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MX2012007410A - Compuestos antivirales novedosos. - Google Patents

Compuestos antivirales novedosos.

Info

Publication number
MX2012007410A
MX2012007410A MX2012007410A MX2012007410A MX2012007410A MX 2012007410 A MX2012007410 A MX 2012007410A MX 2012007410 A MX2012007410 A MX 2012007410A MX 2012007410 A MX2012007410 A MX 2012007410A MX 2012007410 A MX2012007410 A MX 2012007410A
Authority
MX
Mexico
Prior art keywords
compounds
relates
treatment
viral infections
antiviral activity
Prior art date
Application number
MX2012007410A
Other languages
English (en)
Inventor
Patrick Chaltin
Frauke Christ
Zeger Debyser
Marc De Maeyer
Arnaud Marchand
Gunter Carlens
Damien Marchand
Arnout Voet
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0922520A external-priority patent/GB0922520D0/en
Priority claimed from GBGB1001204.5A external-priority patent/GB201001204D0/en
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2012007410A publication Critical patent/MX2012007410A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (A) como se definen en la presente que tienen actividad antiviral, de modo más específico propiedades inhibidoras de replicación de VIH (Virus de Inmunodeficiencia Humano). La invención se refiere también a composiciones farmacéuticas que comprenden una cantidad efectiva de dichos compuestos como ingredientes activos. Esta invención se refiere además al uso de dichos compuestos como medicinas o en la elaboración de un medicamento útil para el tratamiento de animales que padecen de infecciones virales, en particular infección por VIH. Esta invención se refiere además a métodos para el tratamiento de infecciones virales en animales mediante la administración de una cantidad terapéutica de dichos compuestos, opcionalmente combinados con uno o más de otros fármacos que tienen actividad antiviral (Ver Formula).
MX2012007410A 2009-12-23 2010-12-20 Compuestos antivirales novedosos. MX2012007410A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0922520A GB0922520D0 (en) 2009-12-23 2009-12-23 Novel antiviral compounds
GBGB1001204.5A GB201001204D0 (en) 2010-01-26 2010-01-26 Novel antiviral compounds
PCT/EP2010/070306 WO2011076765A1 (en) 2009-12-23 2010-12-20 Novel antiviral compounds

Publications (1)

Publication Number Publication Date
MX2012007410A true MX2012007410A (es) 2012-07-17

Family

ID=44246874

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007410A MX2012007410A (es) 2009-12-23 2010-12-20 Compuestos antivirales novedosos.

Country Status (13)

Country Link
US (1) US20120316161A1 (es)
EP (1) EP2516008B1 (es)
JP (1) JP2013515692A (es)
KR (1) KR101483834B1 (es)
CN (1) CN102770181B (es)
AU (1) AU2010334958B2 (es)
CA (1) CA2781780C (es)
ES (1) ES2475970T3 (es)
IL (1) IL219965A0 (es)
MX (1) MX2012007410A (es)
PT (1) PT2516008E (es)
SG (2) SG181423A1 (es)
WO (1) WO2011076765A1 (es)

Families Citing this family (58)

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GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
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US8633200B2 (en) 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP2640705A2 (en) 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
CN105330675A (zh) 2010-11-15 2016-02-17 Viiv保健英国有限公司 Hiv复制的抑制剂
ES2742261T3 (es) 2011-04-15 2020-02-13 Hivih Inhibidores de la replicación viral, su proceso de preparación y sus usos terapéuticos
EP3181555B1 (en) 2011-04-21 2018-11-28 Gilead Sciences, Inc. Benzothiazole compounds and their pharmaceutical use
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP2772480B2 (en) 2011-10-25 2020-12-09 Shionogi & Co., Ltd. Hiv replication inhibitor
EP2794611B1 (en) * 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
US8629276B2 (en) 2012-02-15 2014-01-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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EP3103455A4 (en) * 2014-02-07 2017-10-04 National University Corporation Tokyo Medical and Dental University Myogenesis accelerator, amyotrophy suppressor, medicinal composition, and taz activator
US9944656B2 (en) 2014-02-12 2018-04-17 VIIV Healthcare UK (No.5) Limited Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication
EP3152211A1 (en) 2014-02-12 2017-04-12 ViiV Healthcare UK (No.5) Limited Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9409922B2 (en) 2014-02-18 2016-08-09 Bristol-Myers Squibb Company Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
US9834566B2 (en) 2014-02-18 2017-12-05 VIIV Healthcare UK (No.5) Limited Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
EP3116879A1 (en) 2014-02-18 2017-01-18 VIIV Healthcare UK (No.5) Limited Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
US9273067B2 (en) 2014-02-19 2016-03-01 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
PT3107913T (pt) 2014-02-19 2018-09-28 Viiv Healthcare Uk No 5 Ltd Inibidores da replicação do vírus da imunodeficiência humana
US9193720B2 (en) 2014-02-20 2015-11-24 Bristol-Myers Squibb Company Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
PT3116880T (pt) 2014-02-20 2018-05-10 Viiv Healthcare Uk No 5 Ltd Macrociclos de ácido piridin-3-il acético como inibidores da replicação do vírus da imunodeficiência humana
EP3144311A4 (en) 2014-05-16 2018-01-03 Shionogi & Co., Ltd. Tricyclic heterocyclic derivative having hiv replication-inhibiting effect
KR101692478B1 (ko) 2014-07-10 2017-01-05 계명대학교 산학협력단 Ｓｙ­０２９를 유효성분으로 함유하는 항바이러스 조성물
MX2017015256A (es) 2015-05-29 2018-02-19 Shionogi & Co Derivados triciclicos que contienen nitrogeno que tienen actividad inhibidora de la replicacion del virus de inmunodeficiencia adquirida (vih).
BR112018000177A2 (pt) 2015-07-06 2018-09-04 Viiv Healthcare Uk No 5 Ltd composto, composição, e, método para tratar a infecção pelo hiv.
AU2016290151A1 (en) 2015-07-08 2018-01-18 VIIV Healthcare UK (No.5) Limited Pyridin-3-YL acetic acid derivatives as inhibitors of human immunodeficiency virus replication
RU2018103032A (ru) 2015-07-09 2019-08-09 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД Производные пиридин-3-ил-уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека
RU2018103031A (ru) 2015-07-09 2019-08-09 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД Производные пиридин-3-ил уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека
CN108137532A (zh) 2015-08-07 2018-06-08 Viiv保健英国第五有限公司 作为人免疫缺陷病毒复制的抑制剂的吡啶-3-基乙酸衍生物
AU2016305338A1 (en) 2015-08-10 2018-03-01 VIIV Healthcare UK (No.5) Limited Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
TWI657086B (zh) 2015-08-11 2019-04-21 英商Viiv醫療保健英國(No.5)有限公司 做為人類免疫缺陷病毒複製抑制劑之５－（ｎ－苯甲基四氫異喹啉－６－基）吡啶－３－基乙酸衍生物
TW201718537A (zh) 2015-08-12 2017-06-01 Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物
US10214516B2 (en) 2015-08-12 2019-02-26 VIIV Healthcare UK (No.5) Limited 5-(N-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
EP3334723B1 (en) 2015-08-12 2019-09-18 VIIV Healthcare UK (No.5) Limited 5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
JP2018523695A (ja) 2015-08-20 2018-08-23 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
US10407410B2 (en) 2016-05-11 2019-09-10 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
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US20190152957A1 (en) 2016-05-11 2019-05-23 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2018127800A1 (en) 2017-01-03 2018-07-12 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
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Also Published As

Publication number Publication date
CN102770181B (zh) 2015-08-12
EP2516008A1 (en) 2012-10-31
IL219965A0 (en) 2012-07-31
WO2011076765A1 (en) 2011-06-30
AU2010334958B2 (en) 2015-02-05
CA2781780C (en) 2015-02-17
EP2516008B1 (en) 2014-04-16
KR20120106869A (ko) 2012-09-26
JP2013515692A (ja) 2013-05-09
ES2475970T3 (es) 2014-07-11
CN102770181A (zh) 2012-11-07
SG10201408512RA (en) 2015-02-27
CA2781780A1 (en) 2011-06-30
SG181423A1 (en) 2012-07-30
PT2516008E (pt) 2014-07-16
AU2010334958A1 (en) 2012-06-07
US20120316161A1 (en) 2012-12-13
KR101483834B1 (ko) 2015-01-16

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