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MX2011012629A - Inhibidores de actividad de cinasa tipo pirimidina. - Google Patents

Inhibidores de actividad de cinasa tipo pirimidina.

Info

Publication number
MX2011012629A
MX2011012629A MX2011012629A MX2011012629A MX2011012629A MX 2011012629 A MX2011012629 A MX 2011012629A MX 2011012629 A MX2011012629 A MX 2011012629A MX 2011012629 A MX2011012629 A MX 2011012629A MX 2011012629 A MX2011012629 A MX 2011012629A
Authority
MX
Mexico
Prior art keywords
sup
kinase activity
compounds
pyrimidine inhibitors
pyrimidine
Prior art date
Application number
MX2011012629A
Other languages
English (en)
Inventor
Scott A Erickson
George S Sheppard
Jieyi Wang
Steve D Fidanze
Gary T Wang
Bryan K Sorensen
Richard F Clark
Randy L Bell
Robert A Mantei
Nwe Y Ba-Maung
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011012629A publication Critical patent/MX2011012629A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En la presente solicitud se describen compuestos de la fórmula (I) o sales o solvatos farmacéuticamente aceptables de los mismos, en la cual G1, L1, R2, R3, n, p, Ar1, y Ar2 se definen en la descripción. También se describen métodos para elaborar dichos compuestos, y composiciones que comprenden dichos compuestos los cuales son útiles para inhibir cinasas tales como IGF-IR.
MX2011012629A 2009-05-27 2010-05-26 Inhibidores de actividad de cinasa tipo pirimidina. MX2011012629A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18155509P 2009-05-27 2009-05-27
PCT/US2010/036184 WO2010138575A1 (en) 2009-05-27 2010-05-26 Pyrimidine inhibitors of kinase activity

Publications (1)

Publication Number Publication Date
MX2011012629A true MX2011012629A (es) 2012-03-06

Family

ID=42352237

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012629A MX2011012629A (es) 2009-05-27 2010-05-26 Inhibidores de actividad de cinasa tipo pirimidina.

Country Status (8)

Country Link
US (1) US8536180B2 (es)
EP (1) EP2435435B1 (es)
JP (1) JP2012528174A (es)
CN (1) CN102459265A (es)
CA (1) CA2763624A1 (es)
ES (1) ES2453097T3 (es)
MX (1) MX2011012629A (es)
WO (1) WO2010138575A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
GB2480815A (en) * 2010-06-01 2011-12-07 Summit Corp Plc Compounds for the treatment of clostridium difficile-associated disease
PT2575968E (pt) 2010-06-01 2016-06-20 Summit Therapeutics Plc Compostos para o tratamento de doença associada com clostridium difficile
CN104918919A (zh) 2012-11-21 2015-09-16 Ptc医疗公司 取代的反向嘧啶Bmi-1抑制剂
NZ748260A (en) 2013-08-30 2020-01-31 Ptc Therapeutics Inc Substituted pyrimidine bmi-1 inhibitors
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
EP3836932A2 (en) 2018-08-17 2021-06-23 PTC Therapeutics, Inc. Method for treating pancreatic cancer
CN114502555B (zh) * 2019-10-15 2024-07-16 常州千红生化制药股份有限公司 用于治疗增殖性疾病和疾患的4-(咪唑并[1,2-a]吡啶-3-基)-N-(吡啶-3-基)嘧啶-2-胺的衍生物
CN110627775B (zh) * 2019-10-24 2026-01-30 特科罗生物科技(成都)有限公司 一种小分子化合物
UY38979A (es) 2019-12-06 2021-07-30 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
TW202313593A (zh) 2021-06-04 2023-04-01 美商維泰克斯製藥公司 作為鈉通道調節劑之ｎ—（羥基烷基（雜）芳基）四氫呋喃甲醯胺
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004174A9 (en) * 2000-02-17 2003-01-02 Armistead David M. Kinase inhibitors
BR0208373A (pt) * 2001-03-28 2005-02-22 Bristol Myers Squibb Co Inibidores da tirosina cinase
US7074801B1 (en) * 2001-04-26 2006-07-11 Eisai Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
UA80296C2 (en) * 2002-09-06 2007-09-10 Biogen Inc Imidazolopyridines and methods of making and using the same
WO2004035588A1 (en) * 2002-10-15 2004-04-29 Smithkline Beecham Corporation Pyradazine compounds as gsk-3 inhibitors
EP1706400A1 (en) * 2004-01-09 2006-10-04 Novartis AG Phenyl- 4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl -amine derivatives as igf-ir inhibitors
WO2006068826A2 (en) * 2004-12-21 2006-06-29 Smithkline Beecham Corporation 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors
US8211929B2 (en) * 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
EP1917258A2 (en) * 2005-08-26 2008-05-07 SmithKline Beecham Corporation Pyrimidinyl-pyrazole inhibitors of aurora kinases
US20090306116A1 (en) * 2005-09-16 2009-12-10 Astrazeneca Ab Pyrimidine derivatives for the inhibition of igf-ir tyrosine kinase activity
CA2669736C (en) * 2005-11-03 2017-02-21 Chembridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
US7807673B2 (en) * 2005-12-05 2010-10-05 Glaxosmithkline Llc 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors
UY30183A1 (es) 2006-03-02 2007-10-31 Astrazeneca Ab Derivados de quinolina
WO2008150799A1 (en) * 2007-06-01 2008-12-11 Smithkline Beecham Corporation Imidazopyridine kinase inhibitors
US8067409B2 (en) * 2007-11-27 2011-11-29 Abbott Laboratories Protein kinase inhibitors
CN102459264A (zh) * 2009-05-27 2012-05-16 雅培制药有限公司 激酶活性的嘧啶抑制剂

Also Published As

Publication number Publication date
CA2763624A1 (en) 2010-12-02
WO2010138575A1 (en) 2010-12-02
JP2012528174A (ja) 2012-11-12
US8536180B2 (en) 2013-09-17
EP2435435B1 (en) 2014-01-29
ES2453097T3 (es) 2014-04-04
US20100305118A1 (en) 2010-12-02
CN102459265A (zh) 2012-05-16
EP2435435A1 (en) 2012-04-04

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Owner name: ABBVIE INC.

FG Grant or registration