MX2012008740A - Metodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4. - Google Patents
Metodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4.Info
- Publication number
- MX2012008740A MX2012008740A MX2012008740A MX2012008740A MX2012008740A MX 2012008740 A MX2012008740 A MX 2012008740A MX 2012008740 A MX2012008740 A MX 2012008740A MX 2012008740 A MX2012008740 A MX 2012008740A MX 2012008740 A MX2012008740 A MX 2012008740A
- Authority
- MX
- Mexico
- Prior art keywords
- dii4
- methods
- disorders
- diseases
- disease
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 10
- 201000010099 disease Diseases 0.000 abstract 5
- 208000035475 disorder Diseases 0.000 abstract 5
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 108700041286 delta Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 101150109170 dll4 gene Proteins 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención provee métodos de tratamiento de una enfermedad o trastorno, en los cuales el incremento en el número de células T reguladoras (Tregs) es benéfico, administrando a un sujeto que padece dicha enfermedad o trastorno una cantidad terapéuticamente efectiva de antagonistas de D114 que bloquean las vías de señal de D114-Notch, incrementando así el número de Treg. Las enfermedades o trastornos tratables por los métodos de la invención incluyen enfermedades o trastornos autoinmunes, tales como esclerosis múltiple (MS), diabetes y similares. Los antagonistas de D114 adecuados para la invención incluyen anticuerpos o fragmentos de anticuerpo que se unen específicamente a D114 y bloquean las interacciones D114-Notch, el dominio extracelular de D114 y similares. La invención también provee métodos para prevenir la ocurrencia o recurrencia de dichas enfermedades o trastornos en un sujeto predispuesto o susceptible a desarrollar dichas enfermedades o trastornos. Además, los métodos de la invención son útiles para prevenir o tratar rechazos de trasplante de órganos o enfermedad de injerto versus hospedero.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29980110P | 2010-01-29 | 2010-01-29 | |
| US36168710P | 2010-07-06 | 2010-07-06 | |
| US38869710P | 2010-10-01 | 2010-10-01 | |
| PCT/US2011/022810 WO2011094465A1 (en) | 2010-01-29 | 2011-01-28 | Methods of treating autoimmune diseases with dll4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2012008740A true MX2012008740A (es) | 2012-08-31 |
| MX343553B MX343553B (es) | 2016-11-10 |
Family
ID=43925413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008740A MX343553B (es) | 2010-01-29 | 2011-01-28 | Métodos de tratamiento de enfermedades autoinmunes con antagonistas de ligando tipo delta 4. |
| MX2012008638A MX343555B (es) | 2010-01-29 | 2011-01-28 | Métodos de tratamiento de diabetes con antagonistas de ligando tipo delta 4. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008638A MX343555B (es) | 2010-01-29 | 2011-01-28 | Métodos de tratamiento de diabetes con antagonistas de ligando tipo delta 4. |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8765125B2 (es) |
| EP (2) | EP2528945B1 (es) |
| JP (2) | JP5997613B2 (es) |
| KR (2) | KR101797918B1 (es) |
| CN (2) | CN102947336B (es) |
| AR (1) | AR080026A1 (es) |
| AU (2) | AU2011210771B2 (es) |
| BR (2) | BR112012018820A8 (es) |
| CA (2) | CA2787394C (es) |
| CY (2) | CY1118223T1 (es) |
| DK (2) | DK2528945T3 (es) |
| ES (2) | ES2609663T3 (es) |
| HR (2) | HRP20170249T1 (es) |
| HU (2) | HUE031432T2 (es) |
| IL (2) | IL220887A (es) |
| JO (2) | JO3183B1 (es) |
| LT (2) | LT2528945T (es) |
| MX (2) | MX343553B (es) |
| MY (2) | MY156538A (es) |
| PL (2) | PL2528945T3 (es) |
| PT (2) | PT2528945T (es) |
| RS (2) | RS55715B1 (es) |
| RU (2) | RU2587624C2 (es) |
| SG (4) | SG182528A1 (es) |
| SI (2) | SI2528946T1 (es) |
| SM (3) | SMT201600412B (es) |
| TW (2) | TWI600433B (es) |
| UY (1) | UY33206A (es) |
| WO (2) | WO2011094465A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
| JO3183B1 (ar) * | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
| UA112743C2 (uk) | 2010-03-02 | 2016-10-25 | Еббві Інк. | Терапевтичний dll4-зв'язувальний білок |
| LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| KR101535341B1 (ko) | 2012-07-02 | 2015-07-13 | 한화케미칼 주식회사 | Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도 |
| MY194330A (en) | 2012-11-01 | 2022-11-28 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof |
| TW201438736A (zh) * | 2012-11-14 | 2014-10-16 | Regeneron Pharma | 以ｄｌｌ４拮抗劑治療卵巢癌之方法 |
| US10184010B2 (en) | 2013-07-09 | 2019-01-22 | Ablbio | Dual-targeting protein binding specifically to DLL4 and VEGF and use thereof |
| JP6560200B2 (ja) * | 2013-10-17 | 2019-08-14 | ザ ジェネラル ホスピタル コーポレイション | 自己免疫疾患の治療に応答性の対象を同定する方法およびそれを治療するための組成物 |
| WO2015154795A1 (en) * | 2014-04-08 | 2015-10-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Combination therapy for the treatment of autoimmune diseases |
| EP3212233B1 (en) | 2014-10-31 | 2020-06-24 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| US11446262B2 (en) | 2018-11-29 | 2022-09-20 | Debora Zucco Sassi Yonezawa Siviglia | Neuroquiescence—a treatment for neurodevelopmental and neurodegenerative bioelectrical dysregulation and demyelination |
| EP3886856A4 (en) * | 2018-11-29 | 2022-01-19 | Zucco Sassi Yonezawa Siviglia, Debora | METHOD FOR TREATING OR PREVENTING SEIZURES ASSOCIATED WITH AN EPILEPTIC DISORDER |
| JPWO2022210802A1 (es) * | 2021-03-30 | 2022-10-06 | ||
| WO2023159166A1 (en) * | 2022-02-18 | 2023-08-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Single-domain antibodies (nanobodies) targeting the notch ligand dll4 and methods of their use |
| WO2025212726A2 (en) | 2024-04-04 | 2025-10-09 | Compass Therapeutics, Inc. | Combination of antibodies targeting dll4/vegf and cd137 agonists or anti-pd1/anti-pd-l1 antibodies for the treatment of cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| EP1505977B1 (en) * | 2002-05-21 | 2014-09-10 | Gilead Sciences, Inc. | Administration of a partial fatty acid oxidation inhibitor such as ranolazine for the treatment of diabetes |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| US20060134121A1 (en) | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
| DK1962895T3 (da) | 2005-12-16 | 2013-03-04 | Regeneron Pharma | TERAPEUTISK ANVENDELSE AF EN Dll4-ANTAGONIST OG EN VEGF-HÆMMER TIL HÆMNING AF TUMORVÆKST |
| HRP20120175T1 (hr) | 2006-06-02 | 2012-03-31 | Regeneron Pharmaceuticals | Antitijela s visokim afinitetom za humani il-6 receptor |
| MX2008015541A (es) * | 2006-06-06 | 2008-12-18 | Genentech Inc | Anticuerpos anti-dll4 y metodos que los usan. |
| US20080014196A1 (en) | 2006-06-06 | 2008-01-17 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| JP5529536B2 (ja) * | 2006-08-07 | 2014-06-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 虚血性障害又は血管不全の治療におけるＤｌｌ４アンタゴニストの使用 |
| US7750124B2 (en) | 2006-09-29 | 2010-07-06 | Oncomed Pharmaceuticals, Inc. | Anti-human DLL4 antibodies and compositions |
| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| JO3183B1 (ar) * | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
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2011
- 2011-01-23 JO JOP/2011/0021A patent/JO3183B1/ar active
- 2011-01-26 AR ARP110100250A patent/AR080026A1/es unknown
- 2011-01-28 MX MX2012008740A patent/MX343553B/es active IP Right Grant
- 2011-01-28 HU HUE11701933A patent/HUE031432T2/en unknown
- 2011-01-28 JP JP2012551293A patent/JP5997613B2/ja active Active
- 2011-01-28 AU AU2011210771A patent/AU2011210771B2/en active Active
- 2011-01-28 SM SM201600412T patent/SMT201600412B/it unknown
- 2011-01-28 CA CA2787394A patent/CA2787394C/en active Active
- 2011-01-28 RS RS20170142A patent/RS55715B1/sr unknown
- 2011-01-28 RS RS20170036A patent/RS55595B1/sr unknown
- 2011-01-28 TW TW105101963A patent/TWI600433B/zh not_active IP Right Cessation
- 2011-01-28 BR BR112012018820A patent/BR112012018820A8/pt not_active Application Discontinuation
- 2011-01-28 EP EP11701735.0A patent/EP2528945B1/en active Active
- 2011-01-28 HR HRP20170249TT patent/HRP20170249T1/hr unknown
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