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MX2011010964A - Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano. - Google Patents

Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano.

Info

Publication number
MX2011010964A
MX2011010964A MX2011010964A MX2011010964A MX2011010964A MX 2011010964 A MX2011010964 A MX 2011010964A MX 2011010964 A MX2011010964 A MX 2011010964A MX 2011010964 A MX2011010964 A MX 2011010964A MX 2011010964 A MX2011010964 A MX 2011010964A
Authority
MX
Mexico
Prior art keywords
ccr2
azetidinyl
phenyl
antagonists
cyclohexane
Prior art date
Application number
MX2011010964A
Other languages
English (en)
Inventor
Zhihua Sui
Dana L Johnson
Xuqing Zhang
Cuifen Hou
Heather Rae Hufnagal
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2011010964A publication Critical patent/MX2011010964A/es

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    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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Abstract

La presente invención comprende compuestos de la Fórmula (I) (ver fórmula (I)) en donde: X, R1, R2, R3 y R4 son como se definieron en la descripción; la invención comprende, además, un método para prevenir, tratar o mejorar un síndrome, trastorno o enfermedad, en donde ese síndrome, trastorno o enfermedad es diabetes tipo II, obesidad y asma; la invención comprende, además, un método para inhibir la actividad de la CCR2 en un mamífero por medio de la administración de una cantidad terapéuticamente efectiva de al menos un compuesto de la Fórmula (I).
MX2011010964A 2009-04-17 2010-04-15 Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano. MX2011010964A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17030709P 2009-04-17 2009-04-17
PCT/US2010/031265 WO2010121046A1 (en) 2009-04-17 2010-04-15 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

Publications (1)

Publication Number Publication Date
MX2011010964A true MX2011010964A (es) 2011-11-02

Family

ID=42167720

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011010964A MX2011010964A (es) 2009-04-17 2010-04-15 Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano.

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Country Link
US (2) US20100267689A1 (es)
EP (1) EP2419419B1 (es)
JP (1) JP5675773B2 (es)
KR (1) KR20120006544A (es)
CN (1) CN102459227B (es)
AR (1) AR076328A1 (es)
AU (1) AU2010236346B2 (es)
BR (1) BRPI1016189A2 (es)
CA (1) CA2758934A1 (es)
ES (1) ES2528625T3 (es)
MX (1) MX2011010964A (es)
NZ (1) NZ595432A (es)
TW (1) TW201102377A (es)
WO (1) WO2010121046A1 (es)

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JP5675773B2 (ja) 2015-02-25
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WO2010121046A1 (en) 2010-10-21
EP2419419A1 (en) 2012-02-22
TW201102377A (en) 2011-01-16
JP2012524111A (ja) 2012-10-11
US8513229B2 (en) 2013-08-20
EP2419419B1 (en) 2014-12-03
US20120040960A1 (en) 2012-02-16
CN102459227A (zh) 2012-05-16
BRPI1016189A2 (pt) 2016-04-19
US20100267689A1 (en) 2010-10-21
CA2758934A1 (en) 2010-10-21
AU2010236346B2 (en) 2015-01-22
KR20120006544A (ko) 2012-01-18
AR076328A1 (es) 2011-06-01

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