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MX2012004084A - Anticuerpos siglec-15 para tratar enfermedad relacionada con perdida osea. - Google Patents

Anticuerpos siglec-15 para tratar enfermedad relacionada con perdida osea.

Info

Publication number
MX2012004084A
MX2012004084A MX2012004084A MX2012004084A MX2012004084A MX 2012004084 A MX2012004084 A MX 2012004084A MX 2012004084 A MX2012004084 A MX 2012004084A MX 2012004084 A MX2012004084 A MX 2012004084A MX 2012004084 A MX2012004084 A MX 2012004084A
Authority
MX
Mexico
Prior art keywords
antibodies
siglec
bone
bone loss
binding fragments
Prior art date
Application number
MX2012004084A
Other languages
English (en)
Inventor
Gilles Bernard Tremblay
Mario Filion
Matthew Stuible
Original Assignee
Alethia Biotherapeutics Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43856338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012004084(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alethia Biotherapeutics Inc filed Critical Alethia Biotherapeutics Inc
Publication of MX2012004084A publication Critical patent/MX2012004084A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G01N33/57557—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • G01N2800/108—Osteoporosis

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  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Biotechnology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
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Abstract

La presente describe anticuerpos novedosos y fragmentos de unión a antígeno que específicamente se unen a Siglec-15. En algunas modalidades, los anticuerpos o fragmentos de unión a antígeno pueden bloquear la actividad biológica de Siglec-15 y son útiles en composiciones para el tratamiento de pérdida ósea, más particularmente en enfermedades óseas que tienen expresión incrementada de Siglec-15 en la superficie celular, tales como condiciones en donde hay un incremento en la actividad degenerativa ósea de osteoclastos. La invención también se refiere a células que expresan los anticuerpos o fragmentos de unión a antígeno tales como anticuerpos monoclonales, humanizados o quiméricos. Además también se describen métodos para detectar y tratar pérdida ósea, enfermedades relacionadas con los huesos o cáncer utilizando los anticuerpos y fragmentos.
MX2012004084A 2009-10-06 2010-10-06 Anticuerpos siglec-15 para tratar enfermedad relacionada con perdida osea. MX2012004084A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24896009P 2009-10-06 2009-10-06
US12/580,943 US8168181B2 (en) 2006-02-13 2009-10-16 Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
PCT/CA2010/001586 WO2011041894A1 (en) 2009-10-06 2010-10-06 Siglec 15 antibodies in treating bone loss-related disease

Publications (1)

Publication Number Publication Date
MX2012004084A true MX2012004084A (es) 2012-07-10

Family

ID=43856338

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004084A MX2012004084A (es) 2009-10-06 2010-10-06 Anticuerpos siglec-15 para tratar enfermedad relacionada con perdida osea.

Country Status (13)

Country Link
US (6) US8168181B2 (es)
EP (1) EP2486060A4 (es)
JP (2) JP5855569B2 (es)
KR (1) KR20120086297A (es)
CN (2) CN106046160A (es)
AU (2) AU2010305281C1 (es)
BR (1) BR112012007860A2 (es)
CA (2) CA2775793C (es)
IL (1) IL218985A0 (es)
MX (1) MX2012004084A (es)
NZ (1) NZ599193A (es)
RU (1) RU2596392C2 (es)
WO (1) WO2011041894A1 (es)

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US8168181B2 (en) * 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
CA2822302A1 (en) † 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Methods of impairing osteoclast differentiation
ES2531324T3 (es) * 2007-09-28 2015-03-13 Daiichi Sankyo Co Ltd Intermedio para producir un derivado de gamma-aminoácido bicíclico
RU2475499C2 (ru) 2007-10-11 2013-02-20 Дайити Санкио Компани, Лимитед Антитело, направленное на белок siglec-15, связанный с остеокластами
WO2010110361A1 (ja) 2009-03-26 2010-09-30 第一三共株式会社 二環性γ－アミノ酸誘導体の製造方法
NZ605450A (en) 2009-04-09 2014-07-25 Daiichi Sankyo Co Ltd Anti-siglec-15 antibody
US9114131B2 (en) 2010-10-05 2015-08-25 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein Siglec-15
JP6216317B2 (ja) * 2011-09-09 2017-10-18 メディミューン リミテッド 抗Ｓｉｇｌｅｃ−１５抗体およびその使用
US9003797B2 (en) * 2011-11-02 2015-04-14 E L Du Pont De Nemours And Company Use of compositions comprising 1,1,1,2,3-pentafluoropropane and optionally Z-1,1,1,4,4,4-hexafluoro-2-butene in power cycles
RU2014143798A (ru) 2012-03-30 2016-05-27 Дайити Санкио Компани, Лимитед Антитело к сиглек-15 с модифицированной cdr
US20150125470A1 (en) 2012-03-30 2015-05-07 Daiichi Sankyo Company, Limited Novel anti-siglec-15 antibody
CN104507969A (zh) 2012-07-19 2015-04-08 阿莱斯亚生物疗法股份有限公司 抗siglec-15抗体
RU2656153C1 (ru) * 2013-12-20 2018-05-31 Девелопмент Сентер Фор Байотекнолоджи Антитела, специфичные к альфа-энолазе, и способы применения в противоопухолевой терапии
US9382331B2 (en) * 2013-12-27 2016-07-05 Development Center For Biotechnology Alpha-enolase specific antibodies and methods of uses in cancer therapy
US20170129956A1 (en) * 2014-06-18 2017-05-11 Daiichi Sankyo Company, Limited Anti-siglec-15 antibodies for use in treatment of osteogenesis imperfecta
FR3024731B1 (fr) * 2014-08-08 2019-06-14 International - Drug - Development - Biotech Anticorps anti-ck8 pour utilisation dans le traitement des cancers
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
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CN107427563B (zh) * 2014-12-31 2021-03-02 财团法人生物技术开发中心 人源化α-烯醇酶特异性抗体及用于癌症治疗的方法
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP4512827A3 (en) * 2015-11-10 2025-04-30 Yale University Compositions and methods for treating autoimmune diseases and cancers
CN105367658B (zh) * 2015-12-02 2020-06-16 朱进 人源抗唾液酸结合免疫球蛋白样凝集素-9的抗体IgG及其应用
KR20240035625A (ko) 2016-09-21 2024-03-15 넥스트큐어 인코포레이티드 Siglec-15를 위한 항체 및 이의 사용 방법
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