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MX2013003439A - Produccion de alfa-olefinas usando policetida-sintasas. - Google Patents

Produccion de alfa-olefinas usando policetida-sintasas.

Info

Publication number
MX2013003439A
MX2013003439A MX2013003439A MX2013003439A MX2013003439A MX 2013003439 A MX2013003439 A MX 2013003439A MX 2013003439 A MX2013003439 A MX 2013003439A MX 2013003439 A MX2013003439 A MX 2013003439A MX 2013003439 A MX2013003439 A MX 2013003439A
Authority
MX
Mexico
Prior art keywords
olefins
producing alpha
polyketide synthases
pks
olefin
Prior art date
Application number
MX2013003439A
Other languages
English (en)
Inventor
Jeffrey L Fortman
Leonard Katz
Eric J Steen
Jay D Keasling
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2013003439A publication Critical patent/MX2013003439A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/002—Preparation of hydrocarbons or halogenated hydrocarbons cyclic
    • C12P5/005—Preparation of hydrocarbons or halogenated hydrocarbons cyclic aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención provee una policetida-sintasa (PKS) capaz de sintetizar una a-olefina, tal como 1-hexeno o butadieno. La presente invención provee una célula huésped que comprende la PKS y cuando se cultiva produce la a-olefina.
MX2013003439A 2010-09-28 2011-09-28 Produccion de alfa-olefinas usando policetida-sintasas. MX2013003439A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38743510P 2010-09-28 2010-09-28
PCT/US2011/053787 WO2012050931A2 (en) 2010-09-28 2011-09-28 Producing alpha-olefins using polyketide synthases

Publications (1)

Publication Number Publication Date
MX2013003439A true MX2013003439A (es) 2013-07-17

Family

ID=45938883

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003439A MX2013003439A (es) 2010-09-28 2011-09-28 Produccion de alfa-olefinas usando policetida-sintasas.

Country Status (11)

Country Link
US (2) US20130267696A1 (es)
EP (1) EP2622085A4 (es)
JP (1) JP2013544500A (es)
KR (1) KR20130123388A (es)
CN (1) CN103249837A (es)
AU (1) AU2011314084B2 (es)
BR (1) BR112013007441A2 (es)
CA (1) CA2812763A1 (es)
MX (1) MX2013003439A (es)
SG (2) SG188654A1 (es)
WO (1) WO2012050931A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102575265B (zh) 2009-06-22 2016-03-30 焦耳无限科技公司 在工程化的微生物中的1-烯烃的生物合成
WO2012058606A1 (en) * 2010-10-28 2012-05-03 Joule Unlimited Technologies, Inc. Methods and compositions for the recombinant biosynthesis of terminal olefins
JP6010342B2 (ja) * 2012-05-21 2016-10-19 株式会社ブリヂストン イソプレン−ブタジエン共重合体、イソプレン−ブタジエン共重合体の製造方法、ゴム組成物及びタイヤ
JP6010343B2 (ja) * 2012-05-21 2016-10-19 株式会社ブリヂストン イソプレン−ブタジエン共重合体、イソプレン−ブタジエン共重合体の製造方法、ゴム組成物及びタイヤ
JP6074160B2 (ja) * 2012-05-22 2017-02-01 株式会社ブリヂストン ゴム組成物およびタイヤの製造方法
JP6074161B2 (ja) * 2012-05-22 2017-02-01 株式会社ブリヂストン ゴム組成物およびタイヤの製造方法
JP2015524283A (ja) 2012-08-10 2015-08-24 オーピーエックス バイオテクノロジーズ， インコーポレイテッド 脂肪酸および脂肪酸由来生成物の生成のため微生物および方法
JP5536840B2 (ja) 2012-09-07 2014-07-02 住友ゴム工業株式会社 タイヤ用ゴム組成物、タイヤ部材、及び空気入りタイヤ
US10047383B2 (en) 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US10337038B2 (en) 2013-07-19 2019-07-02 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
JP6532192B2 (ja) * 2014-04-24 2019-06-19 住友ゴム工業株式会社 タイヤ用ゴム組成物、タイヤ部材、及び空気入りタイヤ
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
WO2017011407A2 (en) * 2015-07-10 2017-01-19 The Regents Of The University Of California Producing adipic acid and related compounds using hybrid polyketide synthases
CN105176942A (zh) * 2015-08-04 2015-12-23 北京农学院 来源于树莓的聚酮合酶RinPKS1及其相关生物材料与应用
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
US11414365B2 (en) 2018-01-30 2022-08-16 Inolex Investment Corporation Natural 1,2-alkanediols, compositions having natural 1,2-alkanediols and processes for making the same
US12241104B2 (en) 2020-04-01 2025-03-04 The Regents Of The University Of California Use of metal salts and deep eutectic solvents in a process to solubilize a biomass
US12392085B2 (en) 2020-04-28 2025-08-19 The Regents Of The University Of California Use of in-situ ionic liquid (IL) and deep eutectic solvent (DES) synthesis using chemically synthesized or biomass-derived ions in the pretreatment of biomass
US12371855B2 (en) 2020-04-28 2025-07-29 The Regents Of The University Of California Use of ensiled biomass for increased efficiency of the pretreatment of biomass
US12098171B2 (en) 2020-12-11 2024-09-24 The Regents Of The University Of California Hybrid sugar transporters with altered sugar transport activity and uses thereof
US11884620B2 (en) 2020-12-11 2024-01-30 The Regents Of The University Of California Use of polyamines in the pretreatment of biomass
CN116426450A (zh) * 2023-04-01 2023-07-14 中国科学院微生物研究所 菌株及其在制备泰乐菌素a中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558942B1 (en) * 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6410301B1 (en) * 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6998256B2 (en) * 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
WO2002012534A2 (en) 2000-08-09 2002-02-14 Kosan Biosciences, Inc. Bio-intermediates for use in the chemical synthesis of polyketides
BR0115877A (pt) * 2000-11-20 2003-10-07 Cargill Inc ácido 3-hidroxipropiÈnico e outros compostos orgánicos
US20050227316A1 (en) 2004-04-07 2005-10-13 Kosan Biosciences, Inc. Synthetic genes
BRPI0909839A2 (pt) * 2008-03-28 2017-06-13 Univ California produção de ácidos dicarboxílicos usando policetídeo sintases
US8420833B2 (en) * 2008-04-29 2013-04-16 The Regents Of The University Of California Producing biofuels using polyketide synthases
CN102575265B (zh) * 2009-06-22 2016-03-30 焦耳无限科技公司 在工程化的微生物中的1-烯烃的生物合成
US8765431B2 (en) * 2009-07-23 2014-07-01 The Regents Of The University Of Michigan Method for enzymatic production of decarboxylated polyketides and fatty acids

Also Published As

Publication number Publication date
CA2812763A1 (en) 2012-04-19
BR112013007441A2 (pt) 2017-07-04
US9856461B2 (en) 2018-01-02
KR20130123388A (ko) 2013-11-12
EP2622085A4 (en) 2014-04-02
WO2012050931A2 (en) 2012-04-19
AU2011314084B2 (en) 2016-06-02
AU2011314084A1 (en) 2013-05-02
JP2013544500A (ja) 2013-12-19
EP2622085A2 (en) 2013-08-07
SG188654A1 (en) 2013-04-30
SG10201508018SA (en) 2015-11-27
CN103249837A (zh) 2013-08-14
US20130267696A1 (en) 2013-10-10
US20160068827A1 (en) 2016-03-10
WO2012050931A3 (en) 2012-06-21

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