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MX2010009195A - Rnas ultrapequeños como antagonistas del receptor tipo toll-3. - Google Patents

Rnas ultrapequeños como antagonistas del receptor tipo toll-3.

Info

Publication number
MX2010009195A
MX2010009195A MX2010009195A MX2010009195A MX2010009195A MX 2010009195 A MX2010009195 A MX 2010009195A MX 2010009195 A MX2010009195 A MX 2010009195A MX 2010009195 A MX2010009195 A MX 2010009195A MX 2010009195 A MX2010009195 A MX 2010009195A
Authority
MX
Mexico
Prior art keywords
tlr3
nucleotides
target
less
double
Prior art date
Application number
MX2010009195A
Other languages
English (en)
Inventor
Ambati Jayakrishna
Original Assignee
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found filed Critical Univ Kentucky Res Found
Publication of MX2010009195A publication Critical patent/MX2010009195A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects

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  • Health & Medical Sciences (AREA)
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Abstract

Se proporcionan los métodos y composiciones para el tratamiento o prevención de degeneración macular u otras enfermedades o trastornos asociados con la activación de TLR3 (receptor-3 tipo Toll). La administración de los RNA bicatenarios con una longitud de 22 nucleótidos o menos trata o previene la degeneración macular u otras enfermedades o trastornos asociados con la activación del TLR3 debido a la capacidad que tienen los RNA para unirse a, pero no activar, el TLR3. Además, todos los RNA bicatenarios (dirigidos y no dirigidos) de 22 nucleótidos o menos de longitud pueden unirse a, pero no activar, el TLR3 y con ello tratar o prevenir estos estados. También se proporciona un método para aumentar la especificidad de un siRNA deseado elegido para disminuir su expresión (knockdown), el método consiste en administrar una cantidad de un siRNA diana suficiente para disminuir la expresión (knockdown) de un gen diana y una cantidad de un RNA bicatenario de 22 nucleótidos o menos, el cual impide que el siRNA diana active el TLR3.
MX2010009195A 2008-02-21 2009-02-20 Rnas ultrapequeños como antagonistas del receptor tipo toll-3. MX2010009195A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3048708P 2008-02-21 2008-02-21
PCT/US2009/001106 WO2009105260A2 (en) 2008-02-21 2009-02-20 Ultra-small rnas as toll-like receptor-3 antagonists

Publications (1)

Publication Number Publication Date
MX2010009195A true MX2010009195A (es) 2011-03-02

Family

ID=40986111

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009195A MX2010009195A (es) 2008-02-21 2009-02-20 Rnas ultrapequeños como antagonistas del receptor tipo toll-3.

Country Status (7)

Country Link
US (1) US8481508B2 (es)
EP (1) EP2257313A2 (es)
JP (1) JP2011518116A (es)
AU (1) AU2009215795A1 (es)
CA (1) CA2716326A1 (es)
MX (1) MX2010009195A (es)
WO (1) WO2009105260A2 (es)

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WO2014159990A1 (en) * 2013-03-13 2014-10-02 Yale University Interferon production using short rna duplexes
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KR102825945B1 (ko) 2016-02-02 2025-06-30 올릭스 주식회사 Angpt2 및 pdgfb를 표적화하는 rna 복합체를 사용하는 혈관신생 관련 질환의 치료
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JP7049262B2 (ja) 2016-04-11 2022-04-06 オリックス ファーマシューティカルズ，インコーポレーテッド 結合組織成長因子を標的とするｒｎａ複合体を用いた特発性肺胞線維症の治療
CN109415731A (zh) 2016-05-06 2019-03-01 埃克西奎雷股份有限公司 呈递用于特异性敲低白介素17受体mRNA的反义寡核苷酸(ASO)的脂质体球形核酸(SNA)构建体
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
KR20190108167A (ko) 2017-02-10 2019-09-23 성균관대학교산학협력단 Rna 간섭을 위한 긴 이중가닥 rna
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
JP2021529173A (ja) 2018-06-20 2021-10-28 イエール ユニバーシティ Ｒｉｇ−ｉアゴニストおよびそれを使用した処置
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
US11649457B2 (en) 2020-12-09 2023-05-16 Yale University Methods for treating SARS-CoV-2 infection
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Also Published As

Publication number Publication date
EP2257313A2 (en) 2010-12-08
US20110097390A1 (en) 2011-04-28
US8481508B2 (en) 2013-07-09
AU2009215795A1 (en) 2009-08-27
JP2011518116A (ja) 2011-06-23
WO2009105260A2 (en) 2009-08-27
CA2716326A1 (en) 2009-08-27
WO2009105260A3 (en) 2009-12-30

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