[go: up one dir, main page]

MX2010006211A - Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. - Google Patents

Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas.

Info

Publication number
MX2010006211A
MX2010006211A MX2010006211A MX2010006211A MX2010006211A MX 2010006211 A MX2010006211 A MX 2010006211A MX 2010006211 A MX2010006211 A MX 2010006211A MX 2010006211 A MX2010006211 A MX 2010006211A MX 2010006211 A MX2010006211 A MX 2010006211A
Authority
MX
Mexico
Prior art keywords
elastase proteins
methods
recombinant
manufacturing
proteins
Prior art date
Application number
MX2010006211A
Other languages
English (en)
Inventor
F Nicholas Franano
Kimberly Bland
Marco D Wong
Bee C Ding
Original Assignee
Proteon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteon Therapeutics Inc filed Critical Proteon Therapeutics Inc
Publication of MX2010006211A publication Critical patent/MX2010006211A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21036—Pancreatic elastase (3.4.21.36)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a métodos para la fabricación, purificación, formulación, y uso de proteínas elastasa recombinantes, bilógicamente activas. Se describen métodos recombinantes para producir proteínas elastasa terapéuticamente útiles, así como composiciones farmacéuticas que comprenden dichas proteínas elastasa. También se describen preparaciones de proteínas elastasa recombinantes novedosas y de proteína. Se describen métodos para tratar y prevenir enfermedades de los conductos biológicos utilizando las composiciones farmacéuticas que contienen las proteínas elastasa de la invención.
MX2010006211A 2007-12-04 2008-12-04 Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. MX2010006211A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99231907P 2007-12-04 2007-12-04
US12/327,809 US8501449B2 (en) 2007-12-04 2008-12-03 Recombinant elastase proteins and methods of manufacturing and use thereof
PCT/US2008/085559 WO2009079220A2 (en) 2007-12-04 2008-12-04 Recombinant elastase proteins and methods of manufacturing and use thereof

Publications (1)

Publication Number Publication Date
MX2010006211A true MX2010006211A (es) 2010-10-25

Family

ID=40344763

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013000540A MX341317B (es) 2007-12-04 2008-12-04 Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas.
MX2010006211A MX2010006211A (es) 2007-12-04 2008-12-04 Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2013000540A MX341317B (es) 2007-12-04 2008-12-04 Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas.

Country Status (25)

Country Link
US (14) US8501449B2 (es)
EP (3) EP2229440B9 (es)
JP (3) JP5829808B2 (es)
KR (3) KR20180011860A (es)
CN (4) CN101918547B (es)
AR (1) AR069584A1 (es)
AU (1) AU2008338743B2 (es)
BR (1) BRPI0819977A2 (es)
CA (1) CA2707051C (es)
CY (2) CY1114724T1 (es)
DK (2) DK2229440T3 (es)
ES (2) ES2436783T3 (es)
HR (2) HRP20131135T1 (es)
HU (1) HUE032739T2 (es)
IL (2) IL206157A (es)
LT (1) LT2666854T (es)
MX (2) MX341317B (es)
NZ (2) NZ585866A (es)
PL (2) PL2666854T3 (es)
PT (2) PT2229440E (es)
RS (2) RS53083B (es)
RU (1) RU2611200C2 (es)
SI (2) SI2229440T1 (es)
TW (2) TWI619726B (es)
WO (1) WO2009079220A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501449B2 (en) * 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
CN102250863B (zh) * 2011-04-29 2012-12-05 天津金斯坦生物科技有限公司 基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途
CA2905180C (en) * 2013-03-15 2023-03-07 Alder Biopharmaceuticals, Inc. Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
US10202630B2 (en) * 2013-03-15 2019-02-12 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
KR20250121449A (ko) * 2017-03-10 2025-08-12 볼트 쓰레즈, 인크. 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법
DK3638293T5 (da) * 2017-06-15 2024-08-26 Univ Chicago Sammensætninger til behandling af cancer
JP2023502259A (ja) * 2019-11-26 2023-01-23 チルドレンズ ホスピタル メディカル センター 肺疾患の治療のためのｃｅｌａ－１阻害
WO2021146233A1 (en) * 2020-01-14 2021-07-22 Basf Se Method for producing recombinant protein in yeast cells
CN116261592A (zh) * 2020-08-18 2023-06-13 昂希莱斯制药公司 经修饰的丝氨酸蛋白酶前蛋白
CN116157513A (zh) * 2020-08-18 2023-05-23 昂希莱斯制药公司 经修饰的猪胰腺弹性蛋白酶蛋白

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2508408A (en) 1943-10-11 1950-05-23 Sidney H Liebson Averaging indicator
US2546308A (en) 1948-12-29 1951-03-27 Kahler John Floor marking device
US5212068A (en) * 1985-04-05 1993-05-18 Sankyo Company Limited Human pancreatic elastase
JP2874751B2 (ja) 1986-04-09 1999-03-24 ジェンザイム・コーポレーション 希望する蛋白質をミルク中へ分泌する遺伝子移植動物
US5162205A (en) 1986-04-26 1992-11-10 Sankyo Company, Limited Human pancreatic elastase I
JPH0673456B2 (ja) * 1986-04-26 1994-09-21 三共株式会社 ヒト・膵臓エラスタ−ゼ▲ｉ▼
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5543302A (en) * 1988-05-27 1996-08-06 Solvay Enzymes, Inc. Proteases of altered stability to autolytic degradation
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
AU635844B2 (en) 1989-11-06 1993-04-01 Cell Genesys, Inc. Production of proteins using homologous recombination
GB8927722D0 (en) 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5503333A (en) * 1993-06-23 1996-04-02 Laventure; David Duster extension tube system with dust collecting region and tube cleaner and method of using the same
DE69528614T2 (de) * 1994-07-07 2003-06-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno, Delft Modifizierte Proenzyme als Substrate für proteolische Enzyme
US5955072A (en) * 1994-07-13 1999-09-21 Sankyo Company, Limited Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide
US7531325B2 (en) * 1997-04-25 2009-05-12 Sembiosys Genetics Inc. Method for cleavage of fusion proteins
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
GB9817909D0 (en) * 1998-08-17 1998-10-14 Zeneca Ltd DNA constructs
GB9908458D0 (en) 1999-04-13 1999-06-09 Queen Mary & Westfield College Enzyme
AU4970900A (en) 1999-05-05 2000-11-21 Genentech Inc. Elastase variants and substrates
US7001892B1 (en) * 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
US7063838B1 (en) * 1999-09-24 2006-06-20 Proteon Therapeutics Llc Methods for treating an artery or vein in a human subject
ES2534938T3 (es) * 1999-09-24 2015-04-30 Proteon Therapeutics, Inc. Una elastasa para abrir conductos biológicos obstruidos
US7351549B2 (en) * 2000-01-24 2008-04-01 Polymun Scientific Immunbiologische Forschung Gmbh Method for the manufacture of recombinant trypsin
JP2003523756A (ja) * 2000-02-24 2003-08-12 フィロス インク． 触媒蛋白質の生成のための改良された方法
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
EP1624786A4 (en) 2003-02-20 2011-07-13 Proteon Therapeutics Inc METHOD FOR THE TREATMENT AND PREVENTION OF ILLNESSES OF BIOLOGICAL CHANNELS
US7571008B2 (en) 2003-08-18 2009-08-04 Medtronic, Inc. System and apparatus for remote activation of implantable medical devices
US20070004658A1 (en) * 2004-06-21 2007-01-04 Nick Vandeghinste Method and means for treatment of osteoarthritis
BRPI0515569A (pt) 2004-09-22 2008-07-29 Proteon Therapeutics Inc métodos para reduzir vasospasmo em um segmento de um conduto biológico, para reduzir a capacidade de um vaso sofrer vasospasmo em um segmento de um conduto biológico e para reduzir o acúmulo de hiperplasia ìntima em um segmento de um conduto biológico
RU2299070C2 (ru) * 2005-02-08 2007-05-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения заболевания вен и способ ее получения
US20060193824A1 (en) * 2005-02-28 2006-08-31 Rubin Bruce K Methods for the treatment of infectious and inflammatory airway diseases
CN1769424A (zh) * 2005-09-20 2006-05-10 浙江大学 一种芽孢杆菌菌株及其用途
NZ596269A (en) * 2006-07-05 2012-12-21 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
US8501449B2 (en) * 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
WO2009124293A1 (en) * 2008-04-03 2009-10-08 Hudson Alpha Institute For Biotechnology Amplicon rescue multiplex polymerase chain reaction for amplificaton of multiple targets

Also Published As

Publication number Publication date
RU2010127232A (ru) 2012-01-10
KR20180011860A (ko) 2018-02-02
CA2707051C (en) 2019-05-21
IL206157A (en) 2013-07-31
EP3176262A1 (en) 2017-06-07
RS53083B (sr) 2014-06-30
IL226771A0 (en) 2013-07-31
EP2666854B1 (en) 2017-03-15
TW201643188A (zh) 2016-12-16
US20090162343A1 (en) 2009-06-25
PL2666854T3 (pl) 2017-08-31
US10301612B2 (en) 2019-05-28
KR101824350B1 (ko) 2018-01-31
JP2011505164A (ja) 2011-02-24
HK1148772A1 (en) 2011-09-16
US8501449B2 (en) 2013-08-06
PL2229440T3 (pl) 2014-07-31
CN104711243B (zh) 2019-06-11
US20180273928A1 (en) 2018-09-27
US20150322420A9 (en) 2015-11-12
BRPI0819977A2 (pt) 2020-08-18
RU2611200C2 (ru) 2017-02-21
CN103952388B (zh) 2017-10-03
US20130336956A1 (en) 2013-12-19
AR069584A1 (es) 2010-02-03
AU2008338743B2 (en) 2015-02-19
CN101918547B (zh) 2015-01-14
US20110008315A1 (en) 2011-01-13
PT2229440E (pt) 2013-11-11
NZ601592A (en) 2014-02-28
EP2229440A2 (en) 2010-09-22
CN101918547A (zh) 2010-12-15
US20180155703A1 (en) 2018-06-07
RS55982B1 (sr) 2017-09-29
MX341317B (es) 2016-08-15
SI2666854T1 (sl) 2017-06-30
HUE032739T2 (en) 2017-10-30
IL206157A0 (en) 2010-12-30
WO2009079220A3 (en) 2009-08-06
DK2666854T3 (da) 2017-05-22
AU2008338743A1 (en) 2009-06-25
WO2009079220A2 (en) 2009-06-25
SI2229440T1 (sl) 2013-12-31
HRP20170755T1 (hr) 2017-07-28
JP5829808B2 (ja) 2015-12-09
TWI619726B (zh) 2018-04-01
CN104711243A (zh) 2015-06-17
CN109893647A (zh) 2019-06-18
LT2666854T (lt) 2017-06-12
US10308924B2 (en) 2019-06-04
US20190010476A1 (en) 2019-01-10
JP2015172056A (ja) 2015-10-01
CY1118930T1 (el) 2018-01-10
JP6084653B2 (ja) 2017-02-22
ES2436783T3 (es) 2014-01-07
US20150166974A1 (en) 2015-06-18
HRP20131135T1 (hr) 2014-01-03
ES2627066T3 (es) 2017-07-26
US20200208132A1 (en) 2020-07-02
US20190062718A1 (en) 2019-02-28
CY1114724T1 (el) 2016-10-05
US20110081705A1 (en) 2011-04-07
CN103952388A (zh) 2014-07-30
PT2666854T (pt) 2017-06-28
US20150329846A1 (en) 2015-11-19
US20160243205A1 (en) 2016-08-25
EP2229440B1 (en) 2013-08-28
TWI577385B (zh) 2017-04-11
KR101732190B1 (ko) 2017-05-04
US9057060B2 (en) 2015-06-16
CA2707051A1 (en) 2009-06-25
EP2229440B9 (en) 2013-11-13
JP2017104114A (ja) 2017-06-15
US20160319267A1 (en) 2016-11-03
KR20160095184A (ko) 2016-08-10
KR20100120639A (ko) 2010-11-16
TW200938219A (en) 2009-09-16
DK2229440T3 (da) 2013-12-09
EP2666854A1 (en) 2013-11-27
NZ585866A (en) 2012-09-28
US20180208918A1 (en) 2018-07-26

Similar Documents

Publication Publication Date Title
MX341317B (es) Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas.
TNSN07238A1 (en) Method for producing sterile suspensions or lyophilisates of poorly soluble basic peptide complexes. pharmaceutical formulations containing the same, and use thereof as medicaments
MEP53308A (en) Novel peptides that bind to the erythropoietin receptor
WO2007038459A3 (en) Carboxyamine compounds and their use in the treatment of hdac dependent diseases
BRPI0418251B8 (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo
TW200637614A (en) Bendamustine pharmaceutical compositions
WO2004071426A3 (en) Compounds for the treatment of viral infection
BRPI0509369A (pt) azaindóis úteis como inibidores de jak e outras proteìna cinases
BRPI0412125A (pt) molécula de ácido nucleico isolada, polipeptìdeo de fusão, vetor de expressão, método de produzir um polipeptìdeo de fusão de vegf, captador de fator de crescimento de célula endotelial vascular, composição farmacêutica, método de tratar uma doença ou condição que são restabelecidas, melhoradas ou inibidas pela remoção ou inibição do fator de crescimento endotelial vascular, e, artigo de fabricação
MX2010002557A (es) Interferon alfa 2b modificado por glicol de polietileno, la preparacion y el uso del mismo.
UA104988C2 (uk) Похідні піроніндолу та спосіб їх отримання
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
EP1423414A4 (en) NEW DEPSIPEPTIDES AND METHOD FOR THE PRODUCTION THEREOF
CA2725873A1 (en) Monoclonal antibodies to basic fibroblast growth factor
ATE549353T1 (de) Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
NO20063193L (no) Fusjonerte pyrrolokarbazoler og fremgangsmater for fremstilling derav
PL1987063T3 (pl) Peptydy i pochodne peptydów, ich wytwarzanie oraz ich zastosowanie do wytwarzania terapeutycznie i/lub profilaktycznie czynnej kompozycji farmaceutycznej
MX2023009921A (es) Formulaciones de proteinas de fusion ace2-fc.
WO2007134118A3 (en) Protein based composition and methods of using same
WO2006078576A3 (en) Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
MXPA05010575A (es) Peptacuerpo para el tratamiento del cancer.
DK1969003T3 (da) Anvendelser af et neurotrofisk faktor-protein
UA94036C2 (ru) Фармацевтическая композиция бендамустина, предназначенная для лиофилизации
WO2006137938A3 (en) Antibody fragments for protection from pathogen infection and methods of use thereof
UY31131A1 (es) "oxazolidinonas sustituidas y su uso

Legal Events

Date Code Title Description
FG Grant or registration