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MX2010010353A - Proteinas hibridas hipoalergenicas de los alergenos mayoritarios de acaros pertenecientes a los grupos 1 y 2 utiles para su utilizacion en el tratamiento de alergias. - Google Patents

Proteinas hibridas hipoalergenicas de los alergenos mayoritarios de acaros pertenecientes a los grupos 1 y 2 utiles para su utilizacion en el tratamiento de alergias.

Info

Publication number
MX2010010353A
MX2010010353A MX2010010353A MX2010010353A MX2010010353A MX 2010010353 A MX2010010353 A MX 2010010353A MX 2010010353 A MX2010010353 A MX 2010010353A MX 2010010353 A MX2010010353 A MX 2010010353A MX 2010010353 A MX2010010353 A MX 2010010353A
Authority
MX
Mexico
Prior art keywords
treatment
allergies
hybrid proteins
allergens
major group
Prior art date
Application number
MX2010010353A
Other languages
English (en)
Inventor
Ortega Juan Andres Asturias
Garate Alberto Martinez
Lopez De Davalillo Inaki Ibarrola
Rodriguez Maria Carmen Arilla
Original Assignee
Bial Ind Farmaceutica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Ind Farmaceutica S A filed Critical Bial Ind Farmaceutica S A
Publication of MX2010010353A publication Critical patent/MX2010010353A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a moléculas de ADN recombinantes que codifican polipéptidos híbridos de diferentes alergenos del D. pteronyssinus, útiles para la prevención y tratamiento de alergias, particularmente alergias causadas por ácaros. Específicamente, la invención describe proteínas híbridas compuestas de fragmentos de alergenos Derp p 1 y Derp p 2 con características hipoalergénicas, y mantienen su capacidad irmtunogénica, siendo particularmente útil para el tratamiento de alergias. La invención también describe la producción de métodos de estos polipéptidos en sistemas de expresión heteróloga. Además, la invención describe métodos eficientes de purificación de estas proteínas híbridas.
MX2010010353A 2008-03-25 2009-03-24 Proteinas hibridas hipoalergenicas de los alergenos mayoritarios de acaros pertenecientes a los grupos 1 y 2 utiles para su utilizacion en el tratamiento de alergias. MX2010010353A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200800827 2008-03-25
PCT/IB2009/005114 WO2009118642A2 (en) 2008-03-25 2009-03-24 Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies

Publications (1)

Publication Number Publication Date
MX2010010353A true MX2010010353A (es) 2010-10-05

Family

ID=41110539

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010353A MX2010010353A (es) 2008-03-25 2009-03-24 Proteinas hibridas hipoalergenicas de los alergenos mayoritarios de acaros pertenecientes a los grupos 1 y 2 utiles para su utilizacion en el tratamiento de alergias.

Country Status (9)

Country Link
US (2) US8951530B2 (es)
EP (3) EP2268662A2 (es)
JP (2) JP5793073B2 (es)
CN (2) CN101977929B (es)
BR (1) BRPI0908848A2 (es)
CA (1) CA2718994C (es)
ES (2) ES2638308T3 (es)
MX (1) MX2010010353A (es)
WO (1) WO2009118642A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011260233C1 (en) * 2010-06-03 2015-04-16 Alk-Abello A/S Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof
EP2460824A1 (en) * 2010-12-01 2012-06-06 Biomay Ag Hypoallergenic polypeptides for the treatment of house dust mite allergy
CN102676568A (zh) * 2012-05-08 2012-09-19 崔玉宝 一种生产重组粉尘螨变应原Der f1和Der f2融合蛋白的方法
WO2014045084A1 (es) 2012-09-20 2014-03-27 Universidad De Cartagena Proteínas de fusión con representación de diferentes alergenos: propuesta de vacuna para alergia a los ácaros
TWI710569B (zh) * 2014-12-02 2020-11-21 日商大鵬藥品工業股份有限公司 新穎美洲室塵蟎蛋白質
NL2014882B1 (en) 2015-05-29 2017-01-31 Citeq B V Allergy-specific immunotherapy compositions for use in the treatment of house-dust mite allergy.
CA2999930A1 (en) * 2015-09-30 2017-04-06 Boehringer Ingelheim Vetmedica Gmbh Improved modular antigen transportation molecules and uses therof in animals
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
GB201602850D0 (en) * 2016-02-18 2016-04-06 Bial Ind Farmaceutica S A Fusion proteins
CN108265056B (zh) 2016-12-31 2019-08-30 江苏众红生物工程创药研究院有限公司 一种重组户尘螨1类变应原蛋白及其制备方法和应用
CN109852652B (zh) * 2017-11-30 2023-05-02 江苏众红生物工程创药研究院有限公司 重组尘螨Ⅰ型变应原Der p1和Der f1蛋白的制备与应用
EP3569612A1 (en) * 2018-05-18 2019-11-20 Biomay Ag Treatment and prevention of house dust mite allergies
CN113831400A (zh) * 2021-07-29 2021-12-24 沈阳医学院 一种尘螨致敏蛋白Der p 1的分离纯化方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2993967B2 (ja) * 1987-06-17 1999-12-27 インスティテュート・フォー・チャイルド・ヘルス・リサーチ ダニアレルゲンのクローニング
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
US7288256B1 (en) 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
GB9724531D0 (en) 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
EP1221317A1 (en) 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
FR2841906B1 (fr) 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
ES2247433T3 (es) 2003-01-21 2006-03-01 Biomay Produktions- Und Handels- Aktiengesellschaft Procedimiento para la preparacion de proteinas de mosaico hipoalergenicas.
CN1780852A (zh) * 2003-04-25 2006-05-31 诺和酶股份有限公司 组1螨多肽变体
ITRM20040103A1 (it) 2004-02-27 2004-05-27 Consiglio Nazionale Ricerche Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono.
AT501101B1 (de) 2004-12-02 2008-01-15 Biomay Ag Protein-allergen-derivat
US20070065468A1 (en) * 2005-08-29 2007-03-22 National University Of Singapore Chimeric allergens for immunotherapy
CN100374152C (zh) * 2005-12-23 2008-03-12 中国农业大学 一种过敏性反应抑制剂
GB0607377D0 (en) 2006-04-12 2006-05-24 Glaxosmithkline Biolog Sa Novel Methods
EP1908776A1 (en) * 2006-10-06 2008-04-09 Stallergenes Sa Mite fusion proteins
EP1908777B1 (en) 2006-10-06 2016-02-03 Stallergenes Mite fusion proteins

Also Published As

Publication number Publication date
JP2015164424A (ja) 2015-09-17
CN101977929B (zh) 2016-10-19
EP2436692B1 (en) 2017-08-02
US20110052640A1 (en) 2011-03-03
CA2718994A1 (en) 2009-10-01
ES2638271T3 (es) 2017-10-19
BRPI0908848A2 (pt) 2015-12-01
US8951530B2 (en) 2015-02-10
JP6068544B2 (ja) 2017-01-25
CN101977929A (zh) 2011-02-16
JP2011517407A (ja) 2011-06-09
EP2436692A3 (en) 2012-06-27
EP2268662A2 (en) 2011-01-05
EP2436691B1 (en) 2017-08-02
WO2009118642A3 (en) 2009-12-03
CN107118265A (zh) 2017-09-01
US20150152148A1 (en) 2015-06-04
EP2436691A2 (en) 2012-04-04
ES2638308T3 (es) 2017-10-19
JP5793073B2 (ja) 2015-10-14
WO2009118642A2 (en) 2009-10-01
EP2436692A2 (en) 2012-04-04
EP2436691A3 (en) 2012-06-27
CA2718994C (en) 2017-06-13

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