codificantes de la objetivo y secuencias no codificantes transcritas en plagas de coleópteros. La descripción también se refiere a métodos para producir plantas transgénicas que expresan las moléculas de ácido nucléico útiles para el control de las plagas de coleópteros y las células de plantas y las plantas así obtenidas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061428688P | 2010-12-30 | 2010-12-30 | |
| PCT/US2011/068188 WO2012092596A2 (en) | 2010-12-30 | 2011-12-30 | Nucleic acid molecules that target the rho1 small gtp-binding protein and confer resistance to coleopteran pests |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013007678A true MX2013007678A (es) | 2013-07-30 |
Family
ID=46382059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013007678A MX2013007678A (es) | 2010-12-30 | 2011-12-30 | Moleculas de acido nucleico dirigidas ala pequeña proteina de union de gtp rho1 y que confieren resistencia a las plagas de coleopteros. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9012722B2 (es) |
| EP (2) | EP3354735A1 (es) |
| JP (1) | JP2014503218A (es) |
| KR (1) | KR20130130805A (es) |
| CN (2) | CN107937405A (es) |
| AP (1) | AP2013007005A0 (es) |
| AR (1) | AR084777A1 (es) |
| AU (1) | AU2011351969A1 (es) |
| BR (1) | BRPI1107330B1 (es) |
| CA (1) | CA2823367A1 (es) |
| CL (1) | CL2013001925A1 (es) |
| CO (1) | CO6731141A2 (es) |
| MX (1) | MX2013007678A (es) |
| RU (1) | RU2013135491A (es) |
| UY (1) | UY33852A (es) |
| WO (1) | WO2012092596A2 (es) |
| ZA (1) | ZA201305151B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY33854A (es) | 2010-12-30 | 2012-07-31 | Dow Agrosciences Llc | Moléculas de ácido nucleico que se dirigen a la subunidad c de la atpasa vacuolar y confieren resistencia a las plagas de coleópteros |
| BRPI1107329A2 (pt) * | 2010-12-30 | 2019-11-19 | Dow Agrosciences Llc | moléculas de ácido nucléico que direcionadas à subunidade h de atpase vacuolar que conferem resistência a pragas de coleópteros, vetor de transformação de planta, célula transformada, bem como métodos para controlar uma população de praga de coleóptero, controlar uma infestação pela dita praga, melhorar o rendimento de uma safra e para produzir uma célula transgênica |
| PH12013501409A1 (en) | 2010-12-30 | 2019-06-03 | Dow Agrosciences Llc | Nucleic acid molecules that confer resistance to coleopteran pests |
| BR102014031844A2 (pt) * | 2013-12-20 | 2015-10-06 | Dow Agrosciences Llc | ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros |
| WO2015095750A1 (en) | 2013-12-20 | 2015-06-25 | Dow Agrosciences Llc | Rnapii-140 nucleic acid molecules that confer resistance to coleopteran pests |
| RU2016139492A (ru) | 2014-03-12 | 2018-04-12 | Дзе Юниверсити Оф Сидней | Продукция рнк у высших растений |
| TW201623613A (zh) * | 2014-05-07 | 2016-07-01 | 陶氏農業科學公司 | 賦予對鞘翅目害蟲之抵抗力的dre4核酸分子 |
| BR102015025537A2 (pt) * | 2014-10-08 | 2016-04-12 | Dow Agrosciences Llc | moléculas de ácidos nucleicos gho/sec24b2 e sec24b1 para controlar pragas de coleópteros e de hemípteros |
| US20160194658A1 (en) | 2014-12-22 | 2016-07-07 | Dow Agrosciences Llc | Nucampholin nucleic acid molecules to control coleopteran insect pests |
| EP3067424A1 (en) | 2015-03-13 | 2016-09-14 | Dow AgroSciences LLC | Rna polymerase i1 nucleic acid molecules to control insect pests |
| BR102016012010A2 (pt) | 2015-05-29 | 2020-03-24 | Dow Agrosciences Llc | Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica |
| CA2999147A1 (en) * | 2015-09-25 | 2017-03-30 | Dow Agrosciences Llc | Shibire/dynamin nucleic acid molecules to control coleopteran and hemipteran pests |
| AU2016337355B2 (en) * | 2015-10-12 | 2019-09-26 | Dow Agrosciences Llc | WupA nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
| CN105779475A (zh) * | 2016-03-15 | 2016-07-20 | 浙江大学 | 一种罗伦隐球酵母rho1基因cDNA序列及其编码的Rho1GTP蛋白 |
| CN105779318B (zh) * | 2016-03-15 | 2019-02-05 | 浙江大学 | 一种用于表达罗伦隐球酵母Rho1GTP蛋白的酿酒酵母基因工程菌、其构建方法及其应用 |
| AR109206A1 (es) | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
| AR109205A1 (es) | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
| JP2019524147A (ja) | 2016-08-17 | 2019-09-05 | モンサント テクノロジー エルエルシー | 収穫可能収量を増加させるためのジベレリン代謝操作を介して低草高植物を得るための方法及び組成物 |
| EP3342780A1 (en) | 2016-12-30 | 2018-07-04 | Dow AgroSciences LLC | Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests |
| AR113761A1 (es) | 2017-10-18 | 2020-06-10 | Syngenta Participations Ag | Control de plagas de hemípteros utilizando moléculas de arn |
| EP3751987A4 (en) | 2018-02-15 | 2021-11-10 | Monsanto Technology LLC | IMPROVED METHODS FOR MANUFACTURING HYBRID CORN SEEDS |
| WO2019162163A1 (en) | 2018-02-26 | 2019-08-29 | Devgen Nv | Control of insect pests using rna molecules |
| WO2019206780A1 (en) | 2018-04-27 | 2019-10-31 | Devgen Nv | Control of insect pests using rna molecules |
| US12274205B2 (en) | 2018-12-12 | 2025-04-15 | Monsanto Technology Llc | Delayed harvest of short stature corn plants |
| CA3129553A1 (en) | 2019-03-21 | 2020-09-24 | Lien DE SCHRIJVER | Control of insect pests using rna molecules |
| US12527250B2 (en) | 2020-11-23 | 2026-01-20 | Monsanto Technology Llc | Methods for improved hybrid corn seed production |
| WO2024047148A1 (en) | 2022-09-01 | 2024-03-07 | Syngenta Crop Protection Ag | Control of insect pests using rna molecules |
| KR102807005B1 (ko) | 2022-12-26 | 2025-05-13 | 국립경국대학교 산학협력단 | vATPase를 표적으로 하는 꽃노랑총채벌레 방제용 조성물 및 이를 이용한 꽃노랑총채벌레의 방제방법 |
| WO2024223802A2 (en) | 2023-04-26 | 2024-10-31 | Syngenta Crop Protection Ag | Control of plant pests using rna molecules |
| KR20260001569A (ko) | 2024-06-26 | 2026-01-06 | 국립경국대학교 산학협력단 | vATPase를 표적으로 하는 총채벌레 방제용 조성물, 이를 이용한 총채벌레 방제방법 및 dsRNA의 살충 활성을 향상시키는 방법 |
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| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
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| US5352605A (en) | 1983-01-17 | 1994-10-04 | Monsanto Company | Chimeric genes for transforming plant cells using viral promoters |
| DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| FR2596761B1 (fr) | 1986-04-08 | 1988-05-20 | Commissariat Energie Atomique | Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides |
| US5322938A (en) | 1987-01-13 | 1994-06-21 | Monsanto Company | DNA sequence for enhancing the efficiency of transcription |
| US5359142A (en) | 1987-01-13 | 1994-10-25 | Monsanto Company | Method for enhanced expression of a protein |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| US5789214A (en) | 1988-03-08 | 1998-08-04 | Novartis Finance Corporation | Method of inducing gene transcription in a plant |
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| US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
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| US5659026A (en) | 1995-03-24 | 1997-08-19 | Pioneer Hi-Bred International | ALS3 promoter |
| US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
| DE19631919C2 (de) | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US6140078A (en) | 1996-09-05 | 2000-10-31 | Unilever Patent Holdings | Salt-inducible promoter derivable from a lactic acid bacterium, and its use in a lactic acid bacterium for production of a desired protein |
| BR9807488A (pt) | 1997-01-20 | 2000-03-21 | Plant Genetic Systems Nv | Promotores de planta induzidos por agentes patogênicos. |
| US5922564A (en) | 1997-02-24 | 1999-07-13 | Performance Plants, Inc. | Phosphate-deficiency inducible promoter |
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| CA2315549A1 (en) | 1998-02-26 | 1999-09-02 | Pioneer Hi-Bred International, Inc. | Family of maize pr-1 genes and promoters |
| US6307123B1 (en) | 1998-05-18 | 2001-10-23 | Dekalb Genetics Corporation | Methods and compositions for transgene identification |
| JP2000083680A (ja) | 1998-07-16 | 2000-03-28 | Nippon Paper Industries Co Ltd | 光誘導型プロモ―タ―の制御下に置かれた不定芽再分化遺伝子を選抜マ―カ―遺伝子とする植物への遺伝子導入方法及びこれに用いる植物への遺伝子導入用ベクタ― |
| US6194636B1 (en) | 1999-05-14 | 2001-02-27 | Dekalb Genetics Corp. | Maize RS324 promoter and methods for use thereof |
| US6429357B1 (en) | 1999-05-14 | 2002-08-06 | Dekalb Genetics Corp. | Rice actin 2 promoter and intron and methods for use thereof |
| US6232526B1 (en) | 1999-05-14 | 2001-05-15 | Dekalb Genetics Corp. | Maize A3 promoter and methods for use thereof |
| US6207879B1 (en) | 1999-05-14 | 2001-03-27 | Dekalb Genetics Corporation | Maize RS81 promoter and methods for use thereof |
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| US20020048814A1 (en) | 2000-08-15 | 2002-04-25 | Dna Plant Technology Corporation | Methods of gene silencing using poly-dT sequences |
| US7612194B2 (en) * | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| EP1818405B2 (en) * | 2004-04-09 | 2025-03-19 | Monsanto Technology, LLC | Compositions and methods for control of insect infestations in plants |
| EP1824967B1 (en) | 2004-12-21 | 2014-11-05 | Monsanto Technology, LLC | Recombinant dna constructs and methods for controlling gene expression |
| US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| EP2439279B1 (en) | 2005-09-16 | 2016-11-09 | Monsanto Technology LLC | Methods for genetic control of insect infestations in plants and compositions thereof |
| AR077095A1 (es) | 2009-06-16 | 2011-08-03 | Dow Agrosciences Llc | Toxinas cry dig-10 insecticidas |
| UY33854A (es) | 2010-12-30 | 2012-07-31 | Dow Agrosciences Llc | Moléculas de ácido nucleico que se dirigen a la subunidad c de la atpasa vacuolar y confieren resistencia a las plagas de coleópteros |
| BRPI1107329A2 (pt) | 2010-12-30 | 2019-11-19 | Dow Agrosciences Llc | moléculas de ácido nucléico que direcionadas à subunidade h de atpase vacuolar que conferem resistência a pragas de coleópteros, vetor de transformação de planta, célula transformada, bem como métodos para controlar uma população de praga de coleóptero, controlar uma infestação pela dita praga, melhorar o rendimento de uma safra e para produzir uma célula transgênica |
| PH12013501409A1 (en) | 2010-12-30 | 2019-06-03 | Dow Agrosciences Llc | Nucleic acid molecules that confer resistance to coleopteran pests |
-
2011
- 2011-12-30 KR KR1020137020040A patent/KR20130130805A/ko not_active Withdrawn
- 2011-12-30 EP EP18162476.8A patent/EP3354735A1/en not_active Withdrawn
- 2011-12-30 WO PCT/US2011/068188 patent/WO2012092596A2/en not_active Ceased
- 2011-12-30 CN CN201711158997.3A patent/CN107937405A/zh active Pending
- 2011-12-30 RU RU2013135491/10A patent/RU2013135491A/ru not_active Application Discontinuation
- 2011-12-30 UY UY0001033852A patent/UY33852A/es not_active Application Discontinuation
- 2011-12-30 BR BRPI1107330A patent/BRPI1107330B1/pt not_active IP Right Cessation
- 2011-12-30 CN CN2011800688444A patent/CN103403164A/zh active Pending
- 2011-12-30 EP EP11852649.0A patent/EP2658976A4/en not_active Withdrawn
- 2011-12-30 US US13/341,752 patent/US9012722B2/en not_active Expired - Fee Related
- 2011-12-30 CA CA2823367A patent/CA2823367A1/en not_active Abandoned
- 2011-12-30 AU AU2011351969A patent/AU2011351969A1/en not_active Abandoned
- 2011-12-30 MX MX2013007678A patent/MX2013007678A/es not_active Application Discontinuation
- 2011-12-30 JP JP2013547707A patent/JP2014503218A/ja not_active Withdrawn
- 2011-12-30 AP AP2013007005A patent/AP2013007005A0/xx unknown
-
2012
- 2012-01-04 AR ARP120100017A patent/AR084777A1/es unknown
-
2013
- 2013-06-28 CL CL2013001925A patent/CL2013001925A1/es unknown
- 2013-07-09 ZA ZA2013/05151A patent/ZA201305151B/en unknown
- 2013-07-30 CO CO13180365A patent/CO6731141A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012092596A3 (en) | 2012-10-26 |
| BRPI1107330A2 (pt) | 2018-03-06 |
| RU2013135491A (ru) | 2015-02-10 |
| EP3354735A1 (en) | 2018-08-01 |
| UY33852A (es) | 2012-07-31 |
| AU2011351969A1 (en) | 2013-07-25 |
| CA2823367A1 (en) | 2012-07-05 |
| WO2012092596A2 (en) | 2012-07-05 |
| EP2658976A2 (en) | 2013-11-06 |
| AR084777A1 (es) | 2013-06-26 |
| ZA201305151B (en) | 2014-09-25 |
| JP2014503218A (ja) | 2014-02-13 |
| BRPI1107330B1 (pt) | 2020-01-28 |
| CN107937405A (zh) | 2018-04-20 |
| CO6731141A2 (es) | 2013-08-15 |
| KR20130130805A (ko) | 2013-12-02 |
| CL2013001925A1 (es) | 2014-03-28 |
| AP2013007005A0 (en) | 2013-07-31 |
| US20120174260A1 (en) | 2012-07-05 |
| EP2658976A4 (en) | 2014-10-22 |
| CN103403164A (zh) | 2013-11-20 |
| US9012722B2 (en) | 2015-04-21 |
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