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MX2010004759A - Piperidinas 4,4-disustituidas como inhibidoras de renina. - Google Patents

Piperidinas 4,4-disustituidas como inhibidoras de renina.

Info

Publication number
MX2010004759A
MX2010004759A MX2010004759A MX2010004759A MX2010004759A MX 2010004759 A MX2010004759 A MX 2010004759A MX 2010004759 A MX2010004759 A MX 2010004759A MX 2010004759 A MX2010004759 A MX 2010004759A MX 2010004759 A MX2010004759 A MX 2010004759A
Authority
MX
Mexico
Prior art keywords
disubstituted
disubstituted piperidines
salts
piperidines
piperidinesof
Prior art date
Application number
MX2010004759A
Other languages
English (en)
Inventor
Peter Herold
Robert Mah
Christiane Marti
Stefan Stutz
Stjepan Jelakovic
Vincenzo Tschinke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2010004759A publication Critical patent/MX2010004759A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La solicitud se refiere a piperidinas 4,4-disustituidas de la fórmula general (I) y sus sales, de preferencia sus sales farmacéuticamente aceptables, en donde R2 tiene los significados explicados en la descripción, a un proceso para su preparación, y al uso de estos compuestos como medicamentos, en especial como inhibidores de renina.
MX2010004759A 2007-11-02 2008-10-31 Piperidinas 4,4-disustituidas como inhibidoras de renina. MX2010004759A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07119884 2007-11-02
PCT/EP2008/064767 WO2009056617A2 (en) 2007-11-02 2008-10-31 4,4-disubstituted piperdines as renin inhibitors

Publications (1)

Publication Number Publication Date
MX2010004759A true MX2010004759A (es) 2010-05-19

Family

ID=39204939

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004759A MX2010004759A (es) 2007-11-02 2008-10-31 Piperidinas 4,4-disustituidas como inhibidoras de renina.

Country Status (13)

Country Link
US (1) US20100267713A1 (es)
EP (1) EP2215088A2 (es)
JP (1) JP2011503022A (es)
KR (1) KR20100075590A (es)
CN (1) CN101918398A (es)
AR (1) AR069145A1 (es)
AU (1) AU2008320806A1 (es)
BR (1) BRPI0819352A2 (es)
CA (1) CA2699889A1 (es)
EA (1) EA201000720A1 (es)
MX (1) MX2010004759A (es)
TW (1) TW200934499A (es)
WO (1) WO2009056617A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009078481A1 (ja) 2007-12-19 2009-06-25 Dainippon Sumitomo Pharma Co., Ltd. 二環性へテロ環誘導体
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123293A (en) * 1995-09-07 2003-06-24 Hoffmann La Roche Piperidine derivatives, their preparation and pharmaceutical compositions containing them
US6197959B1 (en) * 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
TW200716622A (en) * 2005-03-31 2007-05-01 Speedel Experimenta Ag Substituted piperidines
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines

Also Published As

Publication number Publication date
US20100267713A1 (en) 2010-10-21
EP2215088A2 (en) 2010-08-11
CA2699889A1 (en) 2009-05-07
EA201000720A1 (ru) 2010-10-29
JP2011503022A (ja) 2011-01-27
WO2009056617A2 (en) 2009-05-07
BRPI0819352A2 (pt) 2015-04-22
AR069145A1 (es) 2009-12-30
KR20100075590A (ko) 2010-07-02
AU2008320806A1 (en) 2009-05-07
CN101918398A (zh) 2010-12-15
TW200934499A (en) 2009-08-16
WO2009056617A3 (en) 2009-07-09

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal