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MX2012008152A - Proceso para preparar voriconazol utilizando nuevos intermediarios. - Google Patents

Proceso para preparar voriconazol utilizando nuevos intermediarios.

Info

Publication number
MX2012008152A
MX2012008152A MX2012008152A MX2012008152A MX2012008152A MX 2012008152 A MX2012008152 A MX 2012008152A MX 2012008152 A MX2012008152 A MX 2012008152A MX 2012008152 A MX2012008152 A MX 2012008152A MX 2012008152 A MX2012008152 A MX 2012008152A
Authority
MX
Mexico
Prior art keywords
chemical formula
voriconazole
preparing
preparing voriconazole
racemicvoriconazole
Prior art date
Application number
MX2012008152A
Other languages
English (en)
Inventor
Hyuk Chul Kwon
Man Dong Rho
Kyung Hoi Cha
Original Assignee
Dong Kook Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42645839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012008152(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dong Kook Pharm Co Ltd filed Critical Dong Kook Pharm Co Ltd
Publication of MX2012008152A publication Critical patent/MX2012008152A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se provee un proceso para preparar voriconazol representado por la fórmula química 1. Más en particular, el proceso para preparar voriconazol de la fórmula química 1 incluye: llevar a cabo la reacción de acoplamiento del tipo Reformatsky entre un derivado de cetona de la fórmula química 4 y un derivado de pirimidina de la fórmula química 5, para obtener un compuesto de la fórmula química 3; hacer reaccionar los sustituyentes halógeno y oxisulfonilo con un donador de hidrógeno para obtener voriconazol racémico de la fórmula química 2; y llevar a cabo el aislamiento óptico del voriconazol racémico, añadiéndole un ácido ópticamente activo adecuado para obtener voriconazol que tiene elevada pureza óptica, con alta relación de costo-eficiencia y gran rendimiento. (Fórmula química 1) (Ver Formula).
MX2012008152A 2010-02-04 2011-02-01 Proceso para preparar voriconazol utilizando nuevos intermediarios. MX2012008152A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100010467A KR100971371B1 (ko) 2010-02-04 2010-02-04 신규한 중간체를 이용한 보리코나졸의 제조방법
PCT/KR2011/000689 WO2011096697A2 (en) 2010-02-04 2011-02-01 Process for preparing voriconazole by using new intermediates

Publications (1)

Publication Number Publication Date
MX2012008152A true MX2012008152A (es) 2012-08-23

Family

ID=42645839

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008152A MX2012008152A (es) 2010-02-04 2011-02-01 Proceso para preparar voriconazol utilizando nuevos intermediarios.

Country Status (9)

Country Link
US (1) US8575344B2 (es)
EP (1) EP2531499B1 (es)
JP (1) JP5553911B2 (es)
KR (1) KR100971371B1 (es)
BR (1) BR112012019620A2 (es)
ES (1) ES2518892T3 (es)
MX (1) MX2012008152A (es)
PE (1) PE20130043A1 (es)
WO (1) WO2011096697A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101435741B1 (ko) * 2013-01-17 2014-08-29 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
KR101709543B1 (ko) * 2014-12-09 2017-02-23 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
CN114829354A (zh) * 2019-12-24 2022-07-29 刘杰 一种伏立康唑对映异构体的回收方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069442B1 (en) 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9516121D0 (en) 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
EP1899327A1 (en) 2005-06-30 2008-03-19 MSN Laboratories Limited Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole)
CA2640922A1 (en) * 2006-02-01 2007-11-22 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
WO2009084029A2 (en) 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol

Also Published As

Publication number Publication date
BR112012019620A2 (pt) 2022-05-10
PE20130043A1 (es) 2013-02-04
JP2013518876A (ja) 2013-05-23
EP2531499A2 (en) 2012-12-12
US20130005973A1 (en) 2013-01-03
WO2011096697A2 (en) 2011-08-11
WO2011096697A3 (en) 2011-12-15
KR100971371B1 (ko) 2010-07-20
ES2518892T3 (es) 2014-11-05
US8575344B2 (en) 2013-11-05
JP5553911B2 (ja) 2014-07-23
EP2531499B1 (en) 2014-07-23
EP2531499A4 (en) 2013-06-26

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