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MX2010006107A - Derivados de espiroindolinona. - Google Patents

Derivados de espiroindolinona.

Info

Publication number
MX2010006107A
MX2010006107A MX2010006107A MX2010006107A MX2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A
Authority
MX
Mexico
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
compounds
esters
Prior art date
Application number
MX2010006107A
Other languages
English (en)
Inventor
Zhuming Zhang
Jing Zhang
Qingjie Ding
Nan Jiang
Song Yang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010006107A publication Critical patent/MX2010006107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan compuestos de la fórmula (I), (ver fórmula (1)) y sales farmacéuticamente aceptables y ésteres de los mismos, en donde W, V, X, Y, A, R y R´ son como se describe en la presente, procedimientos para elaborar los compuestos y métodos para usarlos, en particular como agentes anticáncer.
MX2010006107A 2007-12-14 2008-12-05 Derivados de espiroindolinona. MX2010006107A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1369107P 2007-12-14 2007-12-14
US10743108P 2008-10-22 2008-10-22
PCT/EP2008/066874 WO2009077357A1 (en) 2007-12-14 2008-12-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
MX2010006107A true MX2010006107A (es) 2010-06-25

Family

ID=40289301

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006107A MX2010006107A (es) 2007-12-14 2008-12-05 Derivados de espiroindolinona.

Country Status (12)

Country Link
US (1) US8134001B2 (es)
EP (1) EP2229396B1 (es)
JP (1) JP2011506380A (es)
KR (1) KR20100076037A (es)
CN (1) CN101896486A (es)
AT (1) ATE519764T1 (es)
AU (1) AU2008337651A1 (es)
BR (1) BRPI0821255A2 (es)
CA (1) CA2707456A1 (es)
IL (1) IL205354A0 (es)
MX (1) MX2010006107A (es)
WO (1) WO2009077357A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
AU2010319595B2 (en) * 2009-11-12 2015-09-17 The Regents Of The University Of Michigan Spiro-oxindole MDM2 antagonists
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
JP2014500870A (ja) 2010-11-12 2014-01-16 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン スピロ−オキシインドールｍｄｍ２アンタゴニスト
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CA2829188C (en) 2011-03-10 2016-10-18 Daiichi Sankyo Company, Limited Dispiropyrrolidine derivatives
ES2624808T3 (es) 2011-05-11 2017-07-17 The Regents Of The University Of Michigan Antagonistas de MDM2 espirooxindólicos
CN102321095B (zh) * 2011-05-26 2014-09-10 兰州大学 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用
EP2760845B1 (en) * 2011-09-27 2016-11-16 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
CN102627650B (zh) * 2012-03-08 2015-07-08 徐州师范大学 手性四氢吡咯-3,2′-氧化吲哚螺环化合物及其合成方法
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
EP3036222A2 (en) * 2013-08-23 2016-06-29 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
JP6503386B2 (ja) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
KR20170042779A (ko) 2014-08-21 2017-04-19 베링거 인겔하임 인터내셔날 게엠베하 Mdm2-p53 억제제로서의 신규 스피로[3h-인돌-3,2'-피롤리딘]-2(1h)-온 화합물 및 유도체
CA2976752C (en) 2015-02-20 2019-12-17 Daiichi Sankyo Company, Limited Method for treating cancer by combined use
TWI697329B (zh) 2015-04-13 2020-07-01 日商第一三共股份有限公司 血液癌症治療用之醫藥及其用途
PL3359542T3 (pl) 2015-10-09 2021-09-20 Boehringer Ingelheim International Gmbh Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
KR20190068544A (ko) 2016-10-17 2019-06-18 다이이찌 산쿄 가부시키가이샤 Mdm2 저해제와 dna 메틸트랜스페라아제 저해제의 병용 치료법
TW202100526A (zh) 2019-03-06 2021-01-01 日商第一三共股份有限公司 吡咯并吡唑衍生物
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN116253736B (zh) * 2023-01-06 2024-06-18 中山大学 一种吡唑β-内酰胺类衍生物及其制备方法和应用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495007B2 (en) * 2006-03-13 2009-02-24 Hoffmann-La Roche Inc. Spiroindolinone derivatives
EP1996591B1 (en) 2006-03-13 2011-01-12 F. Hoffmann-La Roche AG Spiroindolinone derivatives
US20070213341A1 (en) * 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives

Also Published As

Publication number Publication date
KR20100076037A (ko) 2010-07-05
US20090156610A1 (en) 2009-06-18
WO2009077357A1 (en) 2009-06-25
IL205354A0 (en) 2010-12-30
EP2229396B1 (en) 2011-08-10
JP2011506380A (ja) 2011-03-03
EP2229396A1 (en) 2010-09-22
ATE519764T1 (de) 2011-08-15
CA2707456A1 (en) 2009-06-25
US8134001B2 (en) 2012-03-13
AU2008337651A1 (en) 2009-06-25
CN101896486A (zh) 2010-11-24
BRPI0821255A2 (pt) 2015-06-16

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