MX2013002649A - Agente terapeutico contra el dolor. - Google Patents
Agente terapeutico contra el dolor.Info
- Publication number
- MX2013002649A MX2013002649A MX2013002649A MX2013002649A MX2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A MX 2013002649 A MX2013002649 A MX 2013002649A
- Authority
- MX
- Mexico
- Prior art keywords
- pain
- therapeutic agent
- inventors
- useful
- treatment
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 6
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 triazole compound Chemical class 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003852 triazoles Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporciona un producto farmacéutico, particularmente, una composición farmacéutica que es útil para el tratamiento del dolor. Los actuales inventores han realizado estudios exhaustivos al usar los animales modelo con dolor para el propósito de proporcionar un agente terapéutico contra el dolor. Consecuentemente, han encontrado que el inhibidor de 11ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD1, por sus siglas en inglés), particularmente, un compuesto de triazol que tiene un grupo cíclico en la posición 3 (o en la posición 5) de un anillo de triazol, tiene un buen efecto de mejorar el dolor crónico. Es decir, de acuerdo con la presente invención, una composición farmacéutica que comprende un inhibidor de 11ß-HSD1, particularmente, el compuesto de triazol de la presente invención, como un ingrediente activo, es útil para el tratamiento del dolor (particularmente, del dolor neuropático o de la fibromialgia).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010200305 | 2010-09-07 | ||
| PCT/JP2011/070205 WO2012033070A1 (ja) | 2010-09-07 | 2011-09-06 | 疼痛治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013002649A true MX2013002649A (es) | 2013-04-05 |
Family
ID=45810669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013002649A MX2013002649A (es) | 2010-09-07 | 2011-09-06 | Agente terapeutico contra el dolor. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9765040B2 (es) |
| EP (1) | EP2614824B1 (es) |
| JP (1) | JP5822079B2 (es) |
| KR (1) | KR101747486B1 (es) |
| CN (2) | CN107041885A (es) |
| AU (1) | AU2011299905B2 (es) |
| BR (1) | BR112013005532A2 (es) |
| CA (1) | CA2809778C (es) |
| CY (1) | CY1116274T1 (es) |
| DK (1) | DK2614824T3 (es) |
| EA (1) | EA022338B1 (es) |
| ES (1) | ES2533310T3 (es) |
| HR (1) | HRP20150544T1 (es) |
| IL (1) | IL224920A (es) |
| MX (1) | MX2013002649A (es) |
| PH (1) | PH12013500371A1 (es) |
| PL (1) | PL2614824T3 (es) |
| PT (1) | PT2614824E (es) |
| SI (1) | SI2614824T1 (es) |
| TW (1) | TWI486336B (es) |
| UA (1) | UA112418C2 (es) |
| WO (1) | WO2012033070A1 (es) |
| ZA (1) | ZA201301458B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014009524A2 (pt) | 2011-10-18 | 2017-05-09 | Astellas Pharma Inc | composto heterocíclico bicíclico |
| US9994658B2 (en) | 2015-10-02 | 2018-06-12 | Exxonmobil Chemical Patents Inc. | Polymerization process using bis phenolate compounds supported on organoaluminum treated layered silicate supports |
| WO2017096148A1 (en) * | 2015-12-03 | 2017-06-08 | Katz Robert S | Methods and systems for diagnosing and treating fibromyalgia |
| RU2643583C1 (ru) * | 2016-10-24 | 2018-02-02 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО УГМУ Минздрава России) | Способ лечения хронических болевых синдромов, сформировавшихся на основе посттравматического стрессового расстройства, сочетающегося с последствиями боевой черепно-мозговой травмы |
| WO2018117063A1 (ja) * | 2016-12-20 | 2018-06-28 | アステラス製薬株式会社 | 焦燥性興奮治療剤 |
| AU2019384074B2 (en) * | 2018-11-20 | 2025-04-10 | Sparrow Pharmaceuticals, Inc. | Methods for administering corticosteroids |
| AU2023273030A1 (en) | 2022-05-16 | 2024-11-07 | Sparrow Pharmaceuticals, Inc. | Methods and compositions for treating glucocorticoid excess |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR878201A0 (en) * | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| JP4637578B2 (ja) | 2002-08-09 | 2011-02-23 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類 |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| EP1615698B1 (en) | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
| EP1677819A1 (en) * | 2003-10-10 | 2006-07-12 | Novo Nordisk A/S | Long-acting molecules in sustained release formulations |
| WO2005044192A2 (en) | 2003-10-28 | 2005-05-19 | Amgen Inc. | Triazole compounds and uses related thereto |
| JP2005170939A (ja) * | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
| KR20060101772A (ko) | 2003-12-19 | 2006-09-26 | 화이자 인코포레이티드 | 당뇨병 및 비만을 치료하기 위한,11-베타-하이드록시스테로이드 데하이드로게나제 유형1(11-베타-ｈｓｄ-1)의 저해제로서의벤젠설폰일아미노-피리딘-2-일 유도체 및 관련 화합물 |
| CN1909902A (zh) | 2003-12-22 | 2007-02-07 | 伊莱利利公司 | 用于治疗糖尿病的作为ppar调节剂的三唑、噁二唑和噻二唑衍生物 |
| WO2006030805A1 (ja) * | 2004-09-16 | 2006-03-23 | Astellas Pharma Inc. | トリアゾール誘導体またはその塩 |
| JP2008518903A (ja) | 2004-11-02 | 2008-06-05 | ファイザー・インク | 置換および非置換アダマンチルアミドの新規化合物 |
| WO2006134481A1 (en) | 2005-06-16 | 2006-12-21 | Pfizer Inc. | Inhibitors of 11-beta hydroxysteroid dehydrogenase type 1 |
| WO2006134467A1 (en) | 2005-06-16 | 2006-12-21 | Pfizer Inc. | N-(pyridin-2-yl)-sulfonamide derivatives |
| CN101198605A (zh) | 2005-06-16 | 2008-06-11 | 辉瑞大药厂 | N-(吡啶-2-基)-磺酰胺衍生物 |
| US7853951B2 (en) * | 2005-07-25 | 2010-12-14 | Intel Corporation | Lock sequencing to reorder and grant lock requests from multiple program threads |
| EP1922068A4 (en) | 2005-08-16 | 2010-08-11 | Icagen Inc | INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS |
| AR058807A1 (es) | 2005-09-29 | 2008-02-27 | Astrazeneca Ab | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
| TWI391378B (zh) | 2006-03-16 | 2013-04-01 | Astellas Pharma Inc | 喹啉酮衍生物或其製藥學上可被容許之鹽 |
| BRPI0708782A2 (pt) | 2006-03-16 | 2011-06-14 | Astellas Pharma Inc | derivado de triazol ou um sal deste |
| SMT201700154T1 (it) * | 2008-07-03 | 2017-05-08 | Astellas Pharma Inc | Derivato di triazolo o suo sale |
| FR2948211B1 (fr) * | 2009-07-17 | 2011-08-05 | Airbus Operations Sas | Methode de routage des liaisons physiques d'une plateforme avionique |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
-
2011
- 2011-06-09 UA UAA201304329A patent/UA112418C2/uk unknown
- 2011-09-06 CA CA2809778A patent/CA2809778C/en not_active Expired - Fee Related
- 2011-09-06 TW TW100132078A patent/TWI486336B/zh not_active IP Right Cessation
- 2011-09-06 PT PT118235456T patent/PT2614824E/pt unknown
- 2011-09-06 SI SI201130469T patent/SI2614824T1/sl unknown
- 2011-09-06 BR BR112013005532A patent/BR112013005532A2/pt not_active Application Discontinuation
- 2011-09-06 CN CN201710421919.1A patent/CN107041885A/zh active Pending
- 2011-09-06 EA EA201390345A patent/EA022338B1/ru not_active IP Right Cessation
- 2011-09-06 DK DK11823545.6T patent/DK2614824T3/en active
- 2011-09-06 KR KR1020137008722A patent/KR101747486B1/ko not_active Expired - Fee Related
- 2011-09-06 CN CN201180042963.2A patent/CN103079564B/zh not_active Expired - Fee Related
- 2011-09-06 ES ES11823545.6T patent/ES2533310T3/es active Active
- 2011-09-06 WO PCT/JP2011/070205 patent/WO2012033070A1/ja not_active Ceased
- 2011-09-06 HR HRP20150544TT patent/HRP20150544T1/hr unknown
- 2011-09-06 AU AU2011299905A patent/AU2011299905B2/en not_active Ceased
- 2011-09-06 US US13/820,873 patent/US9765040B2/en not_active Expired - Fee Related
- 2011-09-06 PH PH1/2013/500371A patent/PH12013500371A1/en unknown
- 2011-09-06 EP EP11823545.6A patent/EP2614824B1/en active Active
- 2011-09-06 PL PL11823545T patent/PL2614824T3/pl unknown
- 2011-09-06 JP JP2012532977A patent/JP5822079B2/ja not_active Expired - Fee Related
- 2011-09-06 MX MX2013002649A patent/MX2013002649A/es active IP Right Grant
-
2013
- 2013-02-26 IL IL224920A patent/IL224920A/en not_active IP Right Cessation
- 2013-02-26 ZA ZA2013/01458A patent/ZA201301458B/en unknown
-
2015
- 2015-05-13 CY CY20151100424T patent/CY1116274T1/el unknown
-
2017
- 2017-07-31 US US15/664,733 patent/US20170327474A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |