[go: up one dir, main page]

MX2013004724A - Compuestos de tiazolida alquilsulfinilo-sustituidos. - Google Patents

Compuestos de tiazolida alquilsulfinilo-sustituidos.

Info

Publication number
MX2013004724A
MX2013004724A MX2013004724A MX2013004724A MX2013004724A MX 2013004724 A MX2013004724 A MX 2013004724A MX 2013004724 A MX2013004724 A MX 2013004724A MX 2013004724 A MX2013004724 A MX 2013004724A MX 2013004724 A MX2013004724 A MX 2013004724A
Authority
MX
Mexico
Prior art keywords
alkylsulfinyl
thiazolide compounds
substituted
substituted thiazolide
compounds
Prior art date
Application number
MX2013004724A
Other languages
English (en)
Inventor
J Edward Semple
Jean-Francois Rossignol
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Publication of MX2013004724A publication Critical patent/MX2013004724A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe una nueva clase de alquilsulfinil tiazolidas. Estos compuestos muestran fuerte actividad contra los virus de hepatitis.
MX2013004724A 2010-11-01 2011-10-27 Compuestos de tiazolida alquilsulfinilo-sustituidos. MX2013004724A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40893810P 2010-11-01 2010-11-01
PCT/US2011/058009 WO2012061190A1 (en) 2010-11-01 2011-10-27 Alkylsulfinyl-substituted thiazolide compounds

Publications (1)

Publication Number Publication Date
MX2013004724A true MX2013004724A (es) 2013-08-29

Family

ID=45997374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004724A MX2013004724A (es) 2010-11-01 2011-10-27 Compuestos de tiazolida alquilsulfinilo-sustituidos.

Country Status (11)

Country Link
US (1) US8772502B2 (es)
EP (1) EP2635124A4 (es)
JP (1) JP5837936B2 (es)
CN (1) CN103269593A (es)
AR (1) AR087725A1 (es)
AU (1) AU2011323682B2 (es)
BR (1) BR112013010738B1 (es)
MX (1) MX2013004724A (es)
NZ (1) NZ611410A (es)
RU (1) RU2605745C2 (es)
WO (1) WO2012061190A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103159697A (zh) * 2013-04-10 2013-06-19 安徽中升药业有限公司 硝唑尼特的制备方法
US10131643B2 (en) 2013-07-04 2018-11-20 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China Tizoxanide carbamate and pharmaceutical use thereof
JP6633092B2 (ja) 2014-11-11 2020-01-22 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニド、その類似体又は塩のプロドラッグを用いる組成物及び治療方法
CN108289961A (zh) 2016-03-31 2018-07-17 罗马克实验室有限公司 用于治疗病毒性感染的噻唑化物化合物
MX375099B (es) * 2016-04-06 2025-03-06 Innovative Molecules Gmbh Derivados de aminotiazol útiles como agentes antivíricos.
DK3442580T3 (da) 2016-04-11 2020-12-21 Genfit Fremgangsmåder til behandling af kolestatiske og fibrotiske sygdomme
WO2018195035A1 (en) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase a3
CN107522595A (zh) * 2017-09-08 2017-12-29 山西新元太新材料科技发展有限公司 一种制备间苯二酚的工艺方法
CN107556201B (zh) * 2017-09-08 2020-10-27 山西智创药研科技有限公司 一种制备间氨基苯酚的工艺方法
WO2019068817A1 (en) * 2017-10-05 2019-04-11 Innovative Molecules Gmbh SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS
WO2019241376A1 (en) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof
CN118978524A (zh) * 2019-09-11 2024-11-19 绍兴君科臻元医药科技有限公司 硝唑尼特衍生物及其医药用途
FR3110164A1 (fr) * 2020-05-15 2021-11-19 Phv Pharma Procédé de préparation du nitazoxanide et de ses dérivés et utilisation pour la prévention ou le traitement d’états pathologiques dus à l’infection par des virus du type coronavirus, et plus particulièrement du type SARS-CoV-2
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
CN116367892A (zh) 2020-08-24 2023-06-30 罗马克实验室有限公司 噻唑化物抗冠状病毒的用途
WO2024211836A2 (en) * 2023-04-05 2024-10-10 Moma Therapeutics, Inc. Semi-saturated bicyclic derivatives and related uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169846A (en) 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
US5578621A (en) 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
DE10129714A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
WO2008123469A1 (ja) * 2007-03-30 2008-10-16 Japan Tobacco Inc. ６員環アミド化合物およびその用途
ES2550755T3 (es) 2007-08-03 2015-11-12 Romark Laboratories, L.C. Compuestos de tiazolida sustituidos con alquilsulfonilo
BRPI1014322A2 (pt) * 2009-06-26 2015-08-25 Romark Lab Lc Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica.

Also Published As

Publication number Publication date
US20120108591A1 (en) 2012-05-03
EP2635124A1 (en) 2013-09-11
RU2013123401A (ru) 2014-12-10
RU2605745C2 (ru) 2016-12-27
US8772502B2 (en) 2014-07-08
EP2635124A4 (en) 2014-04-16
BR112013010738B1 (pt) 2020-03-17
JP5837936B2 (ja) 2015-12-24
JP2013544806A (ja) 2013-12-19
CN103269593A (zh) 2013-08-28
AU2011323682A1 (en) 2013-06-20
BR112013010738A2 (pt) 2016-07-12
NZ611410A (en) 2016-02-26
WO2012061190A1 (en) 2012-05-10
AR087725A1 (es) 2014-04-16
AU2011323682B2 (en) 2016-06-23

Similar Documents

Publication Publication Date Title
MX2013004724A (es) Compuestos de tiazolida alquilsulfinilo-sustituidos.
MX2010001358A (es) Compuestos de tiazolida sustituidos con alquilsulfonilo.
MX2011012040A (es) Compuestos de haloalquil heteroaril benzamida.
PH12020550552A1 (en) Inhibitors of hepatitis c virus
MD20140135A2 (ro) Inhibitori macrociclici ai viruşilor din familia Flaviviridae
NZ703040A (en) Macrocyclic inhibitors of flaviviridae viruses
CR20120417A (es) Inhibidores de virus flaviviridae
NZ703066A (en) Macrocyclic inhibitors of flaviviridae viruses
PH12013500770A1 (en) Inhibitors of hepatitis c virus
MX2013006475A (es) Inhibidores macrociclicos de virus flaviviridae.
PH12015501017A1 (en) Alternative uses for hbv assembly effectors
IL229459B (en) Use of thiazolide compounds against hiv
MX2012008221A (es) Inhibidores de virus flaviviridae.
PH12015502031A1 (en) Tetrahydropyrrolothiazine compounds
IL224369B (en) Combinations of inhibitors for hepatitis c virus
EA201690894A1 (ru) Феноксиэтилы
IN2015DN00446A (es)
UA114325C2 (uk) Феноксіетилпіперидинові сполуки
IN2014CN04449A (es)
ZA201406194B (en) Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor
PH12015502032A1 (en) Azetidinyloxyphenylpyrrolidine compounds
MX2013006185A (es) Compuestos de 6-(piridinilmetoxi) -pirrolopiridina 3-sustituidos.

Legal Events

Date Code Title Description
FG Grant or registration