MX2010007351A - Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- MX2010007351A MX2010007351A MX2010007351A MX2010007351A MX2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- optionally substituted
- alkyl
- alkoxy
- atom
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- BEHYAANJUKYBTH-UHFFFAOYSA-N imidazo[1,2-a]pyridine-2-carboxamide Chemical class C1=CC=CC2=NC(C(=O)N)=CN21 BEHYAANJUKYBTH-UHFFFAOYSA-N 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxyiminoalkyl Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a compuestos de fórmula (I) en la cual: X e Y definen, junto con el átomo nitrógeno llevado por los mismos, un amino monocíclico o bicíclico saturado o parcialmente saturado con 5 a 10 enlaces que opcionalmente incluyen 1 a 2 heteroátomos adicionales seleccionados de O, S, N y opcionalmente sustituidos por un átomo de halógeno, un grupo alquilo de 1 a 6 átomos de carbono, un grupo alcoxi de 1 a 6 átomos de carbono, ciano, NRaRb, COOR8, los grupos alquilo de 1 a 6 átomos de carbono y alcoxi de 1 a 6 átomos de carbono se sustituyen opcionalmente por uno o más átomos de halógeno; R1 es un átomo de hidrógeno, un átomo de halógeno, un grupo alcoxi de 1 a 6 átomos de carbono, un grupo alquilo de 1 a 6 átomos de carbono; R2 es un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono opcionalmente sustituido, un grupo alcoxi de 1 a 6 átomos de carbono opcionalmente sustituido, un grupo alquenilo de 2 a 6 átomos de carbono, un grupo alquinilo de 2 a 6 átomos de carbono, un grupo -CO-R5, un grupo -CO-NR6R7, un grupo CO-O-R8, un grupo -NR9-CO-R10, un grupo -N=CH-NraRb, un átomo de halógeno, un grupo ciano, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo, un grupo alquiltio de 1 a 6 átomos de carbono, un grupo alquilsulfinilo de 1 a 6 átomos de carbono, un grupo alquilsulfonilo de 1 a 6 átomos de carbono, un grupo ((alquilo de 1 a 6 átomos de carbono)3)sililetinilo, un grupo -SO2-NR9R10, un grupo fenilo opcionalmente sustituido, un grupo heterocíclico opcionalmente sustituido; R3 es un átomo de hidrógeno, un grupo alquilo de 2 a 6 átomos de carbono, un grupo alcoxi de 1 a 6 átomos de carbono o un átomo de halógeno; R4 es un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un grupo alcoxi de 1 a 4 átomos de carbono o un átomo flúor; en donde los compuestos están en la forma de una base o una sal de adición a un ácido. La invención puede utilizarse en terapéutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800004A FR2925902B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| PCT/FR2008/001835 WO2009112651A1 (fr) | 2008-01-02 | 2008-12-31 | Dérivés d'mtoazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010007351A true MX2010007351A (es) | 2010-10-05 |
Family
ID=39739369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010007351A MX2010007351A (es) | 2008-01-02 | 2008-12-31 | Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20100317656A1 (es) |
| EP (1) | EP2225244A1 (es) |
| JP (1) | JP2011508759A (es) |
| KR (1) | KR20100109941A (es) |
| CN (1) | CN101959886A (es) |
| AR (1) | AR070073A1 (es) |
| AU (1) | AU2008352728A1 (es) |
| BR (1) | BRPI0822223A2 (es) |
| CA (1) | CA2710797A1 (es) |
| CL (1) | CL2008003927A1 (es) |
| CO (1) | CO6331307A2 (es) |
| EA (1) | EA201070817A1 (es) |
| FR (1) | FR2925902B1 (es) |
| IL (1) | IL206673A0 (es) |
| MA (1) | MA32057B1 (es) |
| MX (1) | MX2010007351A (es) |
| PA (1) | PA8810101A1 (es) |
| PE (1) | PE20091182A1 (es) |
| TW (1) | TW200932746A (es) |
| UY (1) | UY31588A1 (es) |
| WO (1) | WO2009112651A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| US8809541B2 (en) * | 2010-08-25 | 2014-08-19 | Neopharm Co., Ltd. | Heterocyclic compound, and composition for treating inflammatory diseases using same |
| JP6800158B2 (ja) | 2015-02-20 | 2020-12-16 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｇｄｆ−８阻害剤 |
| PT3684767T (pt) | 2017-09-22 | 2024-07-29 | Jubilant Epipad LLC | Compostos heterocíclicos como inibidores de pad |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| CN107915752B (zh) * | 2017-11-14 | 2018-09-18 | 牡丹江医学院 | 一种治疗白内障的药物及其制备方法 |
| AU2018372211B2 (en) | 2017-11-24 | 2023-02-02 | Jubilant Episcribe LLC, | Heterocyclic compounds as PRMT5 inhibitors |
| JP7279063B6 (ja) | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Ｐｄ１／ｐｄ－ｌ１相互作用／活性化の阻害剤としての二環式化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
| US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
| FR2696177B1 (fr) * | 1992-09-28 | 1995-05-12 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
| GB0420519D0 (en) * | 2004-09-15 | 2004-10-20 | Novartis Ag | Organic compounds |
| CA2695989A1 (en) * | 2007-08-10 | 2009-02-19 | Glaxosmithkline Llc | Certain nitrogen containing bicyclic chemical entities for treating viral infections |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2008
- 2008-01-02 FR FR0800004A patent/FR2925902B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810101A patent/PA8810101A1/es unknown
- 2008-12-30 AR ARP080105778A patent/AR070073A1/es unknown
- 2008-12-30 PE PE2008002195A patent/PE20091182A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003927A patent/CL2008003927A1/es unknown
- 2008-12-30 UY UY31588A patent/UY31588A1/es not_active Application Discontinuation
- 2008-12-31 CA CA2710797A patent/CA2710797A1/fr not_active Abandoned
- 2008-12-31 CN CN2008801277688A patent/CN101959886A/zh active Pending
- 2008-12-31 TW TW097151675A patent/TW200932746A/zh unknown
- 2008-12-31 MX MX2010007351A patent/MX2010007351A/es not_active Application Discontinuation
- 2008-12-31 KR KR1020107017147A patent/KR20100109941A/ko not_active Withdrawn
- 2008-12-31 BR BRPI0822223-1A patent/BRPI0822223A2/pt not_active IP Right Cessation
- 2008-12-31 EP EP08873283A patent/EP2225244A1/fr not_active Ceased
- 2008-12-31 WO PCT/FR2008/001835 patent/WO2009112651A1/fr not_active Ceased
- 2008-12-31 EA EA201070817A patent/EA201070817A1/ru unknown
- 2008-12-31 AU AU2008352728A patent/AU2008352728A1/en not_active Abandoned
- 2008-12-31 JP JP2010541084A patent/JP2011508759A/ja not_active Withdrawn
-
2010
- 2010-06-28 IL IL206673A patent/IL206673A0/en unknown
- 2010-07-01 US US12/828,372 patent/US20100317656A1/en not_active Abandoned
- 2010-07-02 CO CO10080876A patent/CO6331307A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33055A patent/MA32057B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101959886A (zh) | 2011-01-26 |
| AR070073A1 (es) | 2010-03-10 |
| US20100317656A1 (en) | 2010-12-16 |
| WO2009112651A1 (fr) | 2009-09-17 |
| PA8810101A1 (es) | 2009-08-26 |
| FR2925902A1 (fr) | 2009-07-03 |
| KR20100109941A (ko) | 2010-10-11 |
| UY31588A1 (es) | 2009-08-03 |
| CO6331307A2 (es) | 2011-10-20 |
| IL206673A0 (en) | 2010-12-30 |
| EA201070817A1 (ru) | 2011-02-28 |
| EP2225244A1 (fr) | 2010-09-08 |
| PE20091182A1 (es) | 2009-08-31 |
| TW200932746A (en) | 2009-08-01 |
| JP2011508759A (ja) | 2011-03-17 |
| CL2008003927A1 (es) | 2010-02-12 |
| BRPI0822223A2 (pt) | 2015-06-23 |
| AU2008352728A1 (en) | 2009-09-17 |
| MA32057B1 (fr) | 2011-02-01 |
| FR2925902B1 (fr) | 2011-01-07 |
| CA2710797A1 (fr) | 2009-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |