[go: up one dir, main page]

MX2010003886A - Metodo para producir nucleosidos. - Google Patents

Metodo para producir nucleosidos.

Info

Publication number
MX2010003886A
MX2010003886A MX2010003886A MX2010003886A MX2010003886A MX 2010003886 A MX2010003886 A MX 2010003886A MX 2010003886 A MX2010003886 A MX 2010003886A MX 2010003886 A MX2010003886 A MX 2010003886A MX 2010003886 A MX2010003886 A MX 2010003886A
Authority
MX
Mexico
Prior art keywords
derivative
compound
salts
catalyst
alkyl
Prior art date
Application number
MX2010003886A
Other languages
English (en)
Inventor
Norbert Kraut
Oliver Jungmann
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of MX2010003886A publication Critical patent/MX2010003886A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un m?todo para producir un compuesto de nucle?sido libre, excluyendo el compuesto 2'-desoxi-5-azacitidina (Decitabina), al hacer reaccionar un donador de gluc?sido, de preferencia un derivado de 1-hal?geno, o 1-O-arilo, 1-O-alquilo, o un imidato, de preferencia un derivado de triclorometilo, o un derivado de tioalquilo de un monosac?rido u oligosac?rido bloqueado, de preferencia derivados de ribosa y/o 2-desoxirribosa con una base de nucle?sido protegida, en un solvente anhidro adecuado y en presencia de un catalizador, y eliminar los grupos protectores de dicho compuesto de nucle?sido bloqueado, en donde dicho catalizador se selecciona del grupo que comprende sales de un ?cido sulf?nico alif?tico y/o sales de un ?cido inorg?nico fuerte que contiene un ani?n no nucle?filo.
MX2010003886A 2007-10-10 2008-10-10 Metodo para producir nucleosidos. MX2010003886A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07019825A EP2048151A1 (en) 2007-10-10 2007-10-10 Method for producing nucleosides by direct glycosylation of the nucleoside base
PCT/EP2008/063582 WO2009047314A2 (en) 2007-10-10 2008-10-10 Method of producing nucleosides

Publications (1)

Publication Number Publication Date
MX2010003886A true MX2010003886A (es) 2010-04-30

Family

ID=39485184

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003886A MX2010003886A (es) 2007-10-10 2008-10-10 Metodo para producir nucleosidos.

Country Status (13)

Country Link
US (1) US20100210833A1 (es)
EP (2) EP2048151A1 (es)
JP (1) JP5586468B2 (es)
KR (1) KR101551778B1 (es)
CN (1) CN102119166A (es)
AU (1) AU2008309553B2 (es)
BR (1) BRPI0818249B8 (es)
CA (1) CA2701856C (es)
EA (1) EA017134B1 (es)
ES (1) ES2513241T3 (es)
MX (1) MX2010003886A (es)
NZ (1) NZ584372A (es)
WO (1) WO2009047314A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
HUE055911T2 (hu) * 2008-05-15 2021-12-28 Celgene Corp Citidin-analógokat tartalmazó orális készítmények, és eljárások azok alkalmazására
EP2318423B1 (en) 2008-08-08 2014-05-07 ScinoPharm Taiwan, Ltd. Process for making 5-azacytosine nucleosides and their derivatives
JP2012504652A (ja) * 2008-10-03 2012-02-23 サイノファーム タイワン リミテッド デシタビンの合成
US8586729B2 (en) 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
IT1399195B1 (it) 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
CN102127135B (zh) * 2010-12-24 2013-12-11 中国科学院上海有机化学研究所 一种嘧啶类核苷化合物或嘌呤类核苷化合物的制备方法
AU2012236476A1 (en) 2011-03-31 2013-05-02 Celgene International Sarl Systhesis of 5-azacytidine
WO2013178571A1 (en) * 2012-05-29 2013-12-05 F. Hoffmann-La Roche Ag Process for the preparation of 2-deoxy-2-fluoro-2-methyl-d-ribofuranosyl nucleoside compounds
CN110028537A (zh) * 2018-01-11 2019-07-19 上海百灵医药科技有限公司 一种地西他滨的合成方法
CN108299518A (zh) * 2018-02-02 2018-07-20 王成宇 一种2`-脱氧-β-尿苷的合成方法
CN110128485B (zh) * 2018-02-09 2022-06-07 鲁南制药集团股份有限公司 一种阿扎胞苷的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
WO1995012593A1 (en) 1993-11-05 1995-05-11 The Noguchi Institute 5-0-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, process for producing the same, and use thereof
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
JP2001524936A (ja) * 1996-10-16 2001-12-04 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド プリンｌ―ヌクレオシド類およびその用途
ATE282034T1 (de) * 1998-08-12 2004-11-15 Gilead Sciences Inc Verfahren zur herstellung von 1,3- oxathiolannukleoside
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)

Also Published As

Publication number Publication date
AU2008309553B2 (en) 2013-01-17
WO2009047314A2 (en) 2009-04-16
KR101551778B1 (ko) 2015-09-09
JP5586468B2 (ja) 2014-09-10
CA2701856C (en) 2016-05-03
WO2009047314A3 (en) 2012-03-01
NZ584372A (en) 2011-11-25
US20100210833A1 (en) 2010-08-19
EP2197892B1 (en) 2014-07-16
KR20100099104A (ko) 2010-09-10
EP2197892A2 (en) 2010-06-23
BRPI0818249A2 (pt) 2015-04-07
BRPI0818249B8 (pt) 2021-05-25
AU2008309553A1 (en) 2009-04-16
EP2048151A1 (en) 2009-04-15
CA2701856A1 (en) 2009-04-16
BRPI0818249B1 (pt) 2021-04-20
ES2513241T3 (es) 2014-10-24
JP2011526580A (ja) 2011-10-13
EA017134B1 (ru) 2012-10-30
EA201070438A1 (ru) 2011-02-28
CN102119166A (zh) 2011-07-06

Similar Documents

Publication Publication Date Title
MX2010003886A (es) Metodo para producir nucleosidos.
NL300963I9 (nl) Een verbinding omvattende een gemodificeerd oligonucleotide met een nucleobasensequentie bestaande uit 20 gekoppelde nucleosiden volgens EP-B1-2563920 conclusie 1 (SEQ ID NO: 80), waarbij de gemodificeerde oligonucleotide omvat: een tussenruimtesegment dat bestaat uit tien gekoppelde deoxynucleosiden; een 5' vleugelsegment dat bestaat uit vijf gekoppelde nucleosiden; en een 3' vleugelsegment dat bestaat uit vijf gekoppelde nucleosiden; waarbij het tussenruimtesegment is gepositioneerd tussen het 5' vleugelsegment en het 3' vleugelsegment, waarbij elke nucleoside van elk vleugelsegment een 2'-O-methoxyethylsuiker omvat; waarbij elke cytosine van het gemodificeerde oligonucleotide een 5-methylcytosine is, en waarbij elke internucleosidekoppeling van het gemodificeerde oligonucleotide een fosforothioaatkoppeling is; en in het bijzonder inotersen; en derivaten daarvan, zoals zouten ervan, waaronder natriumzouten, zoals beschermd door EP-B1-2563920.
ES2620131T3 (es) Nucleótidos marcados
AR082066A2 (es) Metodo y uso de analogos de nucleosidos fluorados modificados
ES2655916T3 (es) Aminoglucósidos y usos de los mismos para tratar trastornos genéticos
CA2510477A1 (en) Process for the preparation of oligonucleotides
WO2007014894A3 (en) Glucopyranosyl-substituted ( (hetero) cycloalyklethynyl-benzyl) -benzene derivatives and use thereof as sodium-dependent glucose cotransporter (sglt) inhibitors
WO2007121918A3 (en) Use of 2-(purin-9-yl)-tetrahydofuran-3,4-diol derivatives as adenosine a2a receptor agonists
WO2006015357A3 (en) 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
Huchting et al. Synthesis of T‐705‐Ribonucleoside and T‐705‐Ribonucleotide and Studies of Chemical Stability
WO2003068795A1 (en) Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof
CA2671306A1 (en) Process for preparation of 4'-azido cytidine derivatives
WO2007121921A3 (en) Purine derivatives for use as adenosin a2a receptor agonists
EP0587364A1 (en) A process for anomerizing nucleosides
NZ593882A (en) Process for the synthesis of l-fucosyl di- or oligosaccharides and novel 2,3,4 tribenzyl-fucosyl derivatives intermediates thereof
IE883406L (en) 2',3'-Dideoxy-2'-fluoronucleosides
AU2008309552A1 (en) Method of producing 2' -deoxy-5-azacytidine (Decitabine)
BRPI0606324A2 (pt) derivados de purina agindo como agonistas de receptor de a2a
IE33786L (en) Pyrimidine nucleosides
Hysell et al. Synthesis and stability of exocyclic triazine nucleosides
Sujino et al. Stereocontrolled Synthesis of. BETA.-D-2'-Deoxyribonucleosides by Intramolecular Glycosylation.
CA2577449C (en) Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
IL277066B2 (en) History of lna-dicarboxylic acid and process for their preparation
DK1071692T3 (da) Fremgangsmåde til syntese af laminaribiose
AU2003238696A1 (en) Alkynylpurine compounds and production methods thereof

Legal Events

Date Code Title Description
FG Grant or registration