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MX2019007339A - Compuestos de pirazolopirimidina y metodos de uso de los mismos. - Google Patents

Compuestos de pirazolopirimidina y metodos de uso de los mismos.

Info

Publication number
MX2019007339A
MX2019007339A MX2019007339A MX2019007339A MX2019007339A MX 2019007339 A MX2019007339 A MX 2019007339A MX 2019007339 A MX2019007339 A MX 2019007339A MX 2019007339 A MX2019007339 A MX 2019007339A MX 2019007339 A MX2019007339 A MX 2019007339A
Authority
MX
Mexico
Prior art keywords
methods
pyrazolopyrimidine compounds
compounds
pyrazolopyrimidine
formula
Prior art date
Application number
MX2019007339A
Other languages
English (en)
Inventor
Yuen Po-Wai
Li Wei
Zhao Guiling
Zak Mark
Gibbons Paul
Anthony Romero F
Cheng Yun-Xing
Cheng Limin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2019007339A publication Critical patent/MX2019007339A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (IA) o una sal de los mismos farmacéuticamente aceptable y métodos de uso como inhibidores de Janus cinasa.
MX2019007339A 2016-12-29 2017-12-22 Compuestos de pirazolopirimidina y metodos de uso de los mismos. MX2019007339A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016112932 2016-12-29
PCT/EP2017/084569 WO2018122212A1 (en) 2016-12-29 2017-12-22 Pyrazolopyrimidine compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2019007339A true MX2019007339A (es) 2019-09-06

Family

ID=61094385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007339A MX2019007339A (es) 2016-12-29 2017-12-22 Compuestos de pirazolopirimidina y metodos de uso de los mismos.

Country Status (19)

Country Link
US (1) US11155557B2 (es)
EP (1) EP3562809B1 (es)
JP (1) JP6900491B2 (es)
KR (1) KR20190100337A (es)
CN (1) CN110114343B (es)
AU (1) AU2017385543A1 (es)
BR (1) BR112019013287A2 (es)
CA (1) CA3046435A1 (es)
CL (1) CL2019001694A1 (es)
CO (1) CO2019006220A2 (es)
CR (1) CR20190310A (es)
IL (1) IL267671A (es)
MA (1) MA47167A (es)
MX (1) MX2019007339A (es)
PE (1) PE20191236A1 (es)
PH (1) PH12019501022A1 (es)
RU (1) RU2019123319A (es)
UA (1) UA122851C2 (es)
WO (1) WO2018122212A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019007339A (es) 2016-12-29 2019-09-06 Hoffmann La Roche Compuestos de pirazolopirimidina y metodos de uso de los mismos.
SG11201909735YA (en) 2017-05-22 2019-11-28 Hoffmann La Roche Therapeutic compounds and compositions, and methods of use thereof
WO2019139714A1 (en) * 2018-01-15 2019-07-18 Genentech, Inc. Pyrazolopyrimidine compounds as jak inhibitors
CN114008051B (zh) 2019-06-18 2024-08-13 豪夫迈·罗氏有限公司 Jak激酶的吡唑并嘧啶砜抑制剂及其用途
WO2020257142A1 (en) * 2019-06-18 2020-12-24 Genentech, Inc. Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof
WO2020257143A1 (en) 2019-06-18 2020-12-24 Genentech, Inc. Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
WO2022175829A1 (en) * 2021-02-17 2022-08-25 Cellix Bio Private Limited Topical formulations and compositions
AU2023336560A1 (en) * 2022-09-09 2025-04-17 Chiesi Farmaceutici S.P.A. Heterocyclic derivatives as janus kinase inhibitors
KR20250060914A (ko) * 2022-09-09 2025-05-07 키에시 파르마슈티시 엣스. 피. 에이. 야누스 키나아제 억제제로서 헤테로사이클릭 유도체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
WO2003053930A1 (en) 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
CN102127078A (zh) 2005-07-14 2011-07-20 安斯泰来制药株式会社 Janus激酶3的杂环类抑制剂
CA2727036C (en) 2008-06-20 2017-03-21 Genentech, Inc. Triazolopyridine jak inhibitor compounds and methods
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
PE20211782A1 (es) 2014-05-23 2021-09-08 Hoffmann La Roche Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
CN108473501B (zh) 2016-02-18 2021-07-16 豪夫迈·罗氏有限公司 治疗化合物、其组合物及使用方法
CA3029518A1 (en) 2016-06-29 2018-01-04 Hanmi Pharm. Co., Ltd. Glucagon derivative, conjugate thereof, composition comprising same, and therapeutic use thereof
MX2019007339A (es) 2016-12-29 2019-09-06 Hoffmann La Roche Compuestos de pirazolopirimidina y metodos de uso de los mismos.

Also Published As

Publication number Publication date
CO2019006220A2 (es) 2019-06-28
IL267671A (en) 2019-08-29
CN110114343A (zh) 2019-08-09
AU2017385543A1 (en) 2019-05-23
CR20190310A (es) 2019-08-21
CN110114343B (zh) 2022-09-06
MA47167A (fr) 2019-11-06
UA122851C2 (uk) 2021-01-06
KR20190100337A (ko) 2019-08-28
CA3046435A1 (en) 2018-07-05
PH12019501022A1 (en) 2019-12-16
US11155557B2 (en) 2021-10-26
EP3562809A1 (en) 2019-11-06
EP3562809B1 (en) 2021-06-09
CL2019001694A1 (es) 2019-11-22
RU2019123319A (ru) 2021-02-01
PE20191236A1 (es) 2019-09-11
JP2020503339A (ja) 2020-01-30
BR112019013287A2 (pt) 2019-12-24
WO2018122212A1 (en) 2018-07-05
RU2019123319A3 (es) 2021-02-01
JP6900491B2 (ja) 2021-07-07
US20190345165A1 (en) 2019-11-14

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