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MX2012005283A - Proceso para la preparacion de calcobutrol. - Google Patents

Proceso para la preparacion de calcobutrol.

Info

Publication number
MX2012005283A
MX2012005283A MX2012005283A MX2012005283A MX2012005283A MX 2012005283 A MX2012005283 A MX 2012005283A MX 2012005283 A MX2012005283 A MX 2012005283A MX 2012005283 A MX2012005283 A MX 2012005283A MX 2012005283 A MX2012005283 A MX 2012005283A
Authority
MX
Mexico
Prior art keywords
calcobutrol
preparation
concerns
complex
tetraazacycl
Prior art date
Application number
MX2012005283A
Other languages
English (en)
Inventor
Johannes Platzek
Wilhelm Trentmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43297060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012005283(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2012005283A publication Critical patent/MX2012005283A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/04—Calcium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Proceso para la preparación del complejo con calcio del ácido O-(2,3- Dihidroxi-1 -(hidroximetil) propil)-1 14, 7,1 O-tetraazaciclodecano-1, 4,7-triacético, que también se conoce como Calcobutrol, comenzando a partir del complejo con gadolinio (Gadobutrol) puro. Además, Calcobutrol con un nivel de pureza desconocido hasta el presente.
MX2012005283A 2009-11-04 2010-11-02 Proceso para la preparacion de calcobutrol. MX2012005283A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009053171A DE102009053171B4 (de) 2009-11-04 2009-11-04 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
PCT/EP2010/066655 WO2011054827A1 (en) 2009-11-04 2010-11-02 Process for the preparation of calcobutrol

Publications (1)

Publication Number Publication Date
MX2012005283A true MX2012005283A (es) 2012-10-05

Family

ID=43297060

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005283A MX2012005283A (es) 2009-11-04 2010-11-02 Proceso para la preparacion de calcobutrol.

Country Status (35)

Country Link
US (1) US9447053B2 (es)
EP (2) EP2496562B1 (es)
JP (1) JP5733800B2 (es)
KR (3) KR20120093388A (es)
CN (1) CN102164901B (es)
AR (1) AR078906A1 (es)
AU (1) AU2010317166C1 (es)
BR (1) BR112012010320B1 (es)
CA (1) CA2777314C (es)
CL (1) CL2012001172A1 (es)
CO (1) CO6551758A2 (es)
CR (1) CR20120235A (es)
CU (1) CU24105B1 (es)
CY (1) CY1115051T1 (es)
DE (1) DE102009053171B4 (es)
DK (1) DK2496562T3 (es)
DO (1) DOP2012000126A (es)
EA (2) EA201300789A1 (es)
EC (1) ECSP12011866A (es)
ES (1) ES2462970T3 (es)
HR (1) HRP20140399T1 (es)
IL (1) IL219012A0 (es)
MX (1) MX2012005283A (es)
MY (1) MY158421A (es)
NZ (2) NZ599705A (es)
PE (1) PE20130224A1 (es)
PH (1) PH12012500891A1 (es)
PL (1) PL2496562T3 (es)
PT (1) PT2496562E (es)
RS (1) RS53287B (es)
SI (1) SI2496562T1 (es)
TW (1) TWI473794B (es)
UY (1) UY33002A (es)
WO (1) WO2011054827A1 (es)
ZA (1) ZA201202504B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2780599T3 (es) 2011-04-21 2020-08-26 Bayer Ip Gmbh Preparación de gadobutrol de alta pureza
EP2786768A1 (en) 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
KR101693400B1 (ko) 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101646211B1 (ko) * 2014-11-12 2016-08-05 (주)디아이테크 자기공명영상용 조영제의 제조방법
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN105037288B (zh) * 2015-07-23 2017-11-03 上海现代制药海门有限公司 一种布醇的制备方法
CN106620726B (zh) * 2015-10-29 2020-10-02 山东威智百科药业有限公司 一种钆布醇注射液及其制备方法
CN106187930B (zh) * 2016-07-12 2018-10-19 嘉实（湖南）医药科技有限公司 高纯度考布曲钙的制备方法
HUE050553T2 (hu) * 2016-09-27 2020-12-28 Bayer Pharma AG Eljárás A módosulatú kalkobutrol kristályos alakjának elõállítására
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN109384737A (zh) * 2017-08-04 2019-02-26 天津科伦药物研究有限公司 一种四氮杂环钇络合物及其制备方法和应用
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR20190088793A (ko) * 2018-01-19 2019-07-29 주식회사 엔지켐생명과학 칼코부트롤의 제조방법
EP3820853A4 (en) 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-(10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECANE-1 ACID ,4,7-TRIYL) TRIACETIC AND ITS COMPLEXES
WO2020084504A1 (en) * 2018-10-24 2020-04-30 Biophore India Pharmaceuticals Pvt. Ltd Novel process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetra azacyclododecane-1,4,7-triyl) triacetic acid and it's complexes with paramagnetic metal ions
AU2019382881B2 (en) * 2018-11-23 2025-06-12 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
US11667601B2 (en) 2019-12-20 2023-06-06 Bracco Imaging S.P.A. Calcium BOPTA complex
KR20210112910A (ko) 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN114573522A (zh) * 2020-11-30 2022-06-03 江苏恒瑞医药股份有限公司 一种考布曲钙的新晶型及其制备方法
CN115779105B (zh) * 2022-11-17 2025-05-27 华润双鹤药业股份有限公司 一种钆布醇注射液及其制备方法
CN119143689B (zh) * 2024-11-15 2025-05-30 苏州美诺医药科技有限公司 考布曲钙和其中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625417C2 (de) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4009119A1 (de) 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IE910955A1 (en) 1990-03-23 1991-09-25 Yamanouchi Europ Bv Il-6 inhibiting compositions
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
IT1275426B (it) 1995-05-16 1997-08-07 Bracco Spa Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292130B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1293778B1 (it) 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
US9016221B2 (en) * 2004-02-17 2015-04-28 University Of Florida Research Foundation, Inc. Surface topographies for non-toxic bioadhesion control
WO2011054480A1 (de) * 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran

Also Published As

Publication number Publication date
NZ599705A (en) 2014-03-28
PL2496562T3 (pl) 2014-07-31
DE102009053171B4 (de) 2011-07-21
CR20120235A (es) 2012-08-01
EA020161B9 (ru) 2018-11-30
KR20110086885A (ko) 2011-08-01
TW201139387A (en) 2011-11-16
CL2012001172A1 (es) 2012-09-14
DK2496562T3 (da) 2014-05-12
EA020161B1 (ru) 2014-09-30
TWI473794B (zh) 2015-02-21
PT2496562E (pt) 2014-05-13
AU2010317166B2 (en) 2014-11-27
EP2599777A1 (en) 2013-06-05
CY1115051T1 (el) 2016-12-14
DOP2012000126A (es) 2012-08-15
NZ612449A (en) 2015-01-30
CA2777314C (en) 2017-09-12
EP2496562B1 (en) 2014-02-12
BR112012010320A2 (pt) 2016-03-29
AU2010317166C1 (en) 2019-02-28
CU24105B1 (es) 2015-07-30
IL219012A0 (en) 2012-06-28
ECSP12011866A (es) 2012-07-31
JP5733800B2 (ja) 2015-06-10
KR20110058746A (ko) 2011-06-01
CA2777314E (en) 2011-05-12
ES2462970T3 (es) 2014-05-27
AU2010317166A1 (en) 2012-05-03
EA201300789A1 (ru) 2013-12-30
HRP20140399T1 (hr) 2014-06-06
CN102164901B (zh) 2015-03-11
HK1161237A1 (en) 2012-08-24
KR101057939B1 (ko) 2011-08-18
PH12012500891A1 (en) 2012-11-12
KR101251210B1 (ko) 2013-04-08
CA2777314A1 (en) 2011-05-12
MY158421A (en) 2016-10-14
UY33002A (es) 2011-06-30
CU20120072A7 (es) 2012-10-15
DE102009053171A1 (de) 2011-05-05
RS53287B (sr) 2014-08-29
EA201200652A1 (ru) 2012-12-28
US9447053B2 (en) 2016-09-20
PE20130224A1 (es) 2013-03-06
JP2013510117A (ja) 2013-03-21
SI2496562T1 (sl) 2014-06-30
WO2011054827A1 (en) 2011-05-12
AR078906A1 (es) 2011-12-14
ZA201202504B (en) 2013-06-26
CO6551758A2 (es) 2012-10-31
US20120309962A1 (en) 2012-12-06
EP2496562A1 (en) 2012-09-12
KR20120093388A (ko) 2012-08-22
BR112012010320B1 (pt) 2019-05-14
CN102164901A (zh) 2011-08-24

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Owner name: BAYER INTELLECTUAL PROPERTY GMBH

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