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MX2012000169A - Compuestos y metodos inhibidores de jak de pirazolopirimidina. - Google Patents

Compuestos y metodos inhibidores de jak de pirazolopirimidina.

Info

Publication number
MX2012000169A
MX2012000169A MX2012000169A MX2012000169A MX2012000169A MX 2012000169 A MX2012000169 A MX 2012000169A MX 2012000169 A MX2012000169 A MX 2012000169A MX 2012000169 A MX2012000169 A MX 2012000169A MX 2012000169 A MX2012000169 A MX 2012000169A
Authority
MX
Mexico
Prior art keywords
sup
air
pharmaceutically acceptable
compound
formula
Prior art date
Application number
MX2012000169A
Other languages
English (en)
Inventor
Paul Gibbons
Emily Hanan
Liu Wendy
Joseph P Lyssikatos
Steven R Magnuson
Rohan Mendonca
Richard Pastor
Thomas E Rawson
Siu Michael
Aihe Zhou
Mark E Zak
Bing-Yan Zhu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2012000169A publication Critical patent/MX2012000169A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuesto de la Fórmula I, enantiómeros, diasteriómeros, tautómeros o sales farmacéuticamente aceptables de los mismos, en donde R1, R2 y R3 se definen aquí como inhibidores de una o más quinasas Janus. Se divulgan una composición farmacéutica que incluye un compuesto de la Fórmula I y un portador, auxiliar o vehículo farmacéuticamente aceptable, y métodos para tratar o disminuir la severidad de una enfermedad o condición que responde a la inhibición de una actividad de la quinasa Jañus en un paciente.
MX2012000169A 2009-07-02 2010-07-02 Compuestos y metodos inhibidores de jak de pirazolopirimidina. MX2012000169A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22291809P 2009-07-02 2009-07-02
PCT/US2010/040906 WO2011003065A2 (en) 2009-07-02 2010-07-02 Pyrazolopyrimidine jak inhibitor compounds and methods

Publications (1)

Publication Number Publication Date
MX2012000169A true MX2012000169A (es) 2012-03-29

Family

ID=43411778

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000169A MX2012000169A (es) 2009-07-02 2010-07-02 Compuestos y metodos inhibidores de jak de pirazolopirimidina.

Country Status (35)

Country Link
US (6) US8999998B2 (es)
EP (3) EP2448941B1 (es)
JP (4) JP5769261B2 (es)
KR (3) KR20180108858A (es)
CN (2) CN102482284B (es)
AU (1) AU2010266188B2 (es)
BR (1) BRPI1010197A2 (es)
CA (1) CA2767097A1 (es)
CL (1) CL2012000001A1 (es)
CO (1) CO6491081A2 (es)
CR (2) CR20170115A (es)
DK (1) DK2448941T3 (es)
EC (1) ECSP12011645A (es)
ES (1) ES2657839T3 (es)
HR (1) HRP20180157T1 (es)
HU (1) HUE035537T2 (es)
IL (3) IL217224B (es)
IN (1) IN2012DN00755A (es)
LT (1) LT2448941T (es)
MA (1) MA33502B1 (es)
MX (1) MX2012000169A (es)
MY (1) MY160156A (es)
NO (1) NO2448941T3 (es)
NZ (4) NZ738778A (es)
PE (2) PE20151249A1 (es)
PH (1) PH12015500666A1 (es)
PL (1) PL2448941T3 (es)
PT (1) PT2448941T (es)
RS (1) RS56671B1 (es)
RU (2) RU2675857C2 (es)
SG (2) SG177454A1 (es)
SI (1) SI2448941T1 (es)
UA (1) UA110324C2 (es)
WO (1) WO2011003065A2 (es)
ZA (2) ZA201200490B (es)

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