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MX2012001469A - Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina. - Google Patents

Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina.

Info

Publication number
MX2012001469A
MX2012001469A MX2012001469A MX2012001469A MX2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A MX 2012001469 A MX2012001469 A MX 2012001469A
Authority
MX
Mexico
Prior art keywords
data
group
formula
optionally substituted
suitable substituents
Prior art date
Application number
MX2012001469A
Other languages
English (en)
Inventor
Juergen Schnaubelt
Guenter Linz
Gerd Kraemer
Sabrina Kusserow
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42712695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012001469(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2012001469A publication Critical patent/MX2012001469A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un método para preparar pirimidinas de la fórmula (III), (ver fórmula (III)) donde X2 es un grupo saliente que se selecciona de entre el grupo consistente de feniloxi opcionalmente sustituido por de 1 a 5 sustituyentes adecuados, heterociclil N-oxi opcionalmente sustituido por de 1 a 5 sustituyentes adecuados, y heteroaril N-oxi opcionalmente sustituido por de 1 a 5 sustituyentes adecuados; R1 y R2 son sustituyentes seleccionados de forma independiente de entre el grupo consistente de hidrógeno, un grupo aromático y un grupo alifático, o, tomados juntos, -N(R1)R2 pueden formar un anillo aromático o alifático de 4 a 11 miembros; este método comprende hacer reaccionar un compuesto de la fórmula (1) (ver fórmula (I)) con una amina d la fórmula (II) [HN(R1)R2] para formar un compuesto de la fórmula (II), donde X1 es un grupo saliente.
MX2012001469A 2009-08-14 2010-08-13 Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina. MX2012001469A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167934 2009-08-14
PCT/EP2010/061840 WO2011018518A1 (en) 2009-08-14 2010-08-13 Regioselective preparation of 2 -amino-5-trifluoromethylpyrimidine derivatives

Publications (1)

Publication Number Publication Date
MX2012001469A true MX2012001469A (es) 2012-02-22

Family

ID=42712695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001469A MX2012001469A (es) 2009-08-14 2010-08-13 Reparacion regioselectiva de derivados de 2-amino-5-trifluorometil pirimidina.

Country Status (17)

Country Link
US (1) US8933227B2 (es)
EP (1) EP2464634B1 (es)
JP (1) JP5539519B2 (es)
KR (1) KR20120046248A (es)
CN (1) CN102471287A (es)
AR (1) AR077925A1 (es)
AU (1) AU2010283713A1 (es)
BR (1) BR112012002971A2 (es)
CA (1) CA2767965A1 (es)
CL (1) CL2012000278A1 (es)
EA (1) EA201200282A1 (es)
IL (1) IL217112A0 (es)
IN (1) IN2012DN01342A (es)
MX (1) MX2012001469A (es)
NZ (1) NZ597538A (es)
TW (1) TW201124385A (es)
WO (1) WO2011018518A1 (es)

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UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
US8729265B2 (en) 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
CN102887860B (zh) * 2012-09-29 2015-07-01 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法
JP6391985B2 (ja) * 2014-05-16 2018-09-19 東ソー・ファインケム株式会社 ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6391988B2 (ja) * 2014-05-21 2018-09-19 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体
JP6262079B2 (ja) * 2014-06-02 2018-01-17 東ソー・ファインケム株式会社 ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
JP6431294B2 (ja) * 2014-06-16 2018-11-28 東ソー・ファインケム株式会社 ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法
JP6479486B2 (ja) * 2015-01-16 2019-03-06 東ソー・ファインケム株式会社 ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法

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Also Published As

Publication number Publication date
EP2464634B1 (en) 2016-11-30
AU2010283713A1 (en) 2012-02-02
IN2012DN01342A (es) 2015-06-05
CA2767965A1 (en) 2011-02-17
AR077925A1 (es) 2011-10-05
IL217112A0 (en) 2012-02-29
US20110190499A1 (en) 2011-08-04
KR20120046248A (ko) 2012-05-09
JP2013501759A (ja) 2013-01-17
EP2464634A1 (en) 2012-06-20
CL2012000278A1 (es) 2012-10-12
CN102471287A (zh) 2012-05-23
NZ597538A (en) 2014-05-30
US8933227B2 (en) 2015-01-13
JP5539519B2 (ja) 2014-07-02
EA201200282A1 (ru) 2012-09-28
WO2011018518A1 (en) 2011-02-17
TW201124385A (en) 2011-07-16
BR112012002971A2 (pt) 2015-10-13

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