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MX2012007835A - Derivados de oxazolopirimidina sustituida en 2, 5,7. - Google Patents

Derivados de oxazolopirimidina sustituida en 2, 5,7.

Info

Publication number
MX2012007835A
MX2012007835A MX2012007835A MX2012007835A MX2012007835A MX 2012007835 A MX2012007835 A MX 2012007835A MX 2012007835 A MX2012007835 A MX 2012007835A MX 2012007835 A MX2012007835 A MX 2012007835A MX 2012007835 A MX2012007835 A MX 2012007835A
Authority
MX
Mexico
Prior art keywords
derivatives
substituted oxazolopyrimidine
substituted
oxazolopyrimidine derivatives
formula
Prior art date
Application number
MX2012007835A
Other languages
English (en)
Inventor
Matthias Schaefer
Dieter Kadereit
Stephanie Hachtel
Axel Dietrich
Thomas Huebschle
Andreas Gille
Katrin Hiss
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2012007835A publication Critical patent/MX2012007835A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de oxazolopirimidina de la fórmula I, (ver fórmula (I)) en la que A, R1, R2 y R3 se definen como se ha indicado en las reivindicaciones. Los compuestos de la fórmula I son adecuados, por ejemplo, para la cicatrización de las heridas.
MX2012007835A 2010-01-13 2011-01-12 Derivados de oxazolopirimidina sustituida en 2, 5,7. MX2012007835A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10305035 2010-01-13
PCT/EP2011/050295 WO2011086075A1 (de) 2010-01-13 2011-01-12 2,5,7-substituierte oxazolopyrimidinderivate

Publications (1)

Publication Number Publication Date
MX2012007835A true MX2012007835A (es) 2012-07-30

Family

ID=41820512

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007835A MX2012007835A (es) 2010-01-13 2011-01-12 Derivados de oxazolopirimidina sustituida en 2, 5,7.

Country Status (20)

Country Link
US (1) US8785439B2 (es)
EP (1) EP2523961B1 (es)
JP (1) JP5844276B2 (es)
KR (1) KR101759126B1 (es)
CN (1) CN102791716B (es)
AR (1) AR079980A1 (es)
AU (1) AU2011206611B2 (es)
BR (1) BR112012017393A2 (es)
CA (1) CA2791445C (es)
DK (1) DK2523961T3 (es)
ES (1) ES2448645T3 (es)
IL (1) IL220707A (es)
MX (1) MX2012007835A (es)
MY (1) MY156525A (es)
PT (1) PT2523961E (es)
RU (1) RU2557246C2 (es)
SG (1) SG183101A1 (es)
TW (1) TWI485153B (es)
UY (1) UY33176A (es)
WO (1) WO2011086075A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102834399B (zh) * 2010-01-14 2015-04-22 赛诺菲 具有2,5-取代的*唑并嘧啶环的杂环羧酸衍生物
CA2784560C (en) * 2010-01-14 2017-12-05 Sanofi Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
CN102834400B (zh) 2010-01-14 2015-06-10 赛诺菲 2,5-取代的*唑并嘧啶衍生物
US9321787B2 (en) 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
RU2022103033A (ru) 2015-07-02 2022-04-01 ХОРАЙЗОН ОРФАН ЭлЭлСи Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
CN118598916A (zh) 2020-02-18 2024-09-06 吉利德科学公司 抗病毒化合物
CN117120444A (zh) 2021-04-16 2023-11-24 吉利德科学公司 使用酰胺制备卡巴核苷的方法
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05010802A (es) 2003-04-25 2005-12-14 Univ Cardiff Compuestos heterociclicos para el uso en el tratamiento de infecciones virales.
AR044402A1 (es) * 2003-05-19 2005-09-14 Irm Llc Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
FR2865208B1 (fr) * 2004-01-16 2009-01-16 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique
US7855193B2 (en) * 2005-11-23 2010-12-21 Epix Pharmaceuticals, Inc. S1P receptor modulating compounds and use thereof
EP1900729A1 (en) * 2006-09-15 2008-03-19 Novartis AG Benzoxazoles and oxazolopyridines being useful as Janus kinases inhibitors
JP5191497B2 (ja) * 2007-03-21 2013-05-08 エピックス ファーマシューティカルズ，インコーポレイテッド Ｓ１ｐ受容体調節化合物およびその使用
TW201000099A (en) * 2008-06-20 2010-01-01 Amgen Inc S1P1 receptor agonists and use thereof
KR20110042286A (ko) 2008-07-15 2011-04-26 사노피-아벤티스 Ｅｄｇ－１ 수용체 작용제로서의 옥사졸로피리미딘
UY33177A (es) 2010-01-13 2011-08-31 Sanofi Aventis Derivados de ácido carboxílico que comprenden un anillo de oxazolopirimidina 2, 5, 7-sustituido
TWI517851B (zh) 2010-01-13 2016-01-21 賽諾菲阿凡提斯公司 含２，５，７－經取代唑并嘧啶環之雜環羧酸衍生物
CN102834400B (zh) 2010-01-14 2015-06-10 赛诺菲 2,5-取代的*唑并嘧啶衍生物
CN102834399B (zh) 2010-01-14 2015-04-22 赛诺菲 具有2,5-取代的*唑并嘧啶环的杂环羧酸衍生物
CA2784560C (en) 2010-01-14 2017-12-05 Sanofi Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

Also Published As

Publication number Publication date
US20130137685A1 (en) 2013-05-30
ES2448645T3 (es) 2014-03-14
HK1178884A1 (en) 2013-09-19
RU2557246C2 (ru) 2015-07-20
PT2523961E (pt) 2014-03-20
KR101759126B1 (ko) 2017-07-18
SG183101A1 (en) 2012-09-27
RU2012134349A (ru) 2014-02-20
WO2011086075A1 (de) 2011-07-21
TW201141873A (en) 2011-12-01
CN102791716B (zh) 2016-05-11
US8785439B2 (en) 2014-07-22
MY156525A (en) 2016-02-26
JP2013517238A (ja) 2013-05-16
EP2523961B1 (de) 2013-12-18
AR079980A1 (es) 2012-03-07
AU2011206611A1 (en) 2012-08-02
TWI485153B (zh) 2015-05-21
DK2523961T3 (en) 2014-03-24
AU2011206611B2 (en) 2015-03-05
CN102791716A (zh) 2012-11-21
IL220707A (en) 2015-02-26
BR112012017393A2 (pt) 2017-12-12
JP5844276B2 (ja) 2016-01-13
KR20120115544A (ko) 2012-10-18
EP2523961A1 (de) 2012-11-21
CA2791445A1 (en) 2011-07-21
UY33176A (es) 2011-08-31
IL220707A0 (en) 2012-08-30
CA2791445C (en) 2017-08-29

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