MX2010004007A - Metodo para la produccion de un anticuerpo. - Google Patents
Metodo para la produccion de un anticuerpo.Info
- Publication number
- MX2010004007A MX2010004007A MX2010004007A MX2010004007A MX2010004007A MX 2010004007 A MX2010004007 A MX 2010004007A MX 2010004007 A MX2010004007 A MX 2010004007A MX 2010004007 A MX2010004007 A MX 2010004007A MX 2010004007 A MX2010004007 A MX 2010004007A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- fragment
- chain
- dna encoding
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 abstract 6
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención proporciona un método para producir un anticuerpo recombinante de manera eficiente y a bajo costo. Se describe un método para producir un anticuerpo o un fragmento del mismo, que comprende permitir a una célula producir el anticuerpo o el fragmento, en donde la célula contiene un mayor número de copias de un ADN exógeno que codifica la cadena ligera o un fragmento de la misma del anticuerpo que el número de copias contenidas en la célula de un ADN exógeno que codifica la cadena pesada o un fragmento de la misma del anticuerpo. La presente invención también proporciona un ventor recombinante que comprende una copia de un ADN que codifica la cadena pesada o un fragmento de la misma de un anticuerpo y dos o más copias de un ADN que codifica la cadena ligera o un fragmento de la misma del anticuerpo; y un transformante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007267384 | 2007-10-15 | ||
| JP2008103308 | 2008-04-11 | ||
| PCT/JP2008/068588 WO2009051108A1 (ja) | 2007-10-15 | 2008-10-14 | 抗体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010004007A true MX2010004007A (es) | 2010-06-15 |
Family
ID=40567372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010004007A MX2010004007A (es) | 2007-10-15 | 2008-10-14 | Metodo para la produccion de un anticuerpo. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9683027B2 (es) |
| EP (1) | EP2202307B2 (es) |
| JP (4) | JP4976502B2 (es) |
| KR (1) | KR101558009B1 (es) |
| CN (3) | CN103540632A (es) |
| AU (1) | AU2008312937B2 (es) |
| BR (1) | BRPI0818674B1 (es) |
| CA (1) | CA2701338C (es) |
| DK (1) | DK2202307T4 (es) |
| ES (1) | ES2499391T5 (es) |
| IL (2) | IL205051A (es) |
| MX (1) | MX2010004007A (es) |
| PL (1) | PL2202307T5 (es) |
| SG (1) | SG185302A1 (es) |
| SI (1) | SI2202307T2 (es) |
| TW (1) | TWI463010B (es) |
| WO (1) | WO2009051108A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2202307T4 (da) * | 2007-10-15 | 2021-10-04 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til fremstiling af et antistof |
| DK2493922T3 (en) | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
| NZ611862A (en) * | 2010-12-28 | 2015-05-29 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
| CA2903589A1 (en) * | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Cell culture media and methods of antibody production |
| CA2913687C (en) | 2013-07-04 | 2022-12-13 | F. Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
| WO2018002036A1 (en) | 2016-06-28 | 2018-01-04 | Zaklady Farmaceutyczne Polpharma Sa | Recombinant production of monoclonal antibodies |
| EP3541413A2 (en) | 2016-11-21 | 2019-09-25 | Polpharma Biologics S.A. | Aqueous pharmaceutical formulations |
| WO2025134341A1 (ja) * | 2023-12-22 | 2025-06-26 | 中外製薬株式会社 | 抗体の製造方法 |
| WO2025141786A1 (ja) * | 2023-12-27 | 2025-07-03 | 中外製薬株式会社 | 抗体の製造方法 |
| WO2025232879A1 (en) | 2024-05-10 | 2025-11-13 | Cytocares (Shanghai) Inc. | Anti-lilrb2 monospecific and bispecific antibody constructs and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| JPS6459878A (en) | 1987-08-31 | 1989-03-07 | Matsushita Electric Industrial Co Ltd | Semiconductor laser protective circuit |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992004363A1 (en) † | 1990-09-04 | 1992-03-19 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| AU668349B2 (en) | 1991-04-25 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| DE69333823T2 (de) | 1992-03-24 | 2006-05-04 | Cambridge Antibody Technology Ltd., Melbourn | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
| JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス，インク． | 異種抗体の生産 |
| CA2161351C (en) | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| EP0731842A1 (en) | 1993-12-03 | 1996-09-18 | Medical Research Council | Recombinant binding proteins and peptides |
| US5531053A (en) | 1994-06-14 | 1996-07-02 | Hamm; Hans | Spring fastener for holding insulation against an inner surface of cavity walling |
| WO1996002576A1 (en) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
| US5561053A (en) | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| JP2002514919A (ja) * | 1997-04-04 | 2002-05-21 | バイオサイト ダイアグノスティックス，インコーポレイテッド | 多価ライブラリーおよびポリクローナルライブラリー |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| ES2246069T3 (es) | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US20030003097A1 (en) † | 2001-04-02 | 2003-01-02 | Idec Pharmaceutical Corporation | Recombinant antibodies coexpressed with GnTIII |
| US6605176B2 (en) * | 2001-07-13 | 2003-08-12 | Taiwan Semiconductor Manufacturing Co., Ltd. | Aperture for linear control of vacuum chamber pressure |
| AU2002364956C1 (en) * | 2001-11-16 | 2009-05-28 | Biogen Idec Inc. | Polycistronic expression of antibodies |
| US20030157641A1 (en) † | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| JP5452835B2 (ja) | 2003-07-15 | 2014-03-26 | 中外製薬株式会社 | 形質転換細胞によるＩｇＭの産生とその定量方法 |
| CN1961071A (zh) * | 2004-03-15 | 2007-05-09 | 比奥根艾迪克Ma公司 | 使用可选剪接在真核细胞中表达多肽多聚体的方法和构建物 |
| PT1674111E (pt) * | 2004-07-09 | 2010-12-15 | Chugai Pharmaceutical Co Ltd | Anticorpo anti-glipicano 3 |
| GB0425534D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Process for obtaining antibodies |
| SG164383A1 (en) * | 2005-07-21 | 2010-09-29 | Abbott Lab | Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis |
| DK2202307T4 (da) * | 2007-10-15 | 2021-10-04 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til fremstiling af et antistof |
-
2008
- 2008-10-14 DK DK08838661.0T patent/DK2202307T4/da active
- 2008-10-14 SG SG2012076485A patent/SG185302A1/en unknown
- 2008-10-14 JP JP2009538093A patent/JP4976502B2/ja active Active
- 2008-10-14 ES ES08838661T patent/ES2499391T5/es active Active
- 2008-10-14 MX MX2010004007A patent/MX2010004007A/es active IP Right Grant
- 2008-10-14 AU AU2008312937A patent/AU2008312937B2/en active Active
- 2008-10-14 BR BRPI0818674-0A patent/BRPI0818674B1/pt active IP Right Grant
- 2008-10-14 WO PCT/JP2008/068588 patent/WO2009051108A1/ja not_active Ceased
- 2008-10-14 EP EP08838661.0A patent/EP2202307B2/en active Active
- 2008-10-14 US US12/734,094 patent/US9683027B2/en active Active
- 2008-10-14 KR KR1020107008087A patent/KR101558009B1/ko active Active
- 2008-10-14 CN CN201310401442.2A patent/CN103540632A/zh active Pending
- 2008-10-14 CA CA2701338A patent/CA2701338C/en active Active
- 2008-10-14 CN CN201610656433.1A patent/CN106244651A/zh active Pending
- 2008-10-14 PL PL08838661T patent/PL2202307T5/pl unknown
- 2008-10-14 CN CN200880106430A patent/CN101802192A/zh active Pending
- 2008-10-14 SI SI200831306T patent/SI2202307T2/sl unknown
- 2008-10-15 TW TW097139552A patent/TWI463010B/zh active
-
2010
- 2010-04-13 IL IL205051A patent/IL205051A/en active IP Right Grant
-
2012
- 2012-04-12 JP JP2012090908A patent/JP5788830B2/ja active Active
-
2015
- 2015-06-05 JP JP2015114464A patent/JP6092304B2/ja active Active
- 2015-07-23 IL IL240122A patent/IL240122B/en active IP Right Grant
-
2017
- 2017-02-08 JP JP2017020965A patent/JP6506786B2/ja active Active
- 2017-05-08 US US15/589,000 patent/US11136375B2/en active Active
-
2021
- 2021-04-16 US US17/233,008 patent/US12145978B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |