MX2013002394A - Nuevo microorganismo mutante productor de acido succinico que utiliza sacarosa y glicerol simultaneamente, y metodo para producir acido succinico utilizando el mismo. - Google Patents
Nuevo microorganismo mutante productor de acido succinico que utiliza sacarosa y glicerol simultaneamente, y metodo para producir acido succinico utilizando el mismo.Info
- Publication number
- MX2013002394A MX2013002394A MX2013002394A MX2013002394A MX2013002394A MX 2013002394 A MX2013002394 A MX 2013002394A MX 2013002394 A MX2013002394 A MX 2013002394A MX 2013002394 A MX2013002394 A MX 2013002394A MX 2013002394 A MX2013002394 A MX 2013002394A
- Authority
- MX
- Mexico
- Prior art keywords
- succinic acid
- sucrose
- glycerol
- mutant microorganism
- microorganism producing
- Prior art date
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title abstract 12
- 239000001384 succinic acid Substances 0.000 title abstract 6
- 244000005700 microbiome Species 0.000 title abstract 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title abstract 4
- 229930006000 Sucrose Natural products 0.000 title abstract 4
- 239000005720 sucrose Substances 0.000 title abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003313 weakening effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un microorganismo mutante productor de ácido succínico que es capaz de utilizar sacarosa y glicerol como fuentes de carbono simultáneamente. Más particularmente, la presente invención se refiere a un microorganismo mutante productor de ácido succínico que es capaz de utilizar sacarosa y glicerol al mismo tiempo para la producción de ácido succínico, el organismo mutante se obtiene al sustituir el mecanismo de represión catabólica de glicerol mediado por sacarosa en un microorganismo productor de ácido succínico. Como se ha descrito anteriormente, cuando se cultiva el microorganismo mutante productor de ácido succínico, éste utiliza sacarosa y glicerol simultáneamente de modo que el ácido succínico puede ser producido con alta productividad con un rendimiento máximo que se aproxima el rendimiento teórico, mientras que la producción de subproductos se reduce al mínimo. Además, de acuerdo con la presente invención, diversos productos químicos reducidos, que han sido producidos en bajos rendimientos en los métodos convencionales, pueden ser más eficazmente producidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100084327A KR101221557B1 (ko) | 2010-08-30 | 2010-08-30 | 수크로오즈와 글리세롤을 동시에 이용하는 신규 숙신산 생성 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| PCT/KR2011/006382 WO2012030130A2 (ko) | 2010-08-30 | 2011-08-30 | 수크로오즈와 글리세롤을 동시에 이용하는 신규 숙신산 생성 변이 미생물 및 이를 이용한 숙신산 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013002394A true MX2013002394A (es) | 2013-12-16 |
| MX344549B MX344549B (es) | 2016-12-20 |
Family
ID=45773370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013002394A MX344549B (es) | 2010-08-30 | 2011-08-30 | Nuevo microorganismo mutante productor de acido succinico que utiliza sacarosa y glicerol simultaneamente, y metodo para producir acido succinico utilizando el mismo. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8691516B2 (es) |
| EP (2) | EP2993225B1 (es) |
| JP (1) | JP5805768B2 (es) |
| KR (1) | KR101221557B1 (es) |
| CN (2) | CN103249832B (es) |
| AU (1) | AU2011296791B2 (es) |
| BR (1) | BR112013004652B1 (es) |
| CA (1) | CA2809942C (es) |
| DK (1) | DK2612905T3 (es) |
| ES (2) | ES2602780T3 (es) |
| MX (1) | MX344549B (es) |
| MY (1) | MY183660A (es) |
| NZ (1) | NZ607585A (es) |
| PH (1) | PH12013500378A1 (es) |
| RU (1) | RU2537003C2 (es) |
| WO (1) | WO2012030130A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100780324B1 (ko) | 2006-07-28 | 2007-11-29 | 한국과학기술원 | 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법 |
| US9657316B2 (en) | 2012-08-27 | 2017-05-23 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto |
| CN104995293A (zh) | 2012-12-17 | 2015-10-21 | 基因组股份公司 | 用于在甲醇的存在下提高还原当量的可用性,以及用于生产与此有关的己二酸、6-氨基己酸、六亚甲基二胺或己内酰胺的微生物体和方法 |
| JP2017505134A (ja) * | 2014-02-07 | 2017-02-16 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | ショ糖における改善されたファインケミカルの生産のための改変微生物 |
| EP3119898A1 (en) * | 2014-03-19 | 2017-01-25 | Basf Se | The use of glycerol with limited feed of carbohydrates for fermentation |
| JP6608392B2 (ja) * | 2014-05-08 | 2019-11-20 | ビーエーエスエフ ソシエタス・ヨーロピア | ショ糖におけるファインケミカルの改善された生産のための遺伝的改変微生物 |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| CN110747147B (zh) * | 2019-11-29 | 2021-05-28 | 江南大学 | 一株衣康酸胁迫抗性提高的大肠杆菌 |
| WO2025023634A1 (ko) * | 2023-07-21 | 2025-01-30 | 한국과학기술원 | 마그네슘 트랜스포터가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159738A (en) * | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| KR100372218B1 (ko) * | 2000-06-29 | 2003-02-14 | 바이오인포메틱스 주식회사 | 유기산을 생산하는 균주 및 이를 이용한 유기산의 생산방법 |
| WO2005052135A1 (en) * | 2003-11-27 | 2005-06-09 | Korea Advanced Institute Of Science And Technology | Novel rumen bacteria variants and process for preparing succinic acid employing the same |
| WO2007013695A1 (ja) * | 2005-07-29 | 2007-02-01 | Nippon Shokubai Co., Ltd. | 細菌にグリセリン資化能を付与する方法 |
| DE102005047596A1 (de) * | 2005-10-05 | 2007-04-12 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| KR100780324B1 (ko) * | 2006-07-28 | 2007-11-29 | 한국과학기술원 | 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법 |
| EP2147970B1 (en) * | 2007-04-17 | 2014-12-31 | Ajinomoto Co., Inc. | A method for producing an acidic substance having a carboxyl group |
| CN103589662A (zh) * | 2007-08-17 | 2014-02-19 | 巴斯夫欧洲公司 | 巴斯德氏菌科的羧酸产生成员 |
| WO2009048202A1 (en) * | 2007-10-09 | 2009-04-16 | Korea Advanced Institute Of Science And Technology | Method for preparing succinic acid using glycerol as carbon source |
| MY160380A (en) * | 2008-10-28 | 2017-03-15 | Glycos Biotechnologies Incorporated | Microaerobic cultures for converting glycerol to chemicals |
| KR101093199B1 (ko) * | 2009-02-12 | 2011-12-12 | 한국과학기술원 | 글리세롤 대사능력 및 숙신산 생산능력이 향상된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR101823695B1 (ko) * | 2009-02-16 | 2018-03-14 | 바스프 에스이 | 신규 미생물 숙신산 생산자 및 숙신산의 정제 |
| BR112013014688B1 (pt) * | 2010-12-13 | 2021-09-28 | Myriant Corporation | Bactérias escherichia coli geneticamente alteradas |
| KR20160116352A (ko) * | 2011-07-22 | 2016-10-07 | 미리안트 코포레이션 | 유기산으로의 글리세롤의 발효 |
-
2010
- 2010-08-30 KR KR1020100084327A patent/KR101221557B1/ko active Active
-
2011
- 2011-08-30 AU AU2011296791A patent/AU2011296791B2/en active Active
- 2011-08-30 JP JP2013527009A patent/JP5805768B2/ja active Active
- 2011-08-30 EP EP15188336.0A patent/EP2993225B1/en active Active
- 2011-08-30 MY MYPI2013000662A patent/MY183660A/en unknown
- 2011-08-30 CN CN201180051937.6A patent/CN103249832B/zh active Active
- 2011-08-30 NZ NZ607585A patent/NZ607585A/en unknown
- 2011-08-30 CA CA2809942A patent/CA2809942C/en active Active
- 2011-08-30 ES ES11822105.0T patent/ES2602780T3/es active Active
- 2011-08-30 WO PCT/KR2011/006382 patent/WO2012030130A2/ko not_active Ceased
- 2011-08-30 US US13/819,339 patent/US8691516B2/en active Active
- 2011-08-30 MX MX2013002394A patent/MX344549B/es active IP Right Grant
- 2011-08-30 RU RU2013109055/10A patent/RU2537003C2/ru active
- 2011-08-30 CN CN201510616196.1A patent/CN105154381A/zh active Pending
- 2011-08-30 EP EP11822105.0A patent/EP2612905B1/en active Active
- 2011-08-30 PH PH1/2013/500378A patent/PH12013500378A1/en unknown
- 2011-08-30 DK DK11822105.0T patent/DK2612905T3/en active
- 2011-08-30 BR BR112013004652-0A patent/BR112013004652B1/pt active IP Right Grant
- 2011-08-30 ES ES15188336.0T patent/ES2654512T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2612905A4 (en) | 2014-12-17 |
| EP2612905A2 (en) | 2013-07-10 |
| CN105154381A (zh) | 2015-12-16 |
| EP2612905B1 (en) | 2016-10-05 |
| US8691516B2 (en) | 2014-04-08 |
| CA2809942C (en) | 2016-04-12 |
| EP2993225A3 (en) | 2016-04-20 |
| WO2012030130A2 (ko) | 2012-03-08 |
| CN103249832A (zh) | 2013-08-14 |
| AU2011296791A1 (en) | 2013-04-11 |
| EP2993225B1 (en) | 2017-11-29 |
| BR112013004652B1 (pt) | 2021-05-18 |
| MX344549B (es) | 2016-12-20 |
| JP2013539368A (ja) | 2013-10-24 |
| WO2012030130A3 (ko) | 2012-06-28 |
| ES2654512T3 (es) | 2018-02-14 |
| DK2612905T3 (en) | 2016-12-12 |
| EP2993225A2 (en) | 2016-03-09 |
| AU2011296791B2 (en) | 2015-05-21 |
| KR20120020614A (ko) | 2012-03-08 |
| RU2013109055A (ru) | 2014-09-10 |
| CN103249832B (zh) | 2016-09-21 |
| MY183660A (en) | 2021-03-05 |
| JP5805768B2 (ja) | 2015-11-10 |
| PH12013500378A1 (en) | 2017-01-06 |
| US20130217087A1 (en) | 2013-08-22 |
| CA2809942A1 (en) | 2012-03-08 |
| RU2537003C2 (ru) | 2014-12-27 |
| NZ607585A (en) | 2014-08-29 |
| ES2602780T3 (es) | 2017-02-22 |
| KR101221557B1 (ko) | 2013-01-14 |
| BR112013004652A2 (pt) | 2016-07-05 |
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| FG | Grant or registration |