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MX2013003859A - Polimorfos de picropodofilina b o c para su uso en la terapia del cancer. - Google Patents

Polimorfos de picropodofilina b o c para su uso en la terapia del cancer.

Info

Publication number
MX2013003859A
MX2013003859A MX2013003859A MX2013003859A MX2013003859A MX 2013003859 A MX2013003859 A MX 2013003859A MX 2013003859 A MX2013003859 A MX 2013003859A MX 2013003859 A MX2013003859 A MX 2013003859A MX 2013003859 A MX2013003859 A MX 2013003859A
Authority
MX
Mexico
Prior art keywords
polymorphs
picropodophyllin
cancer therapy
therapy
preparing
Prior art date
Application number
MX2013003859A
Other languages
English (en)
Inventor
Mikael Bisrat
Magnus Brisander
Original Assignee
Axelar Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axelar Ab filed Critical Axelar Ab
Publication of MX2013003859A publication Critical patent/MX2013003859A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se relaciona con nuevos polimorfos de picropodofilina, métodos para la preparación de dichos polimorfos y composiciones farmacéuticas que comprenden dichos polimorfos, así como el uso de dichos polimorfos en terapia tal como en la terapia del cáncer. (ver Fórmula).
MX2013003859A 2010-10-08 2011-10-07 Polimorfos de picropodofilina b o c para su uso en la terapia del cancer. MX2013003859A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39111410P 2010-10-08 2010-10-08
US39111010P 2010-10-08 2010-10-08
US41001410P 2010-11-04 2010-11-04
US201161488190P 2011-05-20 2011-05-20
PCT/SE2011/051207 WO2012047171A1 (en) 2010-10-08 2011-10-07 Picropodophyllin polymorphs b or c for use in cancer therapy

Publications (1)

Publication Number Publication Date
MX2013003859A true MX2013003859A (es) 2013-07-29

Family

ID=45927976

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003859A MX2013003859A (es) 2010-10-08 2011-10-07 Polimorfos de picropodofilina b o c para su uso en la terapia del cancer.

Country Status (13)

Country Link
US (1) US9314525B2 (es)
EP (1) EP2624827A4 (es)
JP (1) JP2013538872A (es)
KR (1) KR20140001211A (es)
CN (1) CN103269700A (es)
AU (1) AU2011312905A1 (es)
BR (1) BR112013008232A2 (es)
CA (1) CA2812921A1 (es)
IL (1) IL225465A0 (es)
MX (1) MX2013003859A (es)
RU (1) RU2013120990A (es)
SG (1) SG189295A1 (es)
WO (1) WO2012047171A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103189381B (zh) 2010-08-31 2016-06-08 阿克塞拉公司 制备环木脂体的新方法
CA2912254C (en) 2013-05-10 2021-06-08 M. Alphabet 2, L.L.C. Methods of treating skin conditions using cyclolignan compounds
CN110669054B (zh) * 2018-07-03 2022-04-26 南京药石科技股份有限公司 胰岛素样生长因子-1受体酪氨酸激酶抑制剂及其用途
CN116143797A (zh) * 2021-11-19 2023-05-23 杭州拿因生物科技有限责任公司 苦鬼臼毒素衍生物、其药物组合物及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052917A (es) 1963-05-22
JPS511453A (en) * 1974-06-19 1976-01-08 Sumitomo Chemical Co Beeta nafutooruno seiseihoho
SE0102168D0 (sv) 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
SE0203747D0 (sv) * 2002-12-18 2002-12-18 Karolinska Innovations Ab New use
JP2009527551A (ja) 2006-02-24 2009-07-30 アクセラー エービー ２型糖尿病の治療用および避妊薬としてのシクロリグナンの使用
CN101492704B (zh) 2008-01-21 2011-09-21 湖北工业大学 将鬼臼毒素转化为鬼臼酸和鬼臼苦素的方法
JP2011525486A (ja) 2008-06-23 2011-09-22 アクセラー エービー 活動亢進性免疫系を治療するためのシクロリグナンの使用
CN103189381B (zh) 2010-08-31 2016-06-08 阿克塞拉公司 制备环木脂体的新方法
CA2812926A1 (en) 2010-10-08 2012-04-12 Axelar Ab Picropodophyllin monohydrate or polymorph a in cancer therapy

Also Published As

Publication number Publication date
KR20140001211A (ko) 2014-01-06
CN103269700A (zh) 2013-08-28
WO2012047171A1 (en) 2012-04-12
US9314525B2 (en) 2016-04-19
BR112013008232A2 (pt) 2019-09-24
SG189295A1 (en) 2013-05-31
RU2013120990A (ru) 2014-11-20
EP2624827A1 (en) 2013-08-14
IL225465A0 (en) 2013-06-27
EP2624827A4 (en) 2014-05-28
CA2812921A1 (en) 2012-04-12
JP2013538872A (ja) 2013-10-17
AU2011312905A1 (en) 2013-04-11
US20130317099A1 (en) 2013-11-28

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