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MX2012003598A - Anticuerpos biespecificos agonistas de receptores de muerte. - Google Patents

Anticuerpos biespecificos agonistas de receptores de muerte.

Info

Publication number
MX2012003598A
MX2012003598A MX2012003598A MX2012003598A MX2012003598A MX 2012003598 A MX2012003598 A MX 2012003598A MX 2012003598 A MX2012003598 A MX 2012003598A MX 2012003598 A MX2012003598 A MX 2012003598A MX 2012003598 A MX2012003598 A MX 2012003598A
Authority
MX
Mexico
Prior art keywords
death receptor
agonistic antibodies
receptor agonistic
bispecific death
bispecific
Prior art date
Application number
MX2012003598A
Other languages
English (en)
Inventor
Pablo Umana
Peter Bruenker
Claudia Ferrara Koller
Ekkehard Moessner
Sandra Grau
Sylvia Herter
Christoph Lampert
Inja Waldhauer
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of MX2012003598A publication Critical patent/MX2012003598A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a anticuerpos biespecíficos que comprenden un primer sitio de unión a antígenos específico para un receptor de muerte y un segundo sitio de unión a antígenos específico para un segundo antígeno, métodos para su producción, composiciones farmacéuticas que contienen los anticuerpos y usos de los mismos.
MX2012003598A 2009-09-29 2010-09-27 Anticuerpos biespecificos agonistas de receptores de muerte. MX2012003598A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09171659 2009-09-29
PCT/EP2010/064209 WO2011039126A1 (en) 2009-09-29 2010-09-27 Bispecific death receptor agonistic antibodies

Publications (1)

Publication Number Publication Date
MX2012003598A true MX2012003598A (es) 2012-04-20

Family

ID=43086853

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003598A MX2012003598A (es) 2009-09-29 2010-09-27 Anticuerpos biespecificos agonistas de receptores de muerte.

Country Status (18)

Country Link
US (1) US9481730B2 (es)
EP (1) EP2483310B1 (es)
JP (1) JP5695059B2 (es)
KR (1) KR101508043B1 (es)
CN (1) CN102574921B (es)
AU (1) AU2010303142B2 (es)
BR (1) BR112012006326A2 (es)
CA (1) CA2773515C (es)
CY (1) CY1115639T1 (es)
DK (1) DK2483310T3 (es)
ES (1) ES2505269T3 (es)
HR (1) HRP20141032T1 (es)
IL (1) IL218437A (es)
MX (1) MX2012003598A (es)
PL (1) PL2483310T3 (es)
PT (1) PT2483310E (es)
SI (1) SI2483310T1 (es)
WO (1) WO2011039126A1 (es)

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AR085404A1 (es) 2011-02-28 2013-09-25 Hoffmann La Roche Proteinas de union a antigeno
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Also Published As

Publication number Publication date
BR112012006326A2 (pt) 2016-11-16
CN102574921B (zh) 2016-05-04
US9481730B2 (en) 2016-11-01
PL2483310T3 (pl) 2015-01-30
CA2773515A1 (en) 2011-04-07
HK1169132A1 (zh) 2013-01-18
DK2483310T3 (da) 2014-09-01
JP5695059B2 (ja) 2015-04-01
HRP20141032T1 (hr) 2015-01-30
ES2505269T3 (es) 2014-10-09
CN102574921A (zh) 2012-07-11
WO2011039126A1 (en) 2011-04-07
AU2010303142B2 (en) 2013-05-09
EP2483310B1 (en) 2014-08-13
JP2013505732A (ja) 2013-02-21
IL218437A0 (en) 2012-04-30
AU2010303142A1 (en) 2012-03-15
KR101508043B1 (ko) 2015-04-06
US20120184718A1 (en) 2012-07-19
CY1115639T1 (el) 2017-01-04
KR20120056857A (ko) 2012-06-04
EP2483310A1 (en) 2012-08-08
IL218437A (en) 2017-04-30
SI2483310T1 (sl) 2014-12-31
PT2483310E (pt) 2014-10-07
CA2773515C (en) 2015-04-28

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