MX2012004954A

MX2012004954A - Solid dispersion of rifaximin.

Info

Publication number: MX2012004954A
Application number: MX2012004954A
Authority: MX
Inventors: Harshal Anil Jahagirdar; Shirishkumar Kulkarni; Satish Kumar Dalal
Original assignee: Lupin Ltd
Priority date: 2009-10-27
Filing date: 2010-10-27
Publication date: 2012-09-07
Also published as: CL2012001080A1; WO2011051971A2; US20140221414A1; JP2013508451A; EP2493456B1; US20250082615A1; IL219508A; US20120214833A1; CN102665693A; JP6211768B2; KR101972354B1; MX346660B; JP2016006117A; WO2011051971A3; PH12012500838A1; IL219508A0; CN113274355B; RU2012121599A; EP2493456A2; KR20200100215A

Abstract

A solid dispersion of rifaximin comprising rifaximin and pharmaceutically acceptable carrier. A pharmaceutical composition comprising the solid dispersion of rifaximin.

Description

SOLID DISPERSION OF RIFAXIMIN Field of the invention The present invention relates to the solid dispersion of rifaximin, which increases the solubility of rifaximin and improves the gastrointestinal availability, and preparation process of such solid dispersion. It also relates to pharmaceutical compositions comprising a solid dispersion of rifaximin.

Background of the Invention Antibiotic rifaximin was originally disclosed in Italian Patent No. 1154655. The US patent. related No. 4,341,785 for archi et al. describes imidazo-rifamycin derivatives having antibacterial utility, and the related process for their preparation. The patent of E.U. '785 also discloses an antibacterial pharmaceutical composition and a method for using it to treat antibacterial diseases of the gastrointestinal tract (GIT).

Rifaximin is essentially a non-absorbable, non-systemic, semi-synthetic antibiotic related to rifamycin. The antimicrobial spectrum includes more gram-positive and gram-negative bacteria, and both aerobic and anaerobic. Rifaximin is approved in some countries for the treatment of pathologies whose etiology is partly or totally due to acute and chronic intestinal infections suffered by gram-positive and gram-negative bacteria, with syndromes of diarrhea, alteration of the flora intestinal microbial, episodes like summer diarrhea, traveler's diarrhea and enterocolitis, pre-and post-surgery of the prophylaxis of infectious complications in gastrointestinal surgery, and hyperammonemia therapy as adjuvant.

Rifaximin is currently sold as 200 mg tablets for traveler's diarrhea, under the brand name "Xifaxan®". The advantages of rifaximin for the treatment of these infections are of two types: (1) web-based delivery of antibiotics, and (2) improved tolerability compared to other treatments.

Rifaximin is practically insoluble in water and is practically undissolved in the gastrointestinal tract (GIT). The relative insolubility of rifaximin also leads to its negligible systemic absorption. Less than 0.5% of the drug is absorbed into the bloodstream when taken orally.

Rifaximin has been known to be effective in treating infections that localize to the intestine and is not known to be suitable for the treatment of systemic infections caused by invading organisms. By increasing the solubility of rifaximin, the dose can be significantly reduced thereby making it compatible with more patients. There is a need for the development of rifaximin in a form that will increase its solubility and improve gastrointestinal availability.

WO 2010067072 by Ghagare et al. describes a complex of rifaximin to increase the solubility of rifaximin in this way increases the bioavailability of rifaximin in the body.

We have prepared the solid dispersion of rifaximin, which, surprisingly, increases the solubility and gastrointestinal availability of rifaximin.

Brief Description of the Invention The object of the invention is to provide a solid dispersion of rifaximin. The solid dispersion of rifaximin comprises rifaximin and pharmaceutically acceptable carrier.

In another embodiment, the solid dispersion of rifaximin increases the solubility of rifaximin relative to an equivalent amount of rifaximin.

Another embodiment refers to the solid dispersion of rifaximin, in which the solubility of rifaximin is increased by more than 30%.

In another embodiment, the solid dispersion of rifaximin increases the gastrointestinal availability of rifaximin relative to an equivalent amount of rifaximin.

Another embodiment refers to the solid dispersion of rifaximin, in which the solubility of rifaximin in the solid dispersion is increased relative to an equivalent amount of rifaximin, while maintaining the relative permeability equivalent to an equivalent amount of rifaximin.

In another embodiment, the solid dispersion of rifaximin increases both the solubility and the gastrointestinal availability of rifaximin.

Another modality is related to the process to make a solid dispersion of rifaximin.

Another embodiment refers to the pharmaceutical composition comprising a solid dispersion of rifaximin.

Another embodiment relates to the pharmaceutical composition comprising a stable solid dispersion comprising a therapeutically effective amount of rifaximin, which provides a higher solubility of rifaximin and improved gastrointestinal availability (TGI) relative to an equivalent dose of rifaximin in a commercially available tablet, or for an equivalent dose of rifaximin in a simple solution such as in water or normal saline, which is ingested orally.

Another embodiment refers to a method for treating and / or preventing a microbial infection, which comprises administering to a patient in need thereof a therapeutically effective amount of solid dispersion of rifaximin.

Another embodiment refers to the pharmaceutical composition comprising a stable solid dispersion comprising a therapeutically effective amount of rifaximin, administered at various frequencies or once a day to a patient suffering from traveler's diarrhea, hepatic encephalopathy, diarrhea, infectious diarrhea, disease diverticular, antibacterial prophylactic before colon surgery, irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diarrhea associated with Clostridium difficile, small intestinal bacterial proliferation, prophylaxis of traveler's diarrhea, dysentery, pouchitis, ulcer disease peptic, surgical prophylaxis and gastric dyspepsia in a dose, at a frequency and for a sufficient time to provide a beneficial effect for the patient.

However, another form of embodiment refers to the pharmaceutical composition comprising a stable solid dispersion comprising a therapeutically effective amount of rifaximin, administered in conjunction with a second pharmaceutically active agent.

Another embodiment relates to the modified release pharmaceutical composition comprising a stable solid dispersion comprising a therapeutically effective amount of rifaximin, administered in conjunction with a second pharmaceutically active agent.

Detailed description of the invention The present invention relates to the solid dispersion of rifaximin, which comprises rifaximin and the pharmaceutically acceptable carrier, which increases the solubility and the gastrointestinal availability of rifaximin, and the process of preparing such a solid dispersion.

It also relates to the pharmaceutical composition comprising a solid dispersion of rifaximin comprising a therapeutically effective amount of rifaximin, which increases the solubility of rifaximin and improves gastrointestinal availability.

Technologies to increase the solubility of the drug include chemical modification as a prodrug or salt formation, physical modification as solid dispersions, nanocrystals and nanoparticles, co-crystals and charge in porous structures, alteration of the composition of solvents, such as pH adjustments, co-solvents and wetting agents, transport systems, such as cyclodextrins, inclusion complexes, liposomes, polymeric micelles, emulsions, microemulsions and amphiphilic polymers, dispersions of surfactants, micronization by colloid mills or mills of jet and the like.

The solids dispersion technique has often been shown to be the most commonly used technique in improving the dissolution of poorly soluble active pharmaceutical ingredients, as it is simple, economical and advantageous.

The advantages of solid dispersions are increased wettability due to dispersion in a hydrophilic carrier; reduced drug particle size and therefore greater surface area in the two-phase solid dispersions; reduced crystallinity or the creation of amorphous systems.

The solid dispersion may be in a single phase, such as substitute or interstitial crystalline solutions or amorphous solutions; or it can be a two-phase system, such as eutectic, amorphous crystalline drug carrier or amorphous drug and carrier amorphous dispersions. The solid solutions are a single phase resulting in the dispersion of two compounds themselves, at their molecular level.

Various methods of solid dispersion formation include traditional cold melting method, hot stage extrusion, melt agglomeration, meltrex®; co-precipitation, evaporation of the solvent, such as vacuum drying, plate heat drying, slow evaporation at low temperature, rotary evaporation, spray drying, lyophilization, centrifugation and drying of supercritical fluids.

Definitions : As the term is used herein, "rifaximin" refers to rifaximin base, pharmaceutically acceptable salts, polymorph (s), solvate (s), hydrate (s), enantiomer (s) thereof unless specify otherwise.

"Therapeutically effective amount" means the amount of active agent, which stops or reduces the progress of the condition to be treated or otherwise cures completely or partially or acts palliatively on the condition. A person skilled in the art can easily determine such amount by routine experimentation without undue burden.

The term "solid dispersion" means the finely dispersed distribution of one or more components, for example an active substance such as rifaximin, in a solid or semi-solid inert carrier that increases wettability and / or solubility, but also covers semi-solid dispersions. . The active principle can be present in dispersed molecular form, that is, as a solid solution, in fine dispersed crystalline form, in a glassy or dispersed amorphous phase in the form of a fine amorphous powder. Eutectic mixtures, ie the crystalline structures of active substances and carriers are also included in the definition of "solid dispersions".

"Solubility" means solubility of rifaximin in aqueous media such as water, buffer, simulated gastrointestinal fluid, gastrointestinal fluid and the like.

A "formulation" or "composition" as the term is used herein is a composition of matter that includes rifaximin and other components, such as excipients, stabilizers, dispersants, surfactants, and the like.

By "pharmaceutically acceptable" is meant a carrier composed of a material that is not biologically or otherwise undesirable.

"Administering" or "administration" refers to providing a medicinal compound to a patient in need thereof.

A "frequency" of administration refers to the frequency with the medication being administered when repeated doses are prescribed, for example, the medication may be administered daily .. "Duration" refers to the period of time during which repeated doses are administered .

"Modified release" means the drug delivery system that releases the drug at a predetermined rate, either locally or systemically, for a specified period of time. In other words, the modified release is different from immediate release. The modified release can be used interchangeably with prolonged release, programmed release, time calculated release, extended release, sustained release, controlled release, delayed release, pulsatile release and other dosage forms.

A solid dispersion of rifaximin comprises rifaximin and pharmaceutically acceptable carrier. It also comprises surfactants, emulsifiers, stabilizing agents, etc. The solvent is used in the preparation of the solid dispersion, which is to be removed. Rifaximin and the pharmaceutically acceptable carrier can be present in various proportions.

The carrier and solvent selection will depend on the chemistry of rifaximin. The most important selection criteria are the miscibility of the carriers and good stability during the dispersion process of solid manufacturing and storage on it.

Pharmaceutically acceptable carriers used to prepare a solid dispersion of rifaximin include but are not limited to urea, sugar, organic acids, polyethylene glycol, povidone, copovidone, polymethacrylates, polyvinyl acetate, cellulose derivatives, self-emulsifying carriers, poloxamer , glyceryl behenate (Compritol), Gelucire (derived from polyethylene glycol of a mono-glyceride, ie, a PEG-ilated monoglyceride), vitamin E as tocopherol, tocotrienols; polyethylene or polyoxyethylene ester of hydroxyl stearic acid such as Solutol HS, polyoxylglycerides such as labrafil, gelucire 44/14, labrasol; polyethoxylated castor oil as cremophore or any combinations thereof.

Solvents include but are not limited to water, dipolar aprotic solvent, polyethylene glycol, polyethylene glycol ether, polyethylene glycol derivative of a mono- or di-glyceride, buffers, water soluble organic solvents, organic solvents or any combination thereof.

Surfactants include, but are not limited to polyoxylglycerides such as Labrafil, Gelucire 44/14, Labrasol; polyethoxylated castor oil such as Cremophor RH40, PDA Cremophor, polysorbate 80 or HP Vitamin E TPGS and the like, or any combination thereof.

The oils include but are not limited to a medium chain triglyceride, castor oil, medium chain mono-glyceride, medium chain di-glyceride, an edible vegetable oil such as peanut oil, cottonseed oil, or oil. of soybeans, or any combination thereof. Alternatively, the oil may be other than a glyceride, for example, the oil may be a hydrocarbon oil or a silicone oil and the like or any combination thereof.

Emulsifiers include but are not limited to lipids and phospholipids such as lecithin. The lecithin can be a lecithin of high phosphatidylcholine content, low phosphatidylcholine content lecithin and the like or any combination thereof.

Stabilizing agents include, but are not limited to antioxidants, alkalizing agents, pH modifiers, substances that prevent crystallization or any combinations thereof.

The solid dispersion of rifaximin comprises rifaximin from about 0.1% to 90% by weight of the total weight of the solid dispersion. The therapeutic dose varies according to the body weight and the acuity of the pathology; a daily dose between up to 2400 mg, administered in a single dose or divided into 2 or 3 or more doses.

The above examples are illustrative embodiments of the invention and are merely exemplary. A person skilled in the art can make variations and modifications without deviating from the object and scope of the invention. It is intended that all these modifications and variations be included within the scope of the invention.

The above examples are prepared by the following methods.

Example 1: Solid dispersion by melting Process : 1. Sift all the ingredients through the appropriate sieve. 2. Melt the heavy amount of povidone 3. Add rifaximin to the upper melted portion of povidone with agitation. 4. Allow the dough to cool to room temperature, then grind and pass through the desired sieve.

Examples 2: Solid dispersion by the solvent evaporation technique Process : 1. Sift all the ingredients through the appropriate sieve. 2. Dissolve rifaximin, povidone and poloxamer in alcohol with shaking. 3. Evaporate the previous mixture. 4. Scrap the dough above mill and then go through the desired sieve.

Examples 3: Solid dispersion by solvent evaporation technique Process : 1. Sift all the ingredients through the appropriate sieve 2. Dissolve rifaximin and povidone in alcohol with shaking. 3. Evaporate the previous mixture. 4. Discard the dough above the mill and then pass through the desired sieve.

Example: Solid dispersion by hot melt extrusion technique using water soluble polymers Process : 1. Sift all the ingredients through the appropriate sieve. 2. Mix all the sieved materials uniformly. 3. Add the above mixture in a hot melt extruder and collect the extruded material. 4. Grind the previous extrudate and pass through the desired sieve.

Example 5: Solid dispersion by the hot melt extrusion technique by the use of water soluble polymers and plasticizer Process : 1. Sift all the ingredients through the appropriate sieve. 2. Mix all the sieved materials uniformly. 3. Add the above mixture in a hot melt extruder and collect the extruded material. 4. Grind the previous extrudate and pass through the desired sieve.

Example 6: Solid dispersion by the technique of hot melt extrusion by using water soluble polymers and surfactant Process : 1. Sift all the ingredients through the appropriate sieve. 2. Mix all the sieved materials uniformly. 3. Add the above mixture in a hot melt extruder and collect the extruded material. 4. Grind the previous extrudate and pass through the desired sieve.

Example 7: Solid dispersion by the use of the co-precipitation technique.

Process : 1. Sift all the ingredients through the appropriate sieve. 2. Dissolve heavy amount of rifaximin, povidone and Span 20 in alcohol with shaking, 3. Add water to the previous solution with agitation to form a precipitate, 4. Dry the precipitate, mill and pass through the desired sieve.

Example 8: Solid dispersion by the use of solvent evaporation technique Process : 1. Sift all the ingredients through the appropriate sieve. 2. Dissolve heavy amount of rifaximin and polyethylene glycol in alcohol with stirring. 3. Evaporate the above mixtures by using the rotary evaporator. 4. Discard the previous dough then grind and pass through the desired sieve.

The solid dispersion of rifaximin provides greater solubility of rifaximin and improves gastrointestinal (GIT) availability relative to an equivalent dose of rifaximin in a commercially available tablet or dosage form, or an equivalent dose of rifaximin in a single solution as in water or normal saline or simulated gastrointestinal fluid or buffer, which is ingested orally. The increase in solubility is more than 30%.

Another modality relates to various methods for scanning and analyzing methods and preparations that aim to improve the dissolution of poorly soluble drugs. These methods of analysis include dissolution studies, saturation solubility studies, wettability studies, permeation studies, X-ray diffraction studies, etc.

The solubility study reveals that the solubility of pure rifaximin in the pH 6.8 Tris Phosphate buffer and in purified water is 0.001 mg / ml and less than 10 g / ml, respectively, while the solubility of the solid dispersion prepared by the Use of rifaximin, polaxamer 188 and povidone (1: 1: 2) in buffer pH 6.8 Tris Phosphate and purified water is 0.23 mg / ml and 0.38 mg / ml, respectively. Likewise, the solubility of the solid dispersion prepared by the use of rifaximin and povidone (1: 3) in phosphate buffer pH 6.8 Tris and purified water is 0.35 mg / ml and 0.38 mg / ml, respectively. Therefore, there is an increase in the solubility of the solid dispersion of rifaximin which leads to say improved gastrointestinal availability without increase in systemic absorption which is evident from the cell penetration study.

Study of permeability for rifaximin and the solid dispersion of rifaximin using MDCK cells (Canine Kidney Mardin Oarby cells) Place? Μ ???? ßG of the final concentration of rifaximin and solid dispersion of rifaximin in the apical part of transwell plates grown with MDCK cells. Three will be used per sample. The plates were placed in agitation water bath at 37 ° C for 2 hours. Take 20μ1 of apical and ??? μ? from a basolateral side of the sample processing at 0 and 180 minutes. The Yellow Lucifer is used as a marker to see the integrity of the monolayer of the cells. Propronalol is used as a marker of permeability.

The integrity of MDCK cells was found to be adequate adapted by Yellow Lucifer. The relative area in apical being 100%, even after 2 hours. No detectable amount of rifaximin was found on the basolateral side of the transwell, reflecting toward no apparent permeability (since the baseline value is 0, we could not calculate the Assistance to the Palestinian People through equations).

The solid dispersion and compositions containing solid dispersion of rifaximin are advantageous as rifaximin is a locally-acting antibiotic, whereby higher intestinal levels can be achieved. In addition, the dose of rifaximin generally used for the treatment of different pathogenic diseases may be reduced, as the minimum inhibitory concentration (in vitro) of rifaximin for various organisms is much lower than the concentration of rifaximin in faeces. After oral administration of 400 mg of 14C-Rifaximin to healthy volunteers, approximately 97% of the dose was recovered in the faeces, almost completely in unaltered form, and 0.32% was recovered in the urine.

The minimum inhibitory concentration (MIC) is defined as the lowest concentration of rifaximin that completely inhibits visible growth (a fine, barely visible haze or a single colony will be taken into account).

Table 1: MIC90 of rifaximin for selected enteric pathogens.

Pathogen No. of strains MlCsa ug / ml Campilobacter 9 32 jejuni 54 12 8 Clostridium 93 12 8 difficile 56 12 8 Escherichia coli Enteroadded 75 32 Enterotoxigenic 97 32 Helicobacter 40 4 (MICSÍI) pylori Species of 46 64 Salmonella Species of 36 64 Shigella Vibrio cholerae 403 4 Yersinia 74 16 enterocolicica 0tro3 21 4 The dose of rifaximin in the form of solid dispersion can be reduced as its solubility increases. A quantitative method (diffusion technique) is used to evaluate the antimicrobial effect of solid dispersion of rifaximin with respect to pure rifaximin. The measurement of diameters of the zone calculates the sensitivity of the bacteria to the antimicrobial compounds.

Determination of the anti-microbial activity of rifaximin and solid dispersion of rifaximin by the cup plate method or well plate method: Prepare a nutrient agar medium in distilled water and sterilize this medium in an autoclave at 121 ° C for 15 min. Transfer this medium aseptically in sterile petriplate, allow the media to consolidate for a few minutes. After solidification, add microorganism test ie E. Coli (100 μ?) On each plate and spread this culture with the aid of crosshead. Prepare the well of the plate with the help of the drill bit. Add the test sample (rifaximin and solid dispersion of rifaximin) 200 μ? in each well aseptically; incubate this plate in an incubator at 37 ° C for 24 hours and then observe the zone of inhibition around the well.

Rifaximin after 24 hours shows a very insignificant area of inhibition where rifaximin dispersion as a solid with povidone (1: 3) and rifaximin solid dispersion with poloxamer and povidone (1: 1: 2) shows mm in the area of inhibition zone of 15 mm and 10 respectively.

The solid dispersion of the rifaximin of the invention can be formulated in solid, semi-solid or liquid preparations together with a pharmaceutically acceptable excipient (s), in the form of tablets (individual tablets in layers, multilayer tablets, mini tablets, bioadhesive tablets, tablets, matrix tablets, tablet within a tablet, mucoadhesive tablets, modified-release tablets, pulsatile-release tablets, timed-release tablets, delayed-release, controlled-release, sustained-release and sustained-release tablets), tablets, pearls, granules, sustained release compositions, pills, troches, hard and soft capsules or soft filled liquid gelatin capsules, microcapsules, minitablets, tablets and microspheres, matrix compositions, osmotic compositions, compositions, bioadhesives, powder / tablets / granules for suspension, powders, solutions, suspensions, sachets or emulsions, and the like.

The composition comprising a solid dispersion of rifaximin may comprise pharmaceutically acceptable excipients include but are not limited to binders, diluents, lubricants, glidants and surface active agents.

The amount of additive used will depend on the amount of active agent to be used. An excipient can perform more than one function.

Binders include, but are not limited to, starches such as potato starch, wheat starch, corn starch; microcrystalline cellulose; celluloses such as hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropylmethylcellulose (HPMC), ethyl cellulose, carboxymethyl cellulose sodium; natural gums such as gum arabic, alginic acid, guar gum; liquid glucose, dextrin, povidone, syrup, polyethylene oxide, polyvinylpyrrolidone, poly-N-vinyl amide, polyethylene glycol, gelatin, polypropylene glycol, tragacanth, combinations of and other materials known to one of ordinary skill in the art and mixtures thereof .

Fillers or diluents include, but are not limited to, confectionery sugar, compressible sugar, dextrins, dextrin, dextrose, fructose, lactitol, mannitol, sucrose, starch, lactose, xylitol, sorbitol, talcum, microcrystalline cellulose, calcium carbonate, phosphate Calcium dibasic or tribasic, calcium sulfate, and the like can be used.

Lubricants may be selected from, but are not limited to, those conventionally known in the art, such as magnesium, aluminum or calcium or zinc stearate, polyethylene glycol, glyceryl behenate, mineral oil, sodium stearyl fumarate, stearic acid, oil hydrogenated vegetable and talcum.

Glidants include, but are not limited to silicon dioxide, magnesium trisilicate, powdered cellulose, starch, talc and tribasic calcium phosphate, calcium silicate, magnesium silicate, colloidal silicon dioxide, silicone hydrogel and other known materials for a normal technician in the field.

Compositions comprising a solid dispersion of rifaximin may optionally contain a surfactant. The preferred surfactant are copolymers composed of a hydrophobic polyoxypropylene backbone (polypropylene oxide) and polyoxyethylene (polyethylene oxide) which is well known as poloxamer. However, other surfactants can also be employed as sodium dioctyl sulfosuccinate (DSS), triethanolamine, sodium lauryl sulfate (SLS), polyoxyethylene sorbitan and poloxalkol derivatives, quaternary ammonium salts or other pharmaceutically acceptable surfactants known to ordinary a technician in the art. matter.

Another embodiment relates to pharmaceutical compositions comprising modified release of solid dispersion of rifaximin for oral use.

Another embodiment refers to various combinations of immediate release composition comprising a solid dispersion of rifaximin and the modified release composition comprising a solid dispersion of rifaximin.

The pharmaceutical dosage form comprising a solid dispersion of rifaximin may optionally have one or more coatings, such as film coating, sugar coating, enteric coating, bioadhesive coating and other coatings known in the art. These coatings aid the pharmaceutical compositions to release the drug at the desired site of action. In one example, the additional coating prevents dosing in contact with the mouth or esophagus. In another example, the additional coating remains intact until reaching the small intestine (e.g., an enteric coating). Premature exposure of a bioadhesive layer or dissolution of a pharmaceutical dosage form in the mouth can be prevented with a layer or coating of hydrophilic polymers such as HPMC or gelatin. Optionally, Eudragit FS 30D or another suitable polymer or agent could be incorporated into the coating composition to retard drug release to ensure release of the drug into the colon.

These coating layers comprise one or more excipients selected from the group comprising coating agents, opacifiers, taste masking agents, fillers, polishing agents, coloring agents, antiadhesive agents and the like.

Coating agents that are useful in the coating process include, but are not limited to, polysaccharides such as maltodextrin, alkyl celluloses such as methyl or ethyl cellulose, hydroxyalkyl celluloses (e.g., hydroxypropylcellulose or hydroxypropylmethylcellulose); polyvinyl pyrrolidone, gum arabic, corn, sucrose, gelatin, shellac, cellulose acetate phthalate, lipids, synthetic resins, acrylic polymers, Opadry, polyvinyl alcohol (PVA), vinyl acetate copolymers and vinylpyrrolidone (for example, marketed under the brand name) Plasdone) and polymers based on methacrylic acid, such as those marketed under the brand name of Eudragit. These can be applied from aqueous or non-aqueous systems or combinations of aqueous and non-aqueous systems, as appropriate. The additives can be included together with the film formers to obtain satisfactory films. These additives may include plasticizers such as dibutyl phthalate, triethyl citrate, polyethylene glycol (PEG) and the like, anti-adherent agents such as talc, stearic acid, magnesium stearate and colloidal silicon dioxide and the like, surface active agents such as polysorbates and lauryl sulfate. sodium, fillers such as talc, precipitated calcium carbonate, polishing agents such as beeswax, carnauba wax, chlorinated synthetic wax and opacifying agents such as titanium dioxide and the like. All of these excipients can be used at levels well known to those skilled in the art.

Pharmaceutical dosage forms comprising a solid dispersion of rifaximin can be coated by various methods. Suitable methods include compression coating, fluidized bed coating or coating (extrusion) layer and hot melt. Such methods are well known to those skilled in the art.

Non-permeable coatings of insoluble polymers, for example, cellulose acetate, ethyl cellulose, can be used as enteric coatings for delayed / modified release (RD / MR) by the inclusion of soluble pore formers in the coating, eg, PEG, PVA, sugars, salts, detergents, triethyl citrate, triacetin, etc.

In addition, polymer coatings that are susceptible to enzymatic cleavage by colon bacteria are other means to ensure their release into the distal ileum and ascending colon. Materials such as calcium pectinate can be applied as coatings to the dosage form and multiple particles and disintegrate in the lower gastrointestinal tract, due to bacterial action. Pectiniform calcium capsules for the encapsulation of multiple bioadhesive particles are also available.

In one embodiment, the coating further comprises the drug.

In one embodiment, the pharmaceutical composition comprising a solid dispersion of rifaximin is multilayer tablets comprising a first and a second and / or a third layer, wherein each layer comprises one or more excipient (s). Multilayer or gradient tablets can be assembled in several different ways.

In one embodiment, the tablet comprising a solid dispersion of rifaximin comprises at least one solid core and two outer layers, comprising one or more pharmaceutical excipients. The core comprises solid dispersion of rifaximin and control release agents. The two outer layers are bioadhesive.

In another embodiment, the tablet comprising a solid dispersion of rifaximin comprises at least one core and two outer layers, comprising the drugs and one or more pharmaceutical excipients. Such tablets can also be used to initiate the release of different drugs at different times, by including different drugs in separate layers.

In another embodiment, the multilayer tablet comprising a solid dispersion of rifaximin is composed of a core and two outer layers, comprising a solid dispersion of rifaximin and one or more pharmaceutical excipients, wherein at least one excipient is hydrophobic .

Another embodiment refers to the composition comprising a solid dispersion of rifaximin, comprising a multilayer tablet in which at least one layer composed of one or more release control agents and the solid dispersion of rifaximin and at least one layer which consists of bioadhesive agents, wherein each layer comprises one or more excipients.

Another embodiment relates to the composition comprising a solid dispersion of rifaximin, comprising a multilayer tablet in which at least one layer is composed of one or more control release agents and at least one layer that is composed of bioadhesive agent, where each layer comprises one or more excipients and the solid dispersion of rifaximin.

The release control agents can be hydrophilic or hydrophobic or combination thereof.

The hydroviral rate control agents are selected from, but not limited to, hydroxyethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose (eg, hypromellose), sodium carboxymethylcellulose, sodium alginate, carbomer (Carbopol ™), xanthan gum, guar gum, carob gum, polyvinyl acetate, polyvinyl alcohol or combinations thereof.

The hydrophobic rate controlling agents in the matrix includes but is not limited to hydrogenated vegetable oil, but other suitable agents include purified grades of beeswax, fatty acids, long chain fatty alcohols, such as cetyl alcohol, myristyl alcohol and alcohol stearyl; glycerides such as glyceryl esters of fatty acids such as glyceryl monostearate, glyceryl distearate, glyceryl esters of hydrogenated castor oil and the like; oils such as mineral oil and the like, or acetylated glycerides; ethyl cellulose, stearic acid, paraffin, carnauba wax, talcum, and salts such as calcium stearate, magnesium, zinc and other materials known to one of ordinary skill in the art or combinations thereof.

Another embodiment refers to the pharmaceutical composition comprising a solid dispersion of rifaximin and at least one swellable polymer. The swellable polymers include, but are not limited to, a crosslinked poly (acrylic acid), a poly (alkylene oxide), a polyvinyl alcohol), a polyvinylpyrrolidone); a polyurethane hydrogel, a maleic anhydride polymer, such as a maleic anhydride copolymer, a cellulose polymer, a polysaccharide, starch and starch based polymers.

The pharmaceutical composition comprising a solid dispersion of rifaximin can be prepared by various methods known in the art, such as by dry granulation, wet granulation, melt granulation, direct compression, double compression, extrusion spheronization, layers and the like.

The pharmaceutical composition comprising a solid dispersion of the rifaximin of the invention will be described in more detail below with reference to examples given below, but only for purposes of illustration and the invention is not limited thereto. 9 Rifaximin 200 rog tablet Ingredients mg / tablet Rifaximin 800 solid dispersion Cellulose microcrystalline 117 Starch glycolate of sodium 38 Silicon dioxide colloidal 20 Mg-eaterate 25 Average weight of 1000 tablet The solid dispersion of rifaximin, microcrystalline cellulose, average amount of each of sodium starch glycollate, colloidal silicon di-oxide and mg-stearate are screened, mixed uniformly and subsequently beaten using roller compactor. They are left to hit and mix with the remaining amount of sodium starch glycolate, colloidal silicon di-oxide and mg stearate and then compressed by suitable punch.

Example 10 able to MR of rlfa imi a of 150 mg Ingredients mg / tatole a Ri-aximine of 600 • solid dispersion Hypromellose 100 iManirol 40 Di-oxide of silicon 20 colloidal Mg-e s earate 25 Average weight of 785 Rabbi The solid dispersion of rifaximin, mannitol, hypromellose, and average amount of each colloidal silicon di-oxide and mg stearate-are screened, mixed uniformly, and then beaten using a roller compactor. They are left to bang and mix with the remaining amount of colloidal silicon di-oxide and mg stearate and then compressed by suitable punch.

Example 11 Rifaximin ER tablet 200 ntg Ingredients mg / tablet First layer Rifaximin dispersion solid 800 Hypromellose 100 Mannitol 40 Microcrystalline cellulose 30 Silicon dioxide colloidal 20 Mg-stearate 25 Average weight of first layer 1015 Second layer (Layer bioadhesi o) Polyethylene oxide 90 Hypromellose 90 Silicon dioxide colloidal 20 Mg-stearate 20 Average weight of second layer 220 Total weight of double-layer tablet 1235 The solid dispersion of rifaximin, mannitol, hypromellose, microcrystalline cellulose and average amount of colloidal silicon di-oxide and mg stearate-are screened, mixed uniformly and subsequently beaten using roller compactor. They are left to bang and and are mixed with the remaining amount of colloidal silicon di-oxide and mg stearate and then compressed by suitable punch. The polyethylene oxide and hypromellose, colloidal silicon dioxide and second layer mg stearate are screened, uniformly mixed and compressed with the drug layer by suitable punch.

Another modality refers to the effect of the solubility of rifaximin in various enteric pathogens or bacterial susceptibility and subsequent eradication.

Another object of the invention is to provide a cost-effective composition of rifaximin or a pharmaceutically acceptable salt.

Another modality refers to the effect of the solubility of rifaximin on various pathogens or bacterial susceptibility and subsequent eradication due to the invasive nature of some enteric pathogens.

Another embodiment refers to the effect of the solubility of rifaximin on the development of resistance to various pathogens or bacterial susceptibility.

However, another form of embodiment refers to the pharmaceutical composition comprising stable solid dispersion comprising rifaximin for the treatment of traveler's diarrhea, hepatic encephalopathy, infectious diarrhea, diverticular disease, an antibacterial prophylactic before colon surgery, irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diarrhea associated with Clostridum difficile, bacterial overgrowth of the small intestine, prophylaxis of traveler's diarrhea, dysentery, pouchitis, peptic ulcer disease, surgical prophylaxis and gastric dyspepsia . In addition, it can be used in the Klebsiella treatment that causes traveler's diarrhea. It can be administered at different dosage regimens, such as several times or once at a dose, at a frequency, and for a duration sufficient to provide a beneficial effect for the patient.

In another embodiment, a rifaximin composition comprising solid dispersion of rifaximin can be administered in combination with a second pharmaceutically active agent, such as antibiotics, antispasmodic agents, anti-inflammatory, anti-infective, diuretic, anti-diabetic, anti-fungal agents. analgesics, antiallergic, anti-ulcerative, antiemetic, immunosuppressant, antiviral, antiretroviral, acid-reducing agents, spheroids, enzymes, enzyme inhibitors, proteins, peptides and antitussives or combinations thereof. The second pharmaceutically active agent can be included in the oral composition and therefore administered in combination with a rifaximin, or can be administered separately. If administered separately, they can be administered substantially at the same time, before, or after administration of the oral composition. The second pharmaceutically active agent can be administered orally or parenterally, for example intravenously. The second pharmaceutically active agent can be provided in the dosages, frequencies of administration, and over the duration of time in combination with rifaximin dose, administration frequencies, and more than effective time duration to provide a beneficial effect for the patient.

In another embodiment, a composition comprising a solid dispersion of rifaximin can be provided as a whole, that is, sealed in a package with instructional materials.

Claims

1. A solid dispersion of rifaximin comprising rifaximin and pharmaceutically acceptable carrier.

2. A solid dispersion according to claim 1, characterized in that the pharmaceutically acceptable carrier is selected from urea, sugar, organic acids, polyethylene glycol, povidone, copovidone, polymethacrylates, polyvinylacetate, cellulose derivatives, own emulsifying carriers, poloxamer, glycerol behanate, polyethylene glycol derivative of a mono-glyceride, vitamin E, polyethylene or polyoxyethylene ester of hydroxyl stearic acid, polyoxylglyceride, polyethoxylated castor oil or combination thereof.

3. A solid dispersion according to claim 1 increases the solubility of rifaximin relative to an equivalent amount of rifaximin.

4. A solid dispersion according to claim 3, characterized in that the solubility of rifaximin is increased by more than 30%.

5. A solid dispersion according to claim 1 increases the gastrointestinal capacity of rifaximin relative to an equivalent amount of rifaximin.

6. A solid dispersion of rifaximin wherein the solubility of rifaximin in the solid dispersion is increased relative to an equivalent amount of rifaximin, while maintaining the equivalent permeability relative to an equivalent amount of rifaximin.

7. A pharmaceutical composition comprising the solid dispersion according to claim 1.

8. A method for treating and / or preventing a microbial infection, comprising administering to a patient in need thereof a therapeutically effective amount of rifaximin solid dispersion according to claim 1.